[quote]retailboy wrote:
Christian Thibaudeau wrote:
retailboy wrote:
Thibs,
The one scientific theory behind this new pre-workout nutrition you have presented has been that catecholamines blunt the effects of insulin - correct me if I’m wrong please.
My 7+ years of formal education in the biology/clinical sector has taught me no such direct pathway. I have actually been taught that with increase catecholamines your muscles increase the uptake of glucose which improves the effects of insulin.
Since it seems T-Nation’s next big supplement and your new pre/intra/post workout nutrition protocol seem to hinge greatly on the evidence behind them - I was hoping you had ANY type of scientific backing for either instead of just anecdotal (I understand that science is behind in this area of research but still there should be research that supports some of the basics of your protocol - even if it is as simple as by what pathway the catecholamines blunt insulin).
Side note: I have been getting better results over the past two years since I’ve switched to ‘high’ pre and intra carbohydrate intake from the typical post-workout protocol.
Thank you for your time Thibs!
David
Well, since you have been witnessing the powerful effects yourself, why the need for a study?
i: 10.1172/JCI107887.
PMCID: PMC301695
Copyright notice
Glucagon Secretion from the Perfused Rat Pancreas STUDIES WITH GLUCOSE AND CATECHOLAMINES
Gordon C. Weir, Stephen D. Knowlton, and Donald B. Martin
Diabetes Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114
Diabetes Unit Harvard Medical School, Boston, Massachusetts 02114
This article has been cited by other articles in PMC.
Abstract
The isolated in situ perfused rat pancreas was used to study glucose and catecholamine control of glucagon secretion, and to investigate the possible role of endogenous cyclic AMP as a mediator of this secretory process. When perfusate glucose was acutely dropped from 100 to 25 mg/100 ml, glucagon was released in a biphasic pattern with an early spike and a later plateau-like response. 300 mg/100 ml glucose suppressed glucagon secretion to near the detection limit of the radioimmunoassay (15 pg/ml). When perfusate glucose was dropped from 300 to 25 mg/100 ml, a delayed, relatively small peak occurred suggesting persisting alpha cell suppression by prior high glucose exposure. 2-Deoxy d-glucose stimulated glucagon secretion and inhibited insulin secretion.
Glucagon was secreted in a biphasic pattern in response to both 2.7 Ã??? 10-7 M epinephrine and norepinephrine. The glucagon response to epinephrine was markedly suppressed by glucose at 300 mg/100 ml, and the biphasic response pattern was obliterated. Glucose evoked a two-phase insulin secretory pattern, and the second phase was markedly and rapidly inhibited by epinephrine. Pancreases were perfused with glucose at 300 mg/100 ml which was then lowered to 80 mg/100 ml. 5 min later, epinephrine was infused and definite blunting of the first-phase spike occurred. 10 mM theophylline produced modest rapid uniphasic stimulation of glucagon release, and, in addition, caused enhancement of epinephrine-stimulated glucagon release. An inhibitory influence upon epinephrine-stimulated glucagon was observed as well. Insulin secretion was stimulated by 10 mM theophylline, and this stimulation was inhibited by epinephrine.
You get the point…
Thibs,
Thanks for the response.
I was wondering the scientific backing because I believe if someone is going to have a product and put so much into advertising, production, etc. that there should be some scientific support (I give my hats off to T-Nation for doing such a great job with this with all their products). But I haven’t seen any support for your short response in an earlier post on catecholamines - I actually have conducted studies that assumed and been taught the opposite. But thank you for pointing out to me these studies they definitely show the correlation you spoke of. There is research that they actually raise the glucose in the blood stream.
The one problem I have is the half-life of catecholamines are only 40~ seconds. Do you believe the adrenals continue to produce them even 10 minutes after a workout (when someone wold take a post-workout nutrition)?
Thanks Coach!
Dave[/quote]
Oh yes… they stay elevated for quite some time after a workout. And the more intense, the longer the elevation. Obviously it varies from one individual to the other, but generally they stay up until heart rate is back to resting levels.
I have some data about this somewhere and will try to dig it up.