[quote]Monster Tech wrote:
SWR-1240 wrote:
Monster Tech wrote:
your right, although it does say to much is bad and can hurt you
Would you mind quoting where it says that in the article?
Do you have something against Creatine?
Dangerous Creatine?
No, this isn’t the tagline for a new type of creatine, it means that creatine-like product on the market may actually be harmful to your health
There’s a little piece for you.
Try reading the article.
I do not have anything against creatine I use it on a daily bases
[/quote]
Try reading more than just the title of the article and one paragraph.
The “creatine-like product” is what may be harmful.
That’s a whole lot different than stating “too much is bad and can hurt you” referring to creatine in general.
More from the article you might want to read:
"While I am not-for-one-second suggesting that creatine is hard on our body (in fact, a recent study supports the lack of toxicity?Kreider, 2003), why throw in excess if it?s not going to have any benefit?
I will, however, state for the record that perpetually hammering our bodies with excess creatine may have one unfortunate side effect: creatine transporter downregulation. Creatine transporters are the proteins that allow creatine to enter into muscle. They bind creatine on the outside of the muscle cell and carry it across the cell membrane to the intracellular space.
Now we?ve all heard that these creatine transporter proteins would decrease in number with our creatine use (Guerrero-Ontiveros and Wallimann, 1998). In essence, this could occur because our body detects that we already have too much creatine in our muscle and it wants to minimize further transport?almost the same way our bodies drop our natural T levels while using steroids. This would result in less creatine in the muscles and subsequently less cell hydration, as well as a reduction in performance enhancement.
Well, it?s time for some GOOD NEWS: a recently published study showed that there was no change in the number of creatine transporters when people used typical creatine dosages for up to 2 months (Tarnopolsky et al., 2003). The earlier study showing the transporter downregulation (Guerrero-Ontiveros and Wallimann, 1998) used rats consuming roughly 1g/kg/day, and using our 100kg athlete, that would mean consuming 100g of creatine a day!
So this means that as long as we don?t go through a kilo of creatine a week then we?re home free, right? Well, maybe not. As great as this is for us, we have to be aware of the limitations of the research. The study in question only examined a maximum of 10g/day, 6 days a week, for 2 months. This means that several months after loading, we may still be susceptible to transporter downregulation?we just don?t know.
Logically speaking however, the less excess we have, the better the chance of staving off any reduction in transporters and keeping the benefits of creatine supplementation."
And:
" Dangerous Creatine?
No, this isn?t the tagline for a new type of creatine, it means that there?s a semi-popular creatine-like product on the market that may actually be harmful to your health. What?s worse is that there are now several copycat products on the market as well! As if that wasn?t bad enough, one of the potentially dangerous compounds (oh yes, there?s more than one!) that this product contains is ergolytic; i.e. something that decreases athletic performance.
This potentially dangerous ergolytic chemical is Guanidinopropionic Acid (GPA), which binds the creatine transporter and plugs it up so creatine can?t be transported into various tissues (similar to the concept of tamoxifen blocking the estrogen receptor, not allowing estrogen to bind). This is a problem, because most of our tissues can?t make creatine so it has to be transported in, and blocked transporters means a reduction in cellular creatine levels.
Bear in mind that creatine isn?t just a supplement, it?s a naturally occurring substance in our bodies that we need to survive! You know the impact of having 20% more creatine, now imagine having 80% less creatine! GPA induced creatine depletion can not only reduce muscle strength after a mere seven days of consumption (Gagnon et al., 2002), but has also been shown to convert fast-twitch muscle to slow-twitch (Ren et al., 1995)! So this substance might make you weaker and slower!
While these consequences should be enough to make you avoid supplements containing this chemical, there?s also a potentially dangerous side to consider: both our hearts and our brains have creatine transporters!!! Any time you start to mess around with our two most vital organs, it can?t be good. Fortunately, the brain seems to temporarily compensate for decreases in energy supply caused by GPA (O’Gorman et al., 1996), but do we really want our bodies to have to adapt to reduced energy levels? Of course not!
We also don?t want our hearts to be affected by GPA supplementation, but they are! In fact, 3 different studies showed that creatine levels in the heart dropped by 80-87% with GPA consumption in rats (Boehm et al., 2003, Neubauer et al., 1999; Horn et al., 2001). Now you can see why it?s nearly impossible to perform human studies using this substance! Clearly, you have to wonder what the manufacturers were thinking when they approved production of this supplement.
“But wait, there?s MORE! Order now and you?ll get another potentially dangerous ingredient for free!” One particular supplement (“SWOLE”) combines GPA with another potentially dangerous substance known as Glycocyamine (G-amine). Sadly, G-amine (also known as guanidinoacetate) has been picked up by a few different supplement companies who obviously don?t do any research on what they?re getting people to ingest.
The reason G-amine is so popular (from a marketing standpoint, not from the consumers?) is because it is the precursor to creatine. Just like Testosterone can come from andro, creatine comes from G-amine. The theory is that you jack up G-amine levels and you get a whole bunch more creatine. The really asinine part is that, you can just directly take creatine!
We can?t take Testosterone due to legal reasons, so we have to find other ways to increase its levels?enter prohormones (among other effective things). But for our purposes, there?s no reason to worry about creatine precursors because we can just take the substance directly. The whole precursor concept is really hot when it comes to marketing to laymen, which is where this supplement takes off.
Unfortunately, consuming this chemical seems to have the undesirable effect of elevating blood levels of a substance called homocysteine, which is a very strong risk factor for cardiovascular disease (Stead et al., 2001). Cardiovascular disease is easily the number one killer in the Western World, and the last thing we need to do is increase our risk for it. Conversely, taking creatine decreases homocysteine levels, raising even more therapeutic possibilities for this supplement. As if to spit on your grave, if you?re supplementing with creatine, G-amine may also decrease its uptake by muscles (Zugno et al., 2003)."