Just because the drug targets the pathway doesn’t mean it completely shuts it off. For some people for it to be completely shut down you would need to take a larger anounr if the drug which has its own issues.
Mental toughness has a lot to do with it. If you ca tout the fork down you need to sack up and make a change. These drugs are not magic. You are still in control of yourself. You have to make the choice to eat it not or to eat the proper foods.
Have you ever used them?
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yes I have been taking tirzepatide for just over a year now as described in the thread I made over here Setting realistic goals and expectations after starting over - #41 by MM_CK and I have been doing my best to follow the primary research on the topic of GLP-1’s, especially tirzepatide (Mounjaro / Zepbound), in order to be an “informed consumer”. I am also very interested in hearing about retratrutide since its getting a lot of hype from bodybuilding circles it seems and your comments on that are very helpful.
Trying to attribute appetite control to “mental toughness” is a pretty ignorant sentiment I think especially in regards to the topic of seeking appetite control from GLP-1’s. Its like trying to shame someone who wants to go to the gym & start lifting for the first time for being “weak” or “out of shape”. Its also incredibly ignorant because the excess “mental toughness” that you supposedly attribute to yourself is the same is the same attribute that is directly given by GLP-1 treatment. So in a lot of ways, its like bragging that you are big & strong after taking drugs, to people who have not yet taken drugs. And its a wishy-washy subjective way to anthropomorphize something that is ultimately just another biological pathway and is controlled as such.
The desire to eat or not eat has absolutely nothing to do with how “tough” you are. It has to do with the various drivers of eating behavior with iirc are typically ascribed to external environmental factors, and intrinsic biological factors, among other things. And for what its worth, my experience with tirzepatide has been that if you are trying to lose weight, “eating the proper foods” had nearly zero significance. I was eating cookies and pudding every morning in order to keep from losing more weight, until I finally reduced my dosage. On the other hand, I did have to carefully evaluate and track my eating again when I shifted gears to try and re-gain weight while still taking the medication.
also I think its worth pointing out that the situation presented in this thread seems a little odd in a couple different ways. OP describes having had a gastrectomy ; this is a pretty serious medical procedure. It suggests to me that OP’s challenges with eating are severe enough to warrant surgery. And it also suggests that OP is serious enough about addressing their eating challenges to consider surgery in the first place. And it also suggests to me that if OP was able to obtain such a procedure then surely they would have medical care and likely medical coverage of some kind? Which makes it seem even more odd that OP would thus be seeking to obtain off-label black market research chemicals for personal use. I think this is important to point out, because if OP had disordered eating to a large enough degree to warrant surgery then I think they definitely need to be seeking medical oversight with GLP-1. OP says they “previously tried semaglutide” but its not clear if this was following standard medical guidelines & with doctor oversight, or if it was self-obtained and self-dosed.
Anecdotally, I have met some folks who claimed to be “non-responders” to semaglutide, and I have heard of people who did not respond much to semaglutide who responded well to tirzepatide. Maybe because the former is a single-agonist and the latter is a dual-agonist? No clue. But it is my understanding that across GLP-1’s, the strength of response can indeed vary based on the individual and it could be that a larger dose was needed as @s.gentz says. This is not clear from OP and is something that would require medical oversight from a doctor. Which is ultimately what I think is best for OP in this situation; seeking medical oversight instead of trying to self dose with research chemicals. This is especially underscored by how easy it is to get such professional medical help with GLP-1’s. There are online clinics that make it super easy to connect with a doctor, discuss diagnosis & treatment options, then get treatment with regular follow-up doctor visits (electronic) and ongoing counseling for diet & exercise to support any medications prescribed. Considering how proactive OP is being with their health, this seems like the more logical route to take, and its not clear if this sort of avenue has been explored or considered yet
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What i’m getting at by saying this is that the drug can’t stop you from eating. You have to stop yourself. Simple as that. I think your reading too much into it.
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Until you lose weight, and then you are supposed to stop taking them.
So the exact pathway that allowed you to lose weight in the first place is now not functioning.
Was that non-boomer enough for you, tard ass?
What is it with the glp1 dick riders?
Jesus
The supplier can provide HPLC tests for most products, which is not an issue in itself when validated reference standards are available for comparison. My concern with the tests for retatrutide is that such standards don’t yet exist, as Reta is not on the market. For testosterone and similar compounds, I can rely on the certificates provided - plus, the results speak for themselves.
Thank you for your long and insightful reply. You touched on what I didn’t have the energy to go into in my earlier answers - the topic is highly multifaceted and more than a little polarizing. Until I experienced severe depression firsthand, I was convinced that all you needed to do was “suck it up,” put your head down, and grind. I now know better. And truthfully, no one could have convinced me otherwise back then.
I see my cravings for sweets and chocolate in a similar way, which is why I no longer engage in these types of discussions. It simply isn’t possible to truly understand unless you’re affected yourself, and I have more important uses for my limited energy.
That said, I do agree with some of the points @s.gentz is making - there will always be a need for a certain amount of willpower. My hope with reta, however, is that instead of constantly having to fight a raging wildfire (which, historically, I’ve only been able to do for so long), the medication could help reduce that to a manageable glow. That, at least, is something I’m convinced I could handle.
Therapy, sleeve gastrectomy, more therapy, and physician-assisted semaglutide are only a few of the approaches I’ve tried to get on top of this issue. Altogether, they’ve helped me maintain a reasonably stable surplus of 15–25 kg (33-55 lbs) of body fat, depending on what my goal body-fat percentage would be. Not the end of the world, but also less than ideal - especially now, at 51 with a hip replacement coming up. It would certainly be beneficial to carry around as little excess weight as possible moving forward.
Have you tried a sugar fast to reset your cravings? Because the point everyone is trying to make is that, as they say in addiction treatment, “if nothing changes, nothing changes.” The sleeve did the same thing the GLPs are doing - to slow the digestion process to increase satiety.
The dietary changes - a move away from sugar and processed foods - would be the first step, then if weight loss is still an issue, take a second step to manage hunger and food noise.
Ideally you make decisions about Reta AFTER grapes have become the “food noise” you can’t manage - because at that point, you’re talking about hunger, not your body’s cravings for highly palatable foods, which, like social media and cigarettes, are lab-designed to produce cravings.
Also, I’m a therapist, and I can tell you that the effectiveness of therapy depends on both the competence of the provider and the patient’s willingness to change. Not all therapists are up to the job, in my opinion. And not all patients come prepared to experiment with the changes that might allow progress.
I’ve been too busy to post, but the presentation of your issues screams therapy. Your issues are not physiological, because you’ve already addressed that piece, your issue is emotional, and I would label it “learned helplessness.” Same as an angry guy who is looking at divorce but doesn’t feel that there’s anything to be done about his temper. “That’s just the way I am.”
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Yeah I actually did!
Thank you for taking the time to write - much appreciated! I’ve certainly tried cutting out sugar completely, and it does work for a while, much like several other approaches. As long as motivation is high, things go well, but in the end, nature always seems to win. Since the retatrutide is already ordered, I’ll give it a try. Still, thank you - I’ll make sure to manage my expectations. It’s quite possible I’ll end up in therapy again if reta works the way you expect it to.
I actually eat very clean overall, apart from the excessive amounts of sweets and chocolate, so there isn’t much to improve there. And while the effects of a sleeve gastrectomy overlap with those of GLP-1 agonists, the mechanism differs: instead of slowing gastric emptying, the sleeve actually speeds it up due to its reduced size. The reduction in food noise and hunger comes from two things - the stomach reacting to smaller volumes of food and the much lower release of ghrelin. My (possibly vain) hope is that the two additional mechanisms in reta, compared to semaglutide, will make a meaningful difference.
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Seriously?
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Seriously.
Then you don’t eat well. GLP drugs are not gonna fix this.
They may not have fixed me, but they certainly helped. It is hard to describe how it takes away pleasure from a lot of things.
I actually dont do drugs that often, apart from the excessive amounts of crack and meth
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Hmmm…seems like you might have a problem. GLPs seem to help with addictions/compulsions
No, we have methadone for that
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