I do have to say, ever since I dropped my dose significantly it’s gotten a lot easier to get done somehow. Maybe it’s related to the whole e2/serotonin thing? Maybe it’s not? I have no idea. But it certainly surprised me.
I’ve also been taking P5P and my Prolactin is the lowest it’s ever tested, so it could be that too. Too many changes at once to be sure unfortunately.
That’s the frustrating part. It would seem like replacing endogenous T with exogenous T would be a simple thing. But, damn, I had a hard time dialing it in to where I get the full benefits of TRT while minimizing sides.
The paper I referenced below stated: " First, E2 increases production of tryptophan hydroxylase[18,19] (TPH, the rate-limiting step in synthesis of serotonin from tryptophan), increasing the concentrations of serotonin in the body [20,21]. Second, E2 inhibits the expression of the gene for the serotonin reuptake transporter (SERT) and acts as an antagonist at the SERT, thus promoting the actions of serotonin by increasing the time that it remains available in synapses and interstitial spaces."
While this paper isn’t TRT specific, it does seem to help explain exactly what you stated.
“Estrogen receptors and serotonin receptors coexist in cells in a wide variety of tissues, and this critical review of the literature suggests that many of E2’s effects may be mediated by changes in the actions of serotonin (5HT). Serotonin is usually considered to be a neurotransmitter, but surprisingly, only 1% of serotonin in the human body is found in the CNS.”
No clue.
But on trt doses, it was high. So naturally it’s very high on 400mg.
All i know is i did my lowly 36mg shot of test this morning. I’ll do my other on thursday for a total of about 72mg per week
I shoot 34mg EOD for around 120mg/week, plus 250ug anastrazole each injection. I’ve messed around with lower doses, higher doses, no AI, every day, 2X/week, yada yada and have settled on my current protocol.
I’ll run this low dose thing for awhile. Should it fail, i may try KSmans old protocol. He was damn knowledgeable and recommended 1mg arimidex per 100mg test.
He was shamed off this site unfortunately by the no-ai group.
It also had a lot to do with him being an absolute quack who believed every human walking the earth had the exact same body chemistry and also everyone had an undiagnosed thyroid issue that only he was able to see.
Typical engineer
Kinda like the NO-Ai crowd?
Meh. If you need one then take one. Seems pretty simple. The only real argument as far as I’m concerned is how we define need. That should be pretty individual (outside of the obvious cases) and I don’t see the value in fighting about that sort of thing. On balance, taking an AI the rest of your life isn’t as healthy as not taking one. But if someone needs it and the need is demonstrated by trial and error then they shouldn’t be scolding for using it.
Horrible advice he gave. This caused MANY guys to never dial in. Crashing their e2. I was here during his time 3 years ago under a different username.
Oh i’m not saying it’s that amount isn’t a lot. But for some, it may be what is needed.
The biggest take away from all things this site has to offer is that everyone is unique and there are outliers.
Some can’t just lower dose and get E2 where it should be. They need to lower further without lowering T.
Anyway, we should probably stop now while we have a good thread going.
GO BILLS!!!
Well now you’ve just run this completely off the rails.
I’m from that area so you can imagine how pumped I am for this team this year.
I lived through those 4 Super Bowl losses and all in between.
I will say that it isn’t. It would seem like treating symptoms instead of the problem. I am not in the “No AI” crowd, and have certainly been in enough flaming disputes with some that are to make that clear. Here is my take. If you have issues with serotonin and being balanced with catecholamines, deal with that. Treat the condition. Screwing around with an ever changing dose of AI to fix a problem that technically isn’t the E2 anyway is a recipe for misery, and 1mg per 100mg is a recipe for misery. Do some guys need it? Yes, that is not really arguable with what is currently known. Do a lot of guys take it and not really need it? Absolutely. Do guys take it when they really need something else? I’m sure that they do. If a brain tumour gives you a headache, taking NSAIDS doesn’t really fix the problem but it might relieve symptoms. If your NFL team chokes without provocation, giving everybody a new bigger contract won’t solve that either. Just sayin’… I grew up 45 mins from Buffalo and laughed at my buddies dad suffering through 4 chokes. Ouch.
Here we goooooo
Negative.
SSRIs are what likely what caused me to need TRT in the first place. After being on them for 2+ years and then getting off, my libido and sex drive was never the same…
I think one day, years down the road, someone will do a meta study showing the rise of men getting on trt and find a (probably vague but persistent) causal link to SSRI use.
Won’t even need a study, my regular doc mentioned he scribes both men and women low dose TRT to offset the sexual side effects of SSRI’s that can’t be treated with something else. Said a few other MD’s are doing the same. Not sure how much success he has, when I asked him what those dosages were for men, they were crazy low… like 50mg a month.