I have read of studies where Pge2 raises Cyclic AMP concentrations. I know that Pge2 is supposed to be the pro inflammatory prostagladin but isnt it true that asthma sufferers such as myself have a lack of cyclic AMP in the lungs? I also know that fish oil is reccomended for asthma but if im not mistaken doesnt fishoil block the production of pge2 to some extent. I know it reduces inflammation ofr what not but the info i have been gettin has seemed contradictory. Any one have any clarity or suggestions.
I guess nobody knows what im talkin about???
Some of us understand what you’re saying, we just don’t know the answer. I know that generally fish oils reduce the immune response - so they’re useful when your body is working against you (ie. training). I’m not very knowledgable on the mechanisms of training.
cAMP is a wonderfully complex trigger. Sometimes it seems cAMP is doing everything in the cell - it cascades onto so many pathways. My only suggestion is to look at medline abstracts and just read them - you’ll eventually get a “feel” for what you want to know.
Eddie, El_Machinae is right. The topic is just a little bit beyond the scope (and possibly interest) of this forum. It’s a bit of a stretch for me, but I’ll take a stab at it anyway.
Based on some of my resources, asthmatics should consider taking the drug Hydergine to safely boost intracellular levels of cAMP. You would need to test for it, but ideally you would want to increase the cAMP:cGMP ratio in favor of cAMP. Higher levels of cAMP often reduce bronchial constriction. The recommended dose of Hydergine is 5 to 10 mg a day with food. The FDA-approved drug Theophylline is used to treat asthma because it boosts cAMP levels. Coleus Forskohlii (an herb) is also supposed to increase levels of cAMP, but in your case, I would only use a medicinal quality – i.e., a standardized extract – the type you might get from an ND, a DO, an orthomolecularly inclined nutritionist or the like.
Now, the one point I would like to make is that cAMP and cGMP are both intracellular messengers. Prostaglandins, however, are hormone-like substances found in cellular membranes that can be significantly influenced by dietary factors, specifically the intake/ratio of Omega-3 to Omega-6 fatty acids. The Prostaglandin-2 series is, as you stated, inflammatory, with the Series 1 and 3 being ANTI-inflammatory. Series 1 and 3 are good (derived from the intake of Omega 3s) and Series 2 is bad (derived from the intake of Omega 6s and animals that eat corn).
So if you’re following me, Arachidonic Acid is incorporated into cellular membranes by eating animals that have eaten corn (pigs, chicken, cows) and/or by eating a disproportionately high percentage of Omega-6 fatty acids (found in safflower, sunflower, sesame, peanut and corn oil). ALL – I repeat “ALL” – of the Series 2 prostaglandins are created from Arachidonic Acid. And yes, fish oil (because it is extremly high in Omega-3 fatty acids is effective in treating asthma because it displaces Arachadonic Acid (metabolized from Omega 6 fatty acids) in the cellular membrane. It could take 3 months to a year to displace current fat and phosphlipid stores of Arachidonic Acid.
So my belief is that you’re close, but that prostaglandins and cAMP are only loosely related, not causally related.
There are two avenues of research I would recommend to you, if you’re looking for relief with your asthma. One, check into Traditional Chinese Medicine. TCM has had great success in treating asthma. Two, check into the Life Extension Foundation’s protocol for asthma. Most asthmatics are not aware of the many published studies showing that high-potency vitamin supplements induce a reduction in the incidence and severity of asthmatic attacks; things like magnesium, N-acetyl cysteine, Vitamin C, DMG before vigorous activity, B6, B12 and citrus bioflavonoids. The list/protocol goes on, but you can do a search and more research on asthma @ www.lef.org.
Good luck to you, Eddie!!!