Start of Experiment: Estradiol Valerate

Just for clarity are you saying 60mg test is your favorite amount, or was that another of the listed prescriptions thrown out there?

No man Im just ā€œmaking funā€ of the phenomena we have in this community where everyone has their own theories what actually is the best, and what will work for everyone.

Or well, im just fucking around really. Ive been there done that myself.

For example, NPP only gave me insane boners, but apparently it doesnt work for everyone.

E2 works FUCKING GREAT for me, but im sure it doesnt work for everyone.

Point is, gotta experiment and try out lots of shit to find whats optimal for you, even to the extremes sometimes, it seems.

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Yeah im not going to be surprised if/when we find out blood levels are not solely or even partially responsible for many effects or desired states we seek with these compounds. People get such different results from deca vs npp for example, or test prop v cyp, or arimidex vs e2v. It feels like a gambling machine, no one variable means much of anything and everyone’s set of variables is wildly different but when something clicks you ride with it and stop fucking around, lol.

Like I understand trying to get the body’s chemicals into ranges or ratios commonly used to effect by the body naturally. But what about pulses, curves, rhythms, receptors, the psychology interpreting the physiology. Two guys with the same physical starting point will experience ā€œconfidenceā€ ā€œwell beingā€ ā€œsex driveā€ or ā€œcognitionā€ differently much like twins raised in different countries will likely have different tastes, languages, and hobbies even if given the same basic resources. Why does it make more sense to raise or lower a constant level of a hormone to seek its desired output when that hormone isn’t received in a steady state naturally? There’s got to be something to receiving signals in a daily capacity that matters on a timetable greater than one day. I mean the effects of a significant daily spike and trough have got to allow the body to establish some sort of better processing than soaking it in the same level of hormones all the time. Female fertility, a consistent regular monthly process, dependent on hormones, impossible if all of them remained at steady levels. Im seriously betting on the daily fluctuations having allowed your body to make better sense of the e2 and, after three weeks, that produced results beyond the scope of morning to evening. At my bar, we take big shipments daily, but if we took massive shipment monthly or small shipments every fifteen minutes nobody would be able to function.

Yes man.

I envy those guys who just ā€œtake a shot of test a weekā€ and feel great. IE, great libido, ā€œconfidenceā€, well being, energy etc.

I know plenty those in my gym.

They can even do whatever, like 1g test a week and some dbol and maybe add masteron randomly and they never seem ā€œoffā€, or ā€œlow energy due to androgen overloadā€ or complain about ā€œno sex driveā€, they just happy go lucky lift weight and love live.

And then, we have cases like me, who now have to pop e2 pills to even tolerate testosterone not shutting my cock off.

LOL

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Whatever. I’ll try it and if it works we can start Team Estradialed.

Any updates on this? Im currently sorting out dosages of my hormone replacement

test prop 15-20mg
Combo thyroid hormone t3/t4
injectable estradiol valerate

I’m someone whose e2 is at 20 when tt is 1100. I’ve noticed e2 does increase libido but haven’t been doing it long enough to test yet and haven’t found a sweet spot where dick works properly. But it has actually allowed me to feel true arousal vs my normal forced arousal I’ve had for years. Also it has brought back my ability to have dreams while sleeping. I did notice that my starting dose made me go hypothyroid and had to add t3 to my normal t4. Currently Lowering dose and will test at some point in next few months. Also it is known that t3 will increase aromatase and also increase clearance of e2 so maybe if I get thyroid dialed I won’t need exogenous e2. Im more confident than ever that the results I want are somewhere within the combo of these three compounds.

Newer studies show a 1-2% increase risk of PCa breast cancer in women on estrogen therapy, but on the flip side, women without estrogen therapy show a 62% increased risk of stroke as well as other high risk diseases!

The Women’s Initiative is to blame for false beliefs that estrogen therapy is bad for women, because they only focused on synthetic estrogens and not bioidentical hormones, but labeled all hormones bad.

The way it see it, if estrogen therapy was bad for women, then TRT would be bad for men.

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I am still wondering what the solution for me would be if I am to test out this theory and it works. I don’t seem to be a heavy aromitizer and only ever got into the 40s (48) in E2 doing a hefty TRT dose and HCG. My TT was 1272 though. My body on average tends to push a ratio of around 40:1.

When I did every 5 day injections my trough did show a ratio of 818/38. But that’s only trough and I didn’t feel good. That was the smallest ratio I was able to ever achieve, IE ratio of 21. I was doing a half inch needle to glute of 100mg so maybe it was subq? It was good at first until it wasn’t.

I do feel better on lower doses though… in which I doubt I hit some magical ratio, if anything my E2 is in the teens.

40:1 is about 20% better than mine at 50:1. Very dht dominant low aromatizer. I’d say 30:1 is my initial goal. I believe it’s thyroid related potentially or nutrition too can be implicated for example - copper. I’ve seen guys use t3 only and get much higher e2 numbers. Between thyroid and direct supplementation is where I’m at with this. Using injectable as oral e2 for me cannot be deemed long term plan. Very interesting thread/experiment by OP though!

Plus if 2 years into Menopause and without proper hormone balance the brain starts degenerative processes which are irreversable. My heart goes with every women which goes to GP with massive MP/hormonal issues and all they get offered are antidepressant. Unless you do your own homework and demand care again and again. I’ve listened to top UK women HRT expert lady and liked the way she said about this particular issue with breast cancer and E2 use in very simple words. If in non-HRT group women get breast cancer the stats go something like 4 in 1000, but if in HRT group thats 5 from 1000. So the risk is miniscule IMHO compared to what might happen if you fail to restore proper hormone balance and fix your E2/T/Prog ratios for proper cognitive, cardiovascular, sexual, etc, benefits/protection.

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This is very interesteing.

So I tried going off the estro pills.

Been off for 8 days.

Halflife is very short.

Penis STILL gets very very hard.

Maybe I dont need em no more now?

Maybe the estrogen shit fixed my fucked up estrogen receptors or something?

SUPER weird

Ima continue being off em se what happends

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Keep us updated. I think I asked @highpull about his patients if the estrogen therapy was for ever, he said no. Hopefully he can confirm it was an old thread.

Correct. There have not been very many, but I am positive none stayed on it for an extended period.

I wonder whats up with that shit. Maybe u need to put the estrogen receptors to overdrive or sum?

The heck is going on here, this is crazy, lol.

ALL I KNOW is i crushed my estrogen hardcore in the very beginning of my ā€œcareerā€, using AIs like a mad mad mad man.

So did I, and I remember reading a study, in women, that showed that prolonged periods of near-zero e2 resulted in the destruction of DA receptors. Returning their e2 to normal did not guarantee the DA receptors came back. Could it be that overloading with e2 for a period of time did the trick tho?

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Before TRT my E2 was untraceable at <12.

I was a heavy chronic vape user, I heard that nicotine can act as an AI. When I started chronic vaping for years and years everything went down hill for me eventually. Mainly besides libido and erections, I had developed a sort of apathy which is worse than being sad or temporarily depressed, you just don’t give a crap about anything.

Wonder if i also messed things up in that regard, or was my untraceable natty E2 just a coincidence.

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Oh yeah man, it’s not just being ā€œsadā€. It’s like despair. I was living at home at the time and it was hard to explain to my folks what I felt. Once I realized that it was the e2, and I got it fixed, things got way better.

I guess it’s hard to know for sure, there’s a lot of variables at play here. But I’m sure it’s a large part of it