I have been doing a cycle of test cyp and EQ 400mg a week of each for 3 weeks now. And in the last weeek my prostate has been getting swollen. I have to piss all of the time and when Im done I can wash my hands and have to go again. Does this go away or is there anything that I can take to get rid of this side effect? I have some extra Nolva that I can throw in if I need to. Please advise while I go piss again.
E2 is now considered to be a bigger driver of BPH than T or DHT. There are risks that are not temporary.
You should be keeping your E2 levels controlled in any case for several reasons.
Anastrozole all through a cycle and PCT, with a reduced amount well pass PCT to manage estrogen rebound.
Not taking an AI is, to be polite, sub optimal.
SERMs are just that, Selective. I do not know if they have any effect on the actions of E on the prostate. Better to control E, rather than mask its effects with some tissues. Nolva may not solve the problem or may have limited effects.
I don’t think that you should ever expose yourself to uncontrolled E again when cycling.
When urine flow becomes marginal, the effects of other drugs and some foods can create a make or break situation. Pain killers for one. To see if there is an allergenic type component to this, take a strong antihistamine if available. Note that antihistamines can have some adverse effects as well. Note if urine flow improves with the antihistamine. If so, you might want to think about what you are getting into your system that is making things worse.
I think I understand you but let me rephrase in dumb weightlifter lehamn terms. Ok I could be screwing myself up if I am getting these side effects. I need to get some Arimidex for my next cycle?? That should stop the E rebound…correct. I have done a cycle of Equipoise only and had no side effects, but also no major gains as well. Also I have sinus problems and I have been taking an antihistimine already. So i think that its just the estrogen. Now, what should I do? I can get some Arimidex but it will take a couple of weeks. SHould I discontinue the Test until I get Arimidex and keep going with the Equipoise? I definately dont want to screw my prostate up and dont want any problems. Do you think that I should get my prostate checked? I have never had any problems with it before this cycle. I appreciate all of your help.
Antihistamines can cause enlarged prostate symptoms as well.
KSman is right about estrogen causing your problems. Increased estrogen and BPH go hand in hand.
How old are you?
Could this be a urinary tract infection?
[quote]BSC819 wrote:
I have been doing a cycle of test cyp and EQ 400mg a week of each for 3 weeks now. And in the last weeek my prostate has been getting swollen. I have to piss all of the time and when Im done I can wash my hands and have to go again. Does this go away or is there anything that I can take to get rid of this side effect? I have some extra Nolva that I can throw in if I need to. Please advise while I go piss again.[/quote]
You say your prostate is getting swollen, did you have “the exam” to find this?
400mg a week seems pretty light for getting sides, especially at 3 weeks, but that doesnt mean you’re not overly sensative to test either.
So you piss alot, how much fluid are you taking in during the day? How is the stream when you go (any pain, are you having to force it, are you done when you’re done or dribble dribble dribble)? How many times during the night are you having to get out of bed to go?
[quote]DrakeKiller wrote:
BSC819 wrote:
I have been doing a cycle of test cyp and EQ 400mg a week of each for 3 weeks now. And in the last weeek my prostate has been getting swollen. I have to piss all of the time and when Im done I can wash my hands and have to go again. Does this go away or is there anything that I can take to get rid of this side effect? I have some extra Nolva that I can throw in if I need to. Please advise while I go piss again.
You say your prostate is getting swollen, did you have “the exam” to find this?
400mg a week seems pretty light for getting sides, especially at 3 weeks, but that doesnt mean you’re not overly sensative to test either.
So you piss alot, how much fluid are you taking in during the day? How is the stream when you go (any pain, are you having to force it, are you done when you’re done or dribble dribble dribble)? How many times during the night are you having to get out of bed to go?[/quote]
I am taking in a gallon or more of water a day and have been for 2 years now. My stream is still good, I do feel a little pressure in the tip (urethra area). I do dribble a little bit and I am getting out of bed mabye once a night, but thats still more than I ever have before.
I bought some Arimidex and I will take .25 ED with the rest of my cycle. I just have to wait 10 days for it to get here. I am going to lay off the test until I get it and just go with the EQ only. Now I dont have much experience with Arimidex, when should I stop using it?
I was going with Nolvadex only for PCT 40mg ED for 2 weeks/ 20mg ED for the next 2. I was going to start my PCT 2 weeks after last injection. Please let me know if there is anything else that I should do. O yeah, my cycle will last for 10 weeks.
[quote]BSC819 wrote:
DrakeKiller wrote:
BSC819 wrote:
I have been doing a cycle of test cyp and EQ 400mg a week of each for 3 weeks now. And in the last weeek my prostate has been getting swollen. I have to piss all of the time and when Im done I can wash my hands and have to go again. Does this go away or is there anything that I can take to get rid of this side effect? I have some extra Nolva that I can throw in if I need to. Please advise while I go piss again.
You say your prostate is getting swollen, did you have “the exam” to find this?
400mg a week seems pretty light for getting sides, especially at 3 weeks, but that doesnt mean you’re not overly sensative to test either.
So you piss alot, how much fluid are you taking in during the day? How is the stream when you go (any pain, are you having to force it, are you done when you’re done or dribble dribble dribble)? How many times during the night are you having to get out of bed to go?
I am taking in a gallon or more of water a day and have been for 2 years now. My stream is still good, I do feel a little pressure in the tip (urethra area). I do dribble a little bit and I am getting out of bed mabye once a night, but thats still more than I ever have before. I bought some Arimidex and I will take .25 ED with the rest of my cycle. I just have to wait 10 days for it to get here. I am going to lay off the test until I get it and just go with the EQ only. Now I dont have much experience with Arimidex, when should I stop using it? I was going with Nolvadex only for PCT 40mg ED for 2 weeks/ 20mg ED for the next 2. I was going to start my PCT 2 weeks after last injection. Please let me know if there is anything else that I should do. O yeah, my cycle will last for 10 weeks.[/quote]
Also I am 30 yrs old, and I dont think that it is a urinary tract infection. And no I havent had the anal finger probe yet. After my PCT and everything gets back to normal I will go have a physical and get my prostate checked, although I am not looking forward to it.
[quote]KSman wrote:
E2 is now considered to be a bigger driver of BPH than T or DHT. There are risks that are not temporary.
You should be keeping your E2 levels controlled in any case for several reasons.
Anastrozole all through a cycle and PCT, with a reduced amount well pass PCT to manage estrogen rebound.
…[/quote]
2 articles you may find interesting:
[i]
1: J Urol. 1995 Aug;154(2 Pt 1):399-401.
Comment in:
J Urol. 1995 Aug;154(2 Pt 1):402-3.
Placebo controlled double-blind study to test the efficacy of the aromatase
inhibitor atamestane in patients with benign prostatic hyperplasia not requiring
operation. The Schering 90.062 Study Group.
Gingell JC, Knönagel H, Kurth KH, Tunn UW.
Department of Urology, Southmead Hospital, Bristol, Great Britain.
PURPOSE: We tested the theoretical concept that a selective decrease in estrogens
has a beneficial therapeutic effect on established benign prostatic hyperplasia.
MATERIALS AND METHODS: In a double-blind study 160 patients from 14 centers were
randomized between 2 groups to receive either placebo or the aromatase inhibitor
atamestane (1-methyl-androsin-1,4 diene-3 17-dione, 400 mg. daily for 48 weeks).
RESULTS: The aromatase inhibitor decreased the mean estradiol level by
approximately 40% and estrone by 60%. The testosterone concentration increased by
more than 40% and dihydrotestosterone increased to 30%. Analysis of clinical
parameters showed no difference between placebo and atamestane. CONCLUSIONS: The
counter regulatory increase in androgens may counterbalance any positive effect
of the decrease in estrogens to preserve intraprostatic homeostasis.
2: Arch Androl. 2000 May-Jun;44(3):213-20.
Role of estrogens in human benign prostatic hyperplasia.
Sciarra F, Toscano V.
Department of Fisiopatologia Medica, II Endocrinologia, University of Rome La
Sapienza, Italy.
The aging process is associated with a progressive decline of plasma testosterone
levels, while estrone and estradiol remain unchanged and sex hormone binding
globulin (SHBG) increases, with reduction of bioavailable testosterone in
prostatic tissue with benign prostatic hyperplasia (BPH) the most important
androgen is dihydrotestosterone: with its receptors it is almost uniformly
distributed in the epithelial and stromal compartment and is not supranormal.
Intraprostatic estrogens and their receptors are elevated and concentrated in the
stroma. Androgens may act on the prostate indirectly through the production of
growth factors; in human BPH no clear evidence exists on the modulatory effect of
estrogens on bFGF, KGF and TGFbeta formation. A western diet, characterized by
high fat consumption, predisposes men to BPH, while a diet rich in flavonoids and
lignanes, containing phyto-estrogens, lowers this risk.
These data suggest that
in the medical treatment of BPH, antiestrogens or aromatase inhibitors may be
used: however, up to now the clinical results of this treatment are not promising
and the improvement of the obstructive symptoms does not exceed that of placebo.
A possible explanation of this unsatisfactory result could be that the estrogen
reduction secondary to the use of aromatase inhibitors is counterbalanced by the
rise of androgen precursors.
[/i]
Points:
-
Estrogens may promote stromal hypertrophy; DHT is a driver of both stromal and gland hypertrophy.
-
There ain’t no free lunch: good aromatase inhibitors drive up T and DHT and clinical benefit cannot be found for BPH. Intact men with BPH may be as bad or worse on AIs; or alternatively, estrogen reduction doesn’t work and higher T levels don’t hurt enough to measure a difference.
-
If I had my way, I would test a “DHT clamp:” AI and dutasteride together. T may still, at a lower power, stimulate BPH perhaps the therapeutic margin would be worthwhile. (A test of biologic principal, not of therapy. Kids, don’t try this at home.)
[quote]bushidobadboy wrote:
Good post Dr. S. though it seems a shame that AIs are not the quick fix that they may seem to be.
Once again, the intricacies of the human body confound easy solutions.
Bushy[/quote]
Well I have been taking Saw Palmetto and Nolva (20mg ED) and the problem seems to be going away. Also My sinuses were a little stuffy and I was using Afrin when I started having the problems. I noticed that on the bottle of afrin, it has numberous things about “do not use if you have an enlarged prostate” “discontine use if it causes urinary problems” several quotes about urinary problems. Maybe the Afrin caused some kind of problem because it seems to be going away after not using the Afrin for a couple of days. I guess that I have to make a decision, if I want my pecker or nose to drip??