Do you take any medication? Certain meds (particularly SSRI’s) can blunt and/or cancel out the euphoric, psychedelic, recreational effect MDMA induces. I can go into the mechanisms as to why if you’d like, but the post would be very lengthy.
Another question, how do you know the MDMA was pure? Plenty of people sell what is purported to be “pure” mdma, but it is one of the most commonly adulterated substances on the market. Many mdma analogues “mdxx” are probably relatively safe in an acute context in line with MDMA, but some substitutions (PMMA, PMA) etc are quite toxic.
Pain is a complex entity. You’ve got numerous types of pain. Neuropathic pain, pain mediated via inflammation (what type of inflammation?), Nociceptive pain etc. All have different treatments. The medication you’ve linked is a cox-2 inhibitor, otherwise known as a type of NSAID. We’ve all heard of NSAIDS (nonsteroidal anti inflammatory drugs)
Ibuprofen (nsaid) inhibits cox 1 and cox 2. The drug you’ve mentioned selectively/preferably inhibits cox 2 which is preferable to ibuprofen as the cox 1 enzyme mediated prostaglandin mediated gastric protection, thus peptic ulcer and/or stomach lining irritation risk is lower with etoricoxib. All of these drugs carry risks, look up “cox-2 inhibitors, cardiotoxicity”.
In laymen’s terms, cox-2 is somewhat responsible for inducing inflammation. Etoricoxib helped because pain induced post tonsillectomy is in part driven by inflammation. Though the pain would also be described as acute/nociceptive in nature, hence the use of opiates are also appropriate.
Codiene/tramadol aren’t particularly strong opiates and are subject to patient selectivity regarding how effective they are based upon cytochrome p450 polymorphisms. Both are pro drugs. Codiene is metabolised via cyp2d6, the primary analgesic end goal being morphine, for tramadol is desmethyltramadol.
If you have a genetic mutation (something like 4% of the population will) that means you are a poor cyp2d6 metabolizer, codiene and tramadol won’t do shit. If you are an ultra-rapid cyp2d6 metabolizer like I am, the effect will be more pronounced (and potentially dangerous).
The route of pain management is dependent on the type of pain
You’ve got medications for neuropathic pain (I can go into the pharmacokinetics if you wish, but this post is already getting way too long) like pregabalin, gabapentin, carbemazepine, SNRI’s/SSRI’s (yes, they can and are used for pain management… Not just depression) etc. Anti-inflammatory drugs like NSAIDS (cox-2 inhibitors), corticosteroids, NDMA receptor antagonists (well… Just ketamine for pain management), opiate/opioid painkillers and more
We have a wide variety of drugs used for pain. For debilitating, severe pain in an acute context like post surgical pain, for a fracture etc however opiates will always be king