I got this idea from a guy much stronger and bigger than me and I have to say I like it a lot. This guys trains like a psycho, he hits every bodypart once per week and DESTROYS it. High reps, low reps, supersets, rest pause, dropsets, forced reps, and every intensity technique known to man, mixing up basic compound movements and isolation exercises.
As you can surely imagine, this type of training is rather taxing on the CNS. So instead of taking a week off once in while, he does a week of machine training and isolation exercises, moderate to high reps, mostly to failure, still hitting every bodypart once per week.
The reason for this is that the CNS can recover because you isolate the muscles by avoiding big compound movements, but you can still train them for hypertrophy, so you can leap at least some benefit from your “off” week. I have never heard of this before, and I’d love to hear your opinions on this.
Remember this guy has the work capacity of a mutant, but I think this would work pretty well for intermediate/advanced level lifters.