I recently went to five different doctors to see if I can get a prescription to estradiol valerate (T:E ratio low), and I have been dealing with typical low libido and poor EQ. All five doctors, including my urologist, admitted that they had never prescribed estradiol to resolve symptoms. However, anecdotally, some men have had success with this. Why am I sharing this? I am sharing this because my doctor and other doctors rely solely on labs to determine if a person has resolved their symptoms, and that is not the most effective way to go about things.