[quote]Lift4Life wrote:
It’s amazing, no one is giving me an answer to my question.
So you know what? seeing as though a few of you are trying to attack the tone of my question (somehow that can be done on the internet haha), I come to the conclusion that none of you know the damn answer.
What’s true from all of these posts is that, Barr or anyone else here does not know (or is just simply not typing it in the forum) indefinately that “MUSCLE MILK” is harmful.
-I accept “ENDOCREATINE” is an unhealthy substance to ingest. However, I do not believe “MUSCLE MILK” carries the same effects, due to the quantities of Folic Acid, B6, B12 that are blended in the mix.
-What’s amazing is that he got you to stop using “MUSCLE MILK” and you’re simply taking his word without doing any investigating of your own.[/quote]
Quote from: Glycocyamine and Health
By David Tolson
"In addition, GAA carries an added risk when compared to creatine. The conversion of GAA to creatine via GAMT requires the presence of S-adenosylmethionine (SAMe), which is the methyl donor in virtually all known biological methylation reactions. The amount of SAMe normally used for endogenous creatine biosynthesis is greater than the amount used for all other methylation reactions combined. When this reaction takes place, homocysteine is produced as one of the end products. Increased blood concentrations of homocysteine have been associated with an increased risk for developing vascular disease. Rats on a GAA supplemented diet have blood homocysteine concentrations 49% higher than control levels. On the other hand, creatine supplementation was associated with a 27% decrease in homocysteine. This is because creatine supplementation downregulates GAA biosynthesis, thus decreasing methylation demand. Although there may be ways of reducing this negative effect (such as inclusion of betaine), it seems much more practical to just supplement with creatine. [3]
If glycocyamine does get past the liver intact, the effects will probably not be desirable. The fact that it competitively inhibits creatine transport is not the only reason. Glycocyamine is also transported across the blood brain barrier (BBB). This may be associated with a variety of negative effects, and the most well-known property of GAA in the brain is as a convulsant [1, 5-7]. GAA increases the production of reactive oxygen species (ROS) in the brain [1]. Other mechanisms of neurotoxicity include inhibition of Na+,K±ATPase, decreased membrane fluidity, and interaction with the GABA-A receptor [8-9]. It is unknown whether these effects are relevant at doses used for supplementation, but it seems unlikely. They primarily become a problem in GAMT deficiency, which results in both elevated brain GAA and creatine deficiency. Still, those with a history of epilepsy should definitely stay away from glycocyamine."
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Int J Dev Neurosci. 2003 Jun;21(4):183-9. Inhibition of Na+, K±ATPase activity in rat striatum by guanidinoacetate. Zugno AI, Stefanello FM, Streck EL, Calcagnotto T, Wannmacher CM, Wajner M, Wyse AT.
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Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E1095-100. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT.