Very Interesting L3 IGF-1 Info.

The general consensus on IGF1 seems to be that its benefits are as follows:

Increased Pump
Pumps are reported to be so severe that workouts are often cut short due to lack of ability to the muscle through the full range of motion�?�ouch

Gains
retention is increased, if IGF is used in a cycle I am not sure why, but IGF1 seems to make gains on a cycle stick with virtually no post cycle loss. Every bodybuilder I�??ve spoken with seems to think this for some reason. Most of them use drugs like Anadrol or Dianabol with it because of the amount of size attained with these drugs. The usual draw back to these drugs is that in most users there is a post cycle �??crash�?? that occurs, so the reasoning is to toss IGF1 into the stack and grow larger faster with out the post cycle crash blues.

Reverses testicular atrophy
Testicles if shrunken will return to �??full swing�?? so to speak even in the middle of a cycle. If not shrunken they will not shrink during the cycle. This may explain partially why gains are kept after the cycle.

Fatigue
Users report feeling drained and tired all day. This seems to be one of the negative side effects to IGF1, it will make you sleep longer and you will require more sleep at night to feel rested for the morning. This is common with high doses of HGH and exhibited in children, whose IGF1 levels are extraordinarily high. A child needs 4 hours more sleep than an adult on average does. This may be directly or indirectly related to IGF1 levels.

Stiffness
An almost arthritic feeling is commonly associated with high levels of HGH, well IGF1 has the exact same property. IGF1 will cause your hands, fingers and knuckles to ache this is one way you can be sure you got real IGF1.

IGF-1�??s Side effects
Every thing has a down side. To bake a cake ya gotta brake an egg. IGF1 is no exception. The drug used in larger quantity around the 100mcg+ range will cause headaches, occasional nausea and can contribute to low blood sugar or hypoglycemia in some users. Although I have never heard of this first hand I�??m sure its true.

IGF1 will attach its self to the lining of the intestine and cause atrophy of the gut. Every thing IGF1 touches will grow and you have a lot of receptors on the lining of the large intestine and inner wall of the abdominal well. This is what causes the GH gut look. You can easily avoid this by limiting your dosages and cycle lengths. IGF1 cycles should be kept to 4-6 weeks with 4-6 weeks off in-between. IGF-1 is considerably more powerful than HGH and you need to think of it along those lines as far as dosing goes. We all know what to much HGH can do over prolonged periods of usage. The Neanderthal look is definitely not going to win any shows this year. I would recommend 80 mcg a day for 4 weeks at a time you should get good results from that for a while. I don�??t know if you will need to up the dosage at any point, but I would think in the case of IGF1 it wouldn�??t matter. If 80mcg doesn�??t do it for ya, then bump it up to 100 You should definitely feel it at this point If not suspect the IGF1 as being fake. Beyond 120 mcg per day your asking for trouble, This compound demands as much respect as its sister amino Insulin.

Clinical Facts about IGF-1
IGF-1 is a polypeptide of 70 amino acids (7650 daltons), and is one of a number of related insulin-like growth factors present in the circulation. The molecule shows approximately 50% sequence homology with proinsulin and has a number of biological activities similar to insulin. IGF-1 is a mediator of longitudinal growth in humans or how tall you are capable of becoming. Serum IGF-1 concentrations are altered by age, nutritional status, body composition, and growth hormone secretion. A single basal IGF-1 level is useful in the assessment of short stature in children and in nutritional support studies of acutely ill patients. For the diagnosis of acromegaly, a single IGF-1 concentration is more reliable than a random hGH measurement (Oppizi, et al., 1986). IGF-1 can be used for the assessment of disease activity in acromegaly (Barkan, et al., 198.

Almost all (>95%) of serum IGF-1 circulates bound to specific IGF binding proteins (IGFBPs), of which six classes (IGFBPs 1-6) have been identified (Rudd, 1991). BP3 is thought to be the major binding protein.

I do believe i will be adding 1-2mg to my next cycle.

JJ

Well isn’t this fun stuff. How many handful of pills am I supposed to take every hour and how many bicep curls am I supposed to do to get hyooge? kthnxbai.

On a more serious note, I found something very interesting about IGF-1 as well. I have a guitar performance minor, so this made me excited to read that a peptide could potentially increase my playing skills.

[quote]GF1 may be of particular interests to athletes, as it may improve their ability to learn new skills and techniques relevant to their sport. You see, IGF is a known neuroprotector and neuropromotor(13)(14)(15), which means new skills could be learned more quickly with IGF use, and for the elderly, some of the cognitive effects of aging could be staved off or possibly halted entirely with administration of IGF1.
[/quote]

If it helps someone learn skills faster, then hell, I’ll just start taking IGF-1, practice guitar post-workout and become a guitar god!

[quote] JJ wrote:
Almost all (>95%) of serum IGF-1 circulates bound to specific IGF binding proteins (IGFBPs), of which six classes (IGFBPs 1-6) have been identified (Rudd, 1991). BP3 is thought to be the major binding protein.[/quote]

This explains a lot. Anybody know of a way(s) to inhibit this? There’s probably little to no research, but a bushy-theory would be killer.

What does it explain?

I’ve watched several acquaintances use IGF-1 and they all got very good gains (consistent with what you posted,) but they plateaued very quickly. At the time I figured it was maybe receptor down regulation, but that tidbit you posted shows it could have been IGFBP which was the culprit. No?

No… this binding isnt done in the long term.

IGF is only active for 10 minutes before being bound, L3IGF is larger, and thus is free for nearer 6 hours before getting bound.

this was my understanding of it.

This info wasnt meant to be talking about that - it is obviously an anecdotal based writing, and unprofessional IMO. But interesting none the less.

I will find a good one for its mode of action if you like.

It may be required for delivery to target tissues. Also, IGF-1 is a peptide and would likely be destroyed by serum proteases much faster if found mostly in free form.

http://www.muscletalk.co.uk/article-igf-1.aspx

read this one

Its injected subcutaneously am I correct Joe? Sounds like a hell of a drug.

Both - some sources say SC - for a systemic muscle building effect… but some say it is lesser.

then there is IM in the muscle, worked for localised growth - i think this only works in dosages of 100mcg 6x a day of the ‘old’ type of IGF - the unstable 10minute stuff.

Apparently, as igf now lasts 6 hours, when you IM it in those lagging biceps, it ends up moving all around the body anyway, growing ‘stuff’…

Hhmm, what if you injected it in your dick? Or my wifes tits? Or my wallet… or my house!

[quote] JJ wrote:
Both - some sources say SC - for a systemic muscle building effect… but some say it is lesser.

then there is IM in the muscle, worked for localised growth - i think this only works in dosages of 100mcg 6x a day of the ‘old’ type of IGF - the unstable 10minute stuff.

Apparently, as igf now lasts 6 hours, when you IM it in those lagging biceps, it ends up moving all around the body anyway, growing ‘stuff’…

Hhmm, what if you injected it in your dick? Or my wifes tits? Or my wallet… or my house![/quote]

I think we would need to inject your brain first to make that grow before we hit any of those other things.

What is the recommended dosage for it Joe? oops I forgot to do my own research. Dammit, I’m lazy.

All’s i know is what i have read over the last two days - 5.0 has done the stuff… bushy too i think…
but…

The BEST results are up at aroung 100mcg a day, split into 2 PWO bi-lateral jabs.

But this will make most sick, so you have to start at 20-40mcg a day.

Results can be seen at 40mcg a day, and 2mg will last the full recommended 50 days on used daily at that dose.

Distension will be seen above those doses i have also read.

Most of the olympia and top level IFBB pros we see with distended stomachs APPARENTLY have this from the non-Long R3 form of IGF-1, as the dosing schedule called for 600mcg a day in some cases, due to the riduculous half life… 10mins.

But this is not gospel - just what i have read of others accounts and some scientific BS…

J

PWO eh? so you have to follow the a slin like procedure? ie carb drink/sugar drink every 2 hours or so? well the distended stomach side effect just killed it for me.

no… why do you say that? it does have insulin like properties, and you can tstack them for that reason, BUT… it isnt as potent as slin in that regard AFAIK…

anyone else? I am not the fucking authority here, i know that much! come on?