Low SHBG Experimenting with One Large Shot E10D

Pharma TRT
42

Here’s the thing, low SHBG is associated with metabolic syndrome, TRT isn’t a panacea or cure all. I recall a few members with metabolic syndrome who went on TRT and didn’t fully recover and are having the same issues you are.

The metabolic syndrome, not the low SHBG is causing your symptoms. The low SHBG is a symptom of metabolic syndrome. You’re treating the symptom, not the disease.

You can play around with your protocol all you want, it will be futile. The only way you have a chance to get the full benefits to TRT is treating the metabolic syndrome or whatever is causing your issues.

Low SHBG is also strongly linked with inflammation, which is what lowers the SHBG in the first place. Obsessively playing with the protocol isn’t going to change that.

43

How do you treat metabolic syndrome out of interest?

45

Looked up metabolic syndrome.

I have been working out for 32 years straight. At least 5 days a week. I’m not fat. Blood pressure is normal.

I’m not sure what else to rule out

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I recently watched a doctor put forth a question on Intragram, showing a guy who is clearly a gym dude, a stud, and a morbidly obese man, and the question was, which one do you think has disease.

The morbidly obese man had no disease, the fit stud of a man had all the diseases. So doesn’t matter what you look like, how lean you are, disease doesn’t discriminate.

There are a lot of diseases that are idiopathic, meaning, no known cause.

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47

How does one even know for certain if he has metabolic syndrome? Just based off symptoms?

48

Dyslipidemia
Large waist
Elevated BP
Elevated fasting glucose

49

This is what I’ve observed as well, I have guys with single digit SHBG doing fine dosing once weekly and guys with elevated SHBG who prefer multiple weekly injections, and the other way around.

When this comes up at medical conferences, it is not much of a consideration except initially when determining dose volume, but not frequency. Because of its association with metabolic syndrome (also mentioned by systemlord above) many say you never want to lower SHBG.

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50

As in higher dose for higher SHBG and lower dose for lower SHBG I assume?

51

I am a relatively low SHBG guy, hovering around 20, and having tried once weekly and daily I noticed no differnece in either, both in terms of how I felt or its impact on SHBG. Even varying doseages of 80mg to 175mg saw no difference in SHBG. The only thing that seems to reduce it is if I add DHT derivatives, knocking it down to single digits, but quickly comes back up to 20. This was also my SHBG when I was natty. So, in my case at least, true TRT hasnt affected my SHBG in any way.

52

You’re an outlier.

53

Yeah, perhaps. Im sure if I went on a cycle of 500mg Test plus it may have a negative impact, but seems if I keep it within TRT realms it doesnt impact

54

I was using 500 test-e/week 2x shot schedule with extra tren. While 500 test-e I needed arimidex or aromasin. And very very rarely I crashed my e2.

When I tried low test high tren with enanth test, and addition to proviron, my knees and back started to hurt. 15.11.2022 november.

Then switched to test-p 40mg ed or so, my knees and back never healed. Tried test-ace 50mg ed, still knee and back pain.

I have started estradiol valerate pills, and tried with 25mg test-ace a day. 4mg AM 4mg PM, apetite went up really good, libido upped some, knees and back still hurting.
Pills are more expensive than my homebrewed test-a, tren-a, test-cyp. And from excel-m Coconutz said, estradiol pills only effects for hours, had to take it several times a day. Even with estradiol valerate injection, he had to use it 2 times a day, and this seems sucks too.

I injected 25mg npps for 4 days, and on the third day my pains disappeared.

I don’t know should I use more test-e or cyp. Or more npp for e2 receptor sensitization, dht blocking and extra aromatization. Back then while I was using moderate amount of long ester testosterone I needed AI’s. Now I inject 2.5ml test-e in 2 days, I dont feel any e2 or so.

I just want to maintain lowest testosterone that I can feel normal.
Test-e 500 + tren
Libido was 10/10
Apetite 8-9/10

Test-ace or prop + tren
Libido 6-8/10
Apetite 5-7/10

My natural hormone levels were:
2018
Total test 3.50ng/ml (1,75-7.81)
Estradiol 17 pg/ml (<47)

2019
Total test 3.45ng/ml

2021
Total test 3.61ng/ml
Free test 6.83ng/L (4.5-42)

28.02.2022 500 test-e and some anadrol, never touched dhts proviron or masteron and never touched tren yet.
SHBG 8.18mmol/L (10-57)

06.04.2023 using tren for 1 years this time, and proviron on and off.
SHBG 4.5mmol/L (10-57)

Also I dont have sensitive e2 test on my hospital, and being on tren, I just rely on symptoms.

If I continue to inject 1ml test-e/day will my e2 start to raise again?
Or If I just wait and inject 2ml test-e E7D, my e2 starts to creep up? Is there a frontloading way to it?

55

Androgens can drive SHBG down, but it is not a given. However, the majority of guys I see with low SHBG were AAS users in the day. Anabolics at PED levels will decrease SHBG significantly. TRT guys, generally not so much.

I need to put some data together, but off the top of my head, I see very little change once starting TRT. Some drop a little at first, only to see it return to the original level.

Personally, mine has not changed.

56

Correct.

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@highpull How many guys do you have that feel better on less frequent injections? As in even better on E5D or E7D than E3.5D?

I’ve found when I was doing 160mg/week in E3.5D injections that even though I had more “physical” side effects (higher BP, headaches, bloating, etc…) I felt a lot better and had more drive/ambition/libido.

On daily 22mg/day (154mg/week, so basically same as 160mg/week), I felt completely flat. Zero drive, couldn’t even get myself to work out anymore even though as a natural with bottom of the range Free T I could still push myself in the gym (with no results though) 5 days/week.

Is that something you see commonly?

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58

How often u inject, how much and even WHERE seem to have a great effect on how you feel.

Ive done so much shit during these years and Ima tell you what i took that resulted in my drive for success was insane and my need for sleep was so low i could function on full gear goin 5 hours a night of sleep:

Total of 240mg of test e a week.
Split 3 times a week.
80mg each time where 60mg was delt IM and 20mg was subQ.
600mg of vitamine b6 every day split in 3 doses.

This has my motivation and jezt for life THRU THE ROOF, i felt like a machine.

Very, very specific protocol.

I have not been able to replicate this with any other protocol.

Point is, again, how often u inject, how much each time abd even where, can have a great fking impact on how u feel.

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59

I think there is something to cranking our bodies temporarily over the limit then giving a rest falling below the limit. Total speculation and just bro hypothesis. I felt like absolute death on same dose but higher frequency. Something in my body that prefers bigger less frequent shots. Just my personal anecdote Xmg weekly once a week > Xmg weekly ED/EOD.

Maybe something with DHT conversion maybe something with skewing ratios to a more favorable range. No idea but I know there is something going on.

60

What I have seen is contrary to what you see reported on internet boards. While changing dose frequency is not unheard of, it is not common. Most stay with whatever frequency they started. Of those that change, most are doing fine, feeling better and getting good results, but are simply in a continuous improvement mode. No matter how good they are doing, they are constantly trying to do better. I suppose it can be fun to experiment.

In some cases, and maybe yours, as @kazuya_mishima1 mentioned below, you do better with the higher peaks and are not sensitive to the valleys.

While this won’t be a popular opinion, I believe many overthink this. Outliers aside, I have not seen that injection frequency and location have significant impact on TRT results. I like to read stories here, but generally they are not what I see in practice.

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61

This needs to be spread all across the forums.

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62

Been injecting e2 valerate 2mg everyday, it’s the 7th day of that.
While doing this, until I inject test-cyp 250mg, I just felt my emptyness transformed to calmness, but libido or great mood never came.
Also injected 50mg npp and 20mg tren everyday.
And I injected 250mg cyp again too, will do 500mg e7d-e10d with low dose tren. Gonna drop npp 5mg a day.

After test shots, I felt better. Satisfaction came, want to go gym improve also.

Just want to try this protocol, with addition e2 and tren. Do you think low dose tren or npp contraindicates the protocol?

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