Josht9210's TRT Log - Depersonalization, Panic Disorder, Agoraphobia, Etc

Well I have been watching your progress since day 1. And I have always been like you nervous type, but it was completely normal nervousness. After my natural BB I am constantly wired and even dont have racing thoughts.
I have tried to lower my dosage of Cipralex from 10 to 5 mg I feel more alive, but I have constant feeling that my head is squeezed by something mainly on the right side and my neck hurts and I feel more in tenste. I dont have any major stressors in my life. Good job, girlfriend who supports me even that we havent had sex for a long time cause of my tiredness and dead libido.Money wise good.
I can tolerate this tense feeling inside but it sucks and I understand you man.

IMO You should check your cortisol levels with 4 saliva cortisol test, and do something about your thyroid. Try cytomel 3x times a day or T3/T4 combo or NP. If you get hyper during your treatment and your fT3 will be at the top of the range, you are pooling and fT3 cant get into your cells cause low/high cortisol.
According to your results you should implement hydrocortizone/Adrenal cortex or adaptogens.
I will try it first because I dont want to jump into TRT because I have a feeling that it would impact me the same as you. If you have done all the steps, Iam sorry that I wrote that again.

Anyways best of luck!

Propranolol for blasts? You’d want a cardioselective beta blocker to counteract AAS induced autonomic dysfunction. BB’s that block both b1 and b2 adrenergic receptors will work, but they have the additive effect of (sometimes) reduced exercise tolerance

Do they help with anxiety?

Less so than 1st gen beta blockers… but yes, it’ll still reduce the increased cardiac output associated with anxiety.

It should be noted beta blockage won’t reduce (at least directly) the psychological manifestations of anxiety. There are two types fo symptomatology regarding anxiety, physical and psychological.

Physical confines to say… a racing heart rate, increased respiratory rate, perspiration etc. Psychological pertains to racing thoughts, tunnel vision, fainting etc. By blocking the effects of catecholamines at receptor binding sites we eliminate the physical side effects (some or all depending on the type of beta blocker used), this can be good to lessen psychological sides in some cases (though not all), as the two typically go hand in hand, feeding one another like a viscious loop.

If you’re looking for serious reduction in psychological side effects of anxiety, you’re going to want to use something that impacts neurotransmission, cognitive behavioural therapy or both. Benzodiazepines are an absolute last resort (unless you get a script for very acute, short term use to help you through a hurdle… say four or five days of diazepam won’t kill you)… or a script for a singular Xanax at the hand for occasional emergency panic attacks, this kind of use is appropriate (provided other measures have been tried but have failed… or the panic attacks are so severe you literally can’t move/ are passing out and whatnot). but to be put on full time (as is unfortunately the case for many) is just (most of the time) irresponsible practitioning within the prescribers side.

I do all of that, my anxiety was pretty under control prior to trt. Trt is somehow negating my ssri or something.

Then perhaps it is excessive sympathetic nervous system stimulus, in which case

  • blasting is a terrible idea for you until you have this under control (like I do… I have autonomic dysfunction)… (some compounds will be exponentially worse than others… for instance I’ve found drostanone to anecdotally induce less autonomic dysfunction, however this will differ from person to person)

  • beta blockers will probs help

I was on 35-70mg mast a week but jesus I’ve never shed so much in my life. Didn’t help much with anxiety, libido was amazing though.

Just upset man, I’ve put a lot into trt in hopes of being able to benefit my mental health, libido, and counter act my fatigue.

I’ll try and get a selective bb but will see… The meds I plan to try eventually to help with my issues, topimat(idk how its spelled), verapamil, or some bb’s. The neuro may even suggest keppra, depending on his knowledge… Currently on a sodium channel blocker in attempts to lower neuron voltage that causes overstim + lowers glutamate.

That’s genetic, I don’t shed on anything… it’s unfortunate, but if you wish to use AAS you can either take a risk with minimally androgenic compounds or simply use the norm and know for certain you’ll go bald

Either way there’s a decent chance of premature balding

Idm balding eventually but I like my hair rn, and the amount I shed with 3 weeks of mast was insane.

I’m curious if you Have considered looking at the mentality rather than the physical causes.

Anxiety for me is highlighted when I am stressed and worry worry about everything. I started praying, meditAting, helping others and I rwsplfe my issues without medicine.

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Yeah, I do mindful meditation everyday 2x for 20 mins. Also am well versed in cbt… My issues seem to stem from the neurological/Partially psychosocial

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Well it’s just stupid at this point… Been a couple months now and the only way I can explain how trt is affecting me is its put me in a constant state of hyper vigilance.
I am not panicing but it is bringing out my inner ptsd, which I guess I could say I’m suffering from, it’s legit just intensified my ptsd and ocd over this shit, I spent the last 2 months obsessively researching the effects of t and e2 on neurotransmitters and the brain overall and its ridiculous that I can’t find many informative articles.

I have not touched my protocol since and even had to switch ssris from the paxil I was on for 10 years to now zoloft due to the fact that I made the assumption that my ssri pooped out. How come nobody explained its effects on the amygdala and hypothalamus? It clearly accelerates whatever neurons are already firing and makes them fire 2x as hard. My amygdala is constantly scanning for threats everywhere I go its terrible.

I’m not even logically scared of anything I just sit around and feel like I’m in danger for no reason, even in the gym, even at work I’m just on edge, irritated at all times for no reason. Then when I get home I obsessively research why I feel this way.

My only solution/ theory at this point is up my zoloft like crazy, only on on 50mg rn, or quit t. I don’t wanna quit t so…

First official panic attack in 10 years, started to just feel really out of place and disassociate. Heart started beating uncontrollably which scared the shit out of me because I’ve had increases in heart rate many times but nothing this intense in years. I could barely make it home I kept going in and out of dpdr and just couldn’t think straight, I got in my car and started driving home and just could not calm down and even dialed 911 but hung up. Got home and immediately got better when I got inside… I’ve had panic episodes on and off through the years, but this was a full on full throttle like 180+ bpm panic attack.

Before and after I was 100% completely calm in my mind, minus the fact that I’ve been irritiable and on edge and in a “ready to fight” state all day. Before trt I was 100% calm, emotionally flat etc and I was hoping trt would give me some emotion, but not this on edge bs, its like its simply keeping me in the fight from.the fight or flight instead of flight which is my natural instinct.

I’m really bummed and just assuming my hpa axis and hypothalamus, amygdala and limbic system as just completely messed up. No one seems to be able to explain the affects of high t on someone whos anxiety prone, and perhaps why I’m completely malfunctioning? Does it lower serotonin or what? Its proven to raise gaba, but my limbic system is just completely malfunctioning and sending panic singals even when I’m calm, I’m not trying to fight I don’t need the god damn adrenaline spike

when I got home and calmed down my bp was 119/69 heart rate 106, bp is always good, I will donate soon but doubt its a hhh thing

If anyone can explain why im always on edge irritable and in a fight state 24/7 I would appreciate, my conclusion of why my body paniced was My body assumed I was about to be in a fight due to fight state all day and I just happened to be in the gym going ham and my body assumed there was danger since I was being really aggressive and just sent me a shit ton of adrenaline

Your body was low t and you got used to being in that state. Now you are having healthy levels of T. You need to go see a professional and work on this mentality. You are literally freaking out over having energy and focus. I mean this is what we want and it sounds like you simply don’t know how to operate while having a hormonal optimal body.

The ssris don’t help. You can try daily and also check thyroid. Some have weird mental health issues when thyroids low.

Otherwise I won’t point the finger at TRT. If I was you I would tell myself I am now having hormones and my body needs time to adapt. Am I over thinking it .

What do you do for this? Meditate? Lifting weights , eating right and positive thinking?

Sorry you said you do above. Not sure what to tell you.

Tell me the dose and results from labs or share labs. CurioUs where your hormones are.

@jpt365 not sure if you can help this guy or not; but I figured i would CC you. Maybe some cream would help this guy.

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I have t cream, thing is I am stubborn and need to know why its doing this, so I can trouble shoot it. If its causing low serotonin I’ll get a 5ht agonist and increase my ssri, I’m too stubborn to quit trt injections.

I wish someone knew enough in regards to its affects on the nueorobiological side, I’ve watched ucfreak on youtube he actually goes pretty in depth on the effects of AAS on the brain and it all actually makes sense he just nevers links the research articles. All the studies are on large aas doses and not trt doses

Having an anxiety disorder can make TRT a tricky thing.

If you really need TRT is difficult to judge, but i certainly wouldnt recommend TRT for the purpose of counteracting the symptoms cause by the anxiety medication.

Regardless of TRT or not, it might be worth to invest time and money and focus on treating the mental aspect of the anxiety disorder. There are different forms of therapy available, but I can highly recommend systemic psychotherapy as it deals with patterns and dynamics of human interactions and therefore directly adresses the social anxiety aspect.

Regarding TRT; if you want to stay on it reduce your dose of T enant or cyp to the initial dose of 50 e4d or better to 20 or 25 eod to reduce variability. Your T was definitly high enough on that dose. The higher dose of T and the other stuff (stop this) gives you too much of stimulation obviously.

I definitely already have been investing in my mental health, I do agree and have no longer looked at trt to counteract my mental health as during my research its become clear that hormones simply amplify neurotransmission.

I will obviously begin lowering my dosage. But even then the stimulation sometimes is too great.

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I’ve notice frequent small shots seem to work better for those prone to anxiety.