Hah, I don’t mean to put you on the spot. I’ve just seen that you know your stuff on a number of topics and figured in a lot of instances that it’s safe to default to you.
Great stuff. Thanks to everyone for sharing all this.
[quote]siouxperman wrote:
[quote]chimera182 wrote:
[quote]siouxperman wrote:
I’m sort of surprised no one has mentioned GLUT4 yet. My understanding is that the increased insulin sensitivity during exercise is directly related to GLUT4 activity. I believe it is this, rather than the increased circulation that was mentioned before, that is the cause of the decreased need for insulin, which is of course in response to the high concentration of catecholamines.
Given the relative flood of GLUT4 to the cell membrane that happens during exercise, it seems that, as BBB said before, it would be most beneficial to keep insulin high before and during your workout as local vasodilation combined with high GLUT4 activity should create an environment significantly more receptive to cellular diffusion as long as insulin is present. And as far as the anaconda protocol is concerned, doesn’t it rely more on leucine mediaed insulin release than carb mediated? [/quote]
I’ve never heard of it before. Where’d you come across it?[/quote]
Originally, I got a cursory overview of it in an exercise biochemistry class. It was an interesting topic, and the professor for the class was/is my research mentor and did his PhD work in muscular metabolism. He didn’t know great detail about the mechanism, but it was interesting enough that I read up about it and found that it is a pretty important regulator in glucose disposal during exercise. As far as I understand it, muscular contraction can translocate GLUT4 from the vesicles to the plasma membrane of the cell, providing an abundance of it to react in conjunction with insulin (through a number of reactions) for facilitated glucose transport during exercise. I’ve read about it playing a role in non insulin mediated glucose transport, but haven’t seen that claim substantiated. My knowledge of it is still pretty basic, so maybe someone like BBB could shed a little more light on the subject.[/quote]
Is this the same pathway as the Ras-Independent pathway of insulin action?
As far as I know it’s not the same pathway. I don’t know too much about the Ras pathways, but I think they are more involved in restoring glycogen stores within the muscle after exercise. That’s something I’d have to read more about though.
Does anyone know Berardi’s take on the topic? He has always advocated for PWO carbs and I would like to hear what he thinks about the new trend of carbs Pre-WO instead. He always seems to know his stuff.
Does anyone have any real info about Protein & Fat pwo? I couldn’t find anything w/ the search. I don’t know how it effects anabolism but I seem to feel better w/ a high fat & protein shake pwo than a High carb & protein shake.