I wish I’d read that last line on my first read-through.
Dianabol
Pharmaceutical Name: Methandrostenolone / methandienone
Chemical Names: 17a-methyl-17b-hydroxy-1, 4-androstadien-3-one 1-Dehydro-17a-methyltestosterone methandienone
Molecular Weight: 300.44
Formula: C20H28O2
Melting Point: 159-164 degrees Celsius
Active Life: 3-8hours
Detection Time: up to 6 weeks
Anabolic/Androgenic Ratio (Range): 90-210:40-60
Methandrostenolone has long been a favorite of strength athletes and bodybuilders since it’s creation in 1956, with the explicit purpose of it’s creation being for the use by athletes. It was the compound’s ability to promote drastic protein synthesis, stimulate strength in a direct and fast-acting way, and it’s ability to enhance glycogenolysis that made it so popular, and why it’s popularity remains high today.
In terms of it’s medical use, methandrostenolone was/is used in the treatment of conditions such as interstitial-pituitary insufficiency, chronic adrenocortical insufficiency, thyrotoxicosis, diabetic angiopathies (retinopathy and nephropathy), steroidal diabetes, and pituitary dwarfism among others (1). However, due to the U.S. Food and Drug Administration’s belief that the compound was being used inside of the bodybuilding community far more than in the treatment of medical conditions, it ordered that American companies discontinue it’s manufacture in the early 1990’s. Numerous drug companies outside of U.S. borders continue to make the drug however, and it’s prevalence on the black market has remained very high.
Use/Dosing of Dianabol
The best use for methandrostenolone is short-term with most users preferring to use the product for between four to six weeks, although some will prolong the use with limited consequences to health, despite its strong hepatoxic effects. Many recreational users begin administering methandrostenolone at the start of a longer bulking stack to “jumpstart” gains in mass and strength. However, it is also commonly used prior to various sorts of competitions to realize it’s effects during that period.
Due to the active life, which is three to eight hours, multiple doses throughout the day of methandrostenolone should be utilized. It is best to maintain blood levels as evenly as possible, therefore dividing doses throughout the day. Some argue that administration of the drug should cease a few hours before you sleep as it will cause further HPTA shut down, as the body’s natural testosterone production during sleep could be affected. However, if you are taking other compounds along with methandrostenolone, these will already be shutting down your natural testosterone production, so this is not a concern.
In terms of dosing, 10 mg can increase androgen activity by five times, as well as have an effect of a 50 to 70% decrease in cortisol activity (2). Despite this, the majority of anecdotal evidence suggests that twenty to forty milligrams is the norm for first time users (as ascertained from the anecdotal knowledge gleamed from various users). However, doses ranging from 100-150mg and higher have been reported by some experienced users. As with the majority of anabolic drugs, the returns are seemingly diminished and the likelihood of side effects increase as the doses do.
Most users who have run methandrostenolone only cycles say that it is difficult to maintain gains post cycle. Others say that the water retention experienced while on methandrostenolone will be shed but the gains in strength and mass can be maintained if other compounds are stacked with it. Others stated that the gains experienced while on methandrostenolone are short lived no matter what the circumstances and the compound should only be used as a quick fix for either competition or else simply as a motivator while waiting to notice the effects of long estered compounds. Personal experimentation is once again the only way to see how an individual reacts.
Risks/Side Effects of using Dianabol Estrogenic side effects can be a concern with methandrostenolone, as it converts to estradiol via aromatase, although this is quite modest at best. High blood pressure, water retention, gynocomastia, and acne are all possible undesirable side effects during use of methandrostenolone. As an aside, a high number of users have also reported experiencing nose bleeds while using the compound. Some attribute this to an increase in blood pressure, while others have not noticed a rise in their blood pressure but still experience an increase in the number of nose bleeds they have while using methandrostenolone. Use of an aromatase inhibitor such as Arimidex or estrogen blocker such as Nolvadex should help to counteract some of these side effects. As for potential hair loss, the androgenic metabolite 5-alpha dihydromethandrostenolone is only produced in trace amounts, and therefore hairloss should not be a concern(3). In women it is not uncommon for virilizing side effects to occur, including increased growth of androgen-sensitive hair and deepening the voice, amongst others. Like most oral steroids methandrostenolone is 17-alpha-alkylated so that it can’t be broken down into a 17-ketosteroid which leaves the substance ineffective. However, this causes liver values to become elevated over a short period of time. It is for this reason that long-term use of any 17-alpha-alkylated steroid is considered dangerous. Despite this however, no long-term damage should be expected if use is kept to relatively short periods, with liver values returning to previous levels after use is discontinued in nearly all cases (4). It should also be noted that methandrostenolone may be less useful to those competing in aerobic events as it also diminishes cell respiration(5). This may inhibit an individual’s ability to perform at their maximum capacity. References 1. Metkinen Online Drug Profile, via internet, located at http://www.metkinen.fi/products/ferm...androstenolone 2. Rea, Author L., 2002, Chemical Muscle Enhancement: Bodybuilder�s Desk Reference 3. Llewellyn, William, Anabolics 2004, 2003-4, Molecular Nutrition, pp. 93-6 4. Harrison LM, Fennessey PV., Methandrostenolone metabolism in humans: potential problems associated with isolation and identification of metabolites, Steroid Biochem 1990 Aug 14;36(5):407-14 5. Blasberg ME, Langan CJ, Clark AS., The effects of 17 alpha-methyltestosterone, methandrostenolone, and nandrolone decanoate on the rat estrous cycle, Physiol Behav 1997 Feb;61(2) 6. Serakovskii S, Mats’koviak I., Effect of methanedienone (methandrostenolone) on energy processes and carbohydrate metabolism in rat liver cells, Farmakol Toksikol 1981 Mar-Apr;44(2):213-7
Winstrol Stanozolol
Pharmaceutical Name: Stanozolol
Chemical structure: 17 alpha-methyl-5alpha- androstano [3,2-c]pyrazol-17 beta-ol
Molecular Formula: C22H36N2O
Molecular weight of base: 344.5392
Active Life: 8 hours for most orals, 48 hours for injectable
Anabolic/Androgenic Ratio: 320/30
One of the most popular and widely recognized anabolic steroids, Winstrol enjoys a high popularity among steroid users. However, it may actually be one of the more over-used compounds as it’s abilities and effects will only be fully realized by a minority of users who are administering it for a specific purpose.
Stanozolol is a derivative of dihydrotestosterone. Despite this most users find that its activity is quite mild compared to other compounds with similar chemical origins. Individuals that are looking for mass gains will likely be disappointed. It is widely considered a cutting compound. Due to the lack of water retention most users find that they can acheive a dry look as long as their body fat is relatively low. The anabolic effects that are achieved are a result of its ability to increase protein synthesizing and nitrogen retention (2,4). However these effects are mild at best.
Many users report that their joints and ligaments have a dry feeling when using Winstrol, complaining often of ligament pain when lifting heavy. This would seemingly make the drug a poor choice for athletes other than bodybuilders who are trying to acheive a specific “look”, but there is some scientific evidence that suggests that stanozolol could in fact strengthen tendons and ligaments. However, with the vast majority of users reporting ligament and joint pain while on the compound it is difficult to recommend the drug if peak performance is desired for athletic competition.
Winstrol has a dramatic effect on levels of sex hormone-binding globulin in the body. This is because plasma binding proteins, like sex hormone-binding globulin, act to temporarily prevent steroid hormones from exerting their intended activities. By limiting this, it results in a greater percentage of free steroid hormone circulating in the body. This may actually result in a mechanism whereby stanozolol could help to increase the potency of a concurrently used steroid (5).
Use and Dosing of Winstrol
Winstrol is available as both an oral steroid as well as an injectable. While there are no differences in the compound itself, there are several advantages and disadvantages to using each compound. First, in an animal study, it was demonstrated that the injectable version was far superior to the oral version for nitrogen retention (2). Thus, the injectable version is better for preserving or building lean-body mass.
Another advantage of injecting stanozolol is that it will negate the first pass of the compound through the liver and therefore is less toxic to the organ. Despite these advantages however, there are a few disadvantages of choosing to inject, namely the comfort of the user. Stanozolol is notorious for causing pain at the injection site upon administration and for several days afterwards. This often causes users to begin administering the compound orally, especially because the injectable version can be taken orally as well.
With the active life of stanozolol being only eight hours, multiple doses of the oral compound throughout the day are recommended. As for injections, once a day is optimal to maintain stable blood levels of the compound, but every other day should be adequate due to it’s active life.
Male users often find that doses in the range of 25-100mgs per day are adequate to see results. Most first time users administer 50mgs per day and are happy with the effects.
Stanozolol is a drug that is fairly popular with women as well. This is primarily due to its anabolic nature, with the likelihood of androgenic side effects being rather small. First time female users report that doses ranging from 5-15mgs per day will result in quite dramatic gains. However like most compounds, users have experimented with doses far higher with the risks of the associated side effects becoming more pronounced as the dosages increase.
Due to the toxicity issues users often limit their cycles to six weeks or less. However other users have exceed this limit while running high doses and have reported little to no complications. If an individual does decide to run stanozolol for an extended period of time he or she should monitor their liver values via blood tests to ensure that no permanent damage occurs.
Side Effects and Risks of using Stanozolol
The oral form of stanozolol is a 17-alpha-alkylated substrate and liver toxicity is a concern. Elevated liver values will occur while running this drug. Even with the injectable version, liver damage can occur so precautions need to be taken.
Stanozolol is also very harsh on cholesterol levels often lowering HDL and raising LDL at the same time, even at extremely small doses. Users with histories of health problems should be wary of using this compound.
Androgen related side effects such as acne, prostate enlargement and an aggravation of male pattern baldness are often reported by users. Many users report that stanozolol is one of the harshest drugs in terms of hair loss.
As mentioned previously estrogenic side effects are not a factor with this compound as it does not aromatize. Virilizing side effects in women are much less likely to occur than with most other anabolic compounds, but there is still a risk that these may develop, especially with larger doses. As always these include deepening of the voice, body/facial hair growth, and enlargement of the clitoris, among others.
References
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Ellis AJ, Cawston TE, Mackie EJ., The differential effects of stanozolol on human skin and synovial fibroblasts in vitro: DNA synthesis and receptor binding., Agents Actions 1994 Mar;41(1-2):37-43
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Olson ME, Morck DW, Quinn KB. The effect of stanozolol on 15nitrogen retention in the dog. Can J Vet Res. 2000 Oct;64(4):246-8
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Minuto F, Barreca A, Melioli G. Indirect evidence of hormone abuse. Proof of doping? J Endocrinol Invest. 2003 Sep;26(9):919-23.
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Brestel EP, Thrush LB., The treatment of glucocorticosteroid-dependent chronic urticaria with stanozolol., J Allergy Clin Immunol 1988 Aug;82(2):265-9
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Llewellyn, William, Anabolics 2004, 2003-4, Molecular Nutrition, pp. 173-5
OP got his information from some bro on reddit.
@Dbkworldwide420 Read more and quit being afraid of needles. Also, start eating more food; you’re a prison sentence away from being someone’s girlfriend.
