I’ve always wondered this. I don’t take it currently (or anymore). Not considering it either, if my E2 “feels” too high I just ride it out until it normalizes.
Is it like various other drugs that have a rebound effect that makes it almost risky to start because stopping will suck so much? In other words, like taking a single dose of adderall because you’re a little tired - knowing you’ll pay for it all day tomorrow?
For me the E2 rebound effect was very bad, once the AI detracts from the aromatase enzymes there is a huge spikes in E2 levels and feels like I’m having a heart attack, at this point estrogen is higher than it was before you took the AI however briefly.
Wow that’s wild. With that I’m surprised more doctors don’t go to aromasin instead.
Of those I know personally who discontinued anastrozole, I have not heard of this. I know a few who take anastrozole, 1mg, on an as needed basis. They may take one every three or four weeks.
When I stopped it, I felt nothing negative, E2 went from 23 to 55. Gradually, my joints felt better and total cholesterol dropped from 205 to 171.
Like @highpull said, I felt nothing and only gradually better. Never anything negative.
Never knew it affected cholesterol too!
Estrogen is cardioprotective. Women do not have heart attacks like men. Once they hit menopause they start to catch up.
Aromasin is gentler because it kills off the aromatase enzymes and therefore there is no E2 rebound. We’ve had some members unable to create new aromatase enzymes who were never on an AI.
Just saying be careful. I’ll take daily injections over AI usage, no risks.
I have heard of people (on other boards too) having long term low E2 from an AI.
TBH the first serious and drawn out depression of my life began after I tried aromasin a year and a half ago. I’ll never know if there was a connection but it sure was ironic.