I don’t actually have any bad weed stories… I have one wherein my cannabis was laced with angel dust (second time ever using), but wasn’t a “bad” story per se
I have quite a few terrible stories regarding alcohol… one involving getting very drunk at a party, coming home but my parents had guests over (keep in mind I’m at the legal drinking age here at this point, payed for all the booze myself)… I get home but they’re still awake at 2am… the guests want to talk to me… I start talking, they immediately realise I’m smashed and start laughing at me… The next day I get the biggest scolding from my parents “you were drunk, they were around, do you know how embarrassing this is for us… I’ve never seen you that drunk… ever”…
No, but I did post a study up earlier on this thread regarding the effect of frequent marijuana use on myocardial structure/function
Now, I have chronic pain (fibromyalgia, BJHMS, post surgical nerve damage) etc… I find low dosages help tremendously, but I’m not going to resort to frequent cannabis use as it makes me feel spacey/demotivated, even in low dosages… high dosages actually appear to trigger muscle spasm/make things worse
I found in Canada however that milder strains (something called great white shark with like 6 percent THC 13 percent CBD) were FANTASTIC for chronic pain… almost as good as strong narcotic painkillers such as oxycodone, tapentadol etc.
I’ve tried all three of these… Ketamine like… twice… whilst in Europe… don’t tell anyone though…
The notion of psychedelics and 5ht2b receptor mediated cardiotoxicity is incredibly concerning. There is one study in which participants who had used MDMA weekly for the past six years had a very high incidence of valvular heart disease… Now MDMA also induces hypertension, a hyperadrenergic state and resultant tachycardia etc… but it’s a serious concern for those who like to microdose psychedelics… serotonergic psychedelics all have affinity for this receptor.
I can’t see ketamine being used for anything unless the dosage is incredibly low, well below a sub anaesthetic dose, it’s far too incapacitating… if you’ve ever used it you’ll know what I’m talking about
Same goes with psychedelics, I’ve seen the studies in which a single treatment session amoreliates symptomatology stemming from treatment resistant depression, PTSD for years afterwards, and yes, perhaps there is significant value here (I actually found there to be significant therapeutic value within trying shrooms in Amsterdam)… Had a few breakthroughs regarding past events/things that I harboured insecurities over, it was one of the main reasons I actually no longer have significant social anxiety… at least that’s what I chalk it up to.
Ketamine stimulates the sympathetic nervous system in a dose dependent manner despite being classified as a depressant. Similarly to alcohol (and cannabis) it is a depressant substance that increases heart rate… rodent models indicate long term use of ketamine induces cardiotoxicity (that can be ameliorated via the use of beta blockers) but as I’m sure you know rodent models are flawed in relation to differing antioxidant, elimination/metabolic pathways, differing receptors at times (for instance rodent contain 3HSD in skeletal muscle, humans don’t… thus DHT is anabolic within skeletal muscle for rodents but not us as DHT is inactivated into DIOL metabolites within skeletal muscles harbouring little to no direct anabolic activity)… still given the dramatic increases in HR/BP stemming from ketamine I’d tread very carefully… also, which desirable effects are present from which isomer (racemic vs S+ isomer?)… Esketamine is currently marketed for treatment resistant depression if I recall
I do think psychedelics could be the next big thing regarding treatment resistant depression, far less frequent dosing and fewer side effects… but I’d say tread carefully… I am for decriminalisation though, here you’ll easily get a prison sentence if caught with say, over a few grams of shrooms… any amount will net you a certain court date and probable criminal record… but the chances of getting caught are minute