[quote]vexeN wrote:
Cool question, one I’ve often wondered as well. I remember reading a study where they injected a tendon with nandrolone decanoate and exercised it through various ranges of motion using various stresses. I’ll see if I can dig it up somewhere. The result was a smaller stronger tendon, seeing as collagen shrinks as it matures, makes sense.
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If they injected nandrolone decanoate into the tendon, it would be some kind of prolotherapy, thereby making it hard to determine how much the injectant might have contributed to the result of a smaller stronger tendon - unless they had a control group that received dry needling.
[quote]vexeN wrote:
What FattyFat said is interesting, if the mechanism that reduces pain is simply from the anti-inflammatory effect provided by the decanoate ester, then I’m wondering in what way it would decrease collagen cross linking integrity? Not a challenge to the statement, I’m literally curious.
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I wasn’t precise enough in my above post regarding nandrolone. The studies I’ve read about nandrolone making ligaments and tendons thicker, but weaker (reduced collagen cross-linking integrity) referred to systemic use, not to direct application into incompetent connective tissue.
[quote]vexeN wrote:
Anyway if the ester is the culprit, shouldn’t testosterone decanoate provide the same effect? Also people using oral prohormones like M4OHN which is a derivitive of nandrolone, report joint pain reducing effects as well. So maybe nandrolone has a role to play?
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Sorry, can’t really comment on this one.
There is a study where testosterone (don’t know what ester) was used as proliferant during prolotherapy, with promising results.
[quote]vexeN wrote:
Cool stuff anyway. Also to the OP what FattyFat said about acute injury is basically it. The old RICE theory is the most retarded thing ever conceived. Acute inflammation is the body trying to heal itself, inflammation is still involved in chronic injuries, but not to the extent that anything can actually regenerate anymore, hence why it’s mostly only functional movement that causes pain once injuries become chronic, at rest you’re usually fine or not so bad, becuase of its orthopedic nature. Anyway, there are various growth factors, macrophagues, etc, involved in the process, I might type some of that out later.
You might want to look into prolotherapy, or regenerative injection therapy as well (same thing). It works by inducing microdamage into an injured ligament/tendon/joint capsule, etc, drawing growth factors to the area and initiating repair. Pretty effective in my experience. Got an ass load of studies on different subjects using various proliferants and growth factors to repair various grades of tears, and cartilage damage. Saved me anyway. Most orthopedic issues are poorly understood, in fact most general practitoners have to google their anatomy nowadays.
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I’ve had good results with prolotherapy.
Still, healing doesn’t happen overnight with this treatment modality and it’s important to strike just the right balance between nutrition, training and recuperation to make this work.
Prolotherapied connective tissue needs to receive just the right amount of pull, applied from suitable angles, to help with collagen formation.