[quote]Slay the Dragon wrote:
I noticed the main types of pain mentioned were related to inflamation, how would this supplement aid someone with a herniated disk? Would there be a noticeable difference?[/quote]
STD,
Curcumin 500 is often used as a substitute for NSAIDs, but it depends on the nature of the disk herniation. One thing is for sure, it can’t hurt.
TZ
[quote]progwizard wrote:
I have been using curcumin from NOW Foods and Doctor’s Best from a few months now. I just stick to one capsule daily to prolong the bottle.
Any particular reason why piperine was chosen over bioperine in this formula?[/quote]
PW,
Piperine is the main alkaloid of black pepper. Bioperine is simply a standardized form of piperine.
TZ
[quote]Lonnie123 wrote:
How would this work for something like DOMS? I’m not a huge supp junkie, but it this could even get rid of 50% of my leg related DOMS I would be in for life.[/quote]
Lonnie123,
I’m not a betting guy, but if it’s truly classic “DOMS” that you suffer from, then I’ll eat my shirt if Curcumin 500 (at 4 caps/day) doesn’t help.
TZ
[quote]MIKMATT wrote:
In terms of anti inflammatory effects there are two other powerhouses for you inflamed athletes to look at, Astaxanthin and green lipped mussel oil. both are extremely potent and have lots of research to back them up. Also they are both very good for you in many other regards.
And thats my 5 cents worth!![/quote]
Agreed!
TZ
[quote]Tim Ziegenfuss wrote:
Cockney Blue wrote:
how would piperine affect the Beta Alenine I am taking?
Can I take an NSAID while I am taking this if my pain is really intense?
CB,
Piperine and beta alanine - not sure. Last I checked, there were two mechanisms behind the ability of piperine to increase in vivo bioavailablity: 1) non-specific (e.g. increased blood flow to the GI tract, decreased HCl secretion, increased enzyme levels that influence active and passive transport of nutrients to the intestinal cells); and 2) non-specific (e.g. inhibition of enzymes that break down drugs/nutraceuticals).
I’ve never read any research on the effects of piperine on amino acid absorption, so that leaves beta alanine as a question mark for now. If you do try the two together, keep track of the “tingles” you get…it may provide some insight.
As far as co-administering a NSAID, check with your doc.
TZ [/quote]
Thanks for the response Tim however the check with your doc line doesn’t help much here in Mexico. Doctors here tend to tell you what they think you want to hear then suggest expensive surgery.
[quote]Reg Dunlop wrote:
Alwyn Cosgrove wrote:
When you start looking at a combination of:
Rez-V
Flameout
Superfood
And Curcumin – it’s an EXTREMELY solid little “health insurance” stack for around $3-4 per day.
–
AC
This powerhouse group of supplements is clearly a great insurance policy, but for those with an imbalance between Th1 and Th2 immune response that shifts toward the Th2 side, would all of these taken together have the potential to exacerbate certain systemic autoimmune disorders that exhibit a Th2 dominance?
I ask this because autoimmune issues run in my family, and I don’t want to inadvertently worsen any issues by using a group of products that are absolute gold for most folks without autoimmune issues.[/quote]
Dunlop,
Great question…and one that I am not qualified to answer. Check with a good naturopath or an enlightened MD. Hector Lopez (out of NJ) is my top recommendation.
TZ
[quote]lifter85 wrote:
Quick question…my girlfriend tends to wake up not quite a bit but more than a regular person with headaches. Would this help her headaches somewhat? I noticed someone earlier asking, but never saw a response to it. If so I’d buy some for her and myself for lifting.
As well, do you think that little insurance health stack (Rez-V, Superfood, Flameout, Curcumin 500) would alleviate any of her headache symptoms? I’m sold already myself on Superfood/Flameout, never go a day w/ out a full dosage or more, but just checking to see if it’d benefit her in that way. Might be a good b-day present stack; then again she might just kill me, heh.[/quote]
L85,
Headaches can be a bugger to figure out. It could be weather/allergy related, a micronutrient deficiency, stress, etc. I used to get 2-3 headaches a year. Then I moved 30 miles South and now I get headaches all the time, especially during the Spring and Summer. That said, whether your stack helps her headaches or not, she’s better off health wise taking Flameout and Curcumin 500.
TZ
[quote]Johny23 wrote:
I don’t like to mention this (because I really like T-Nation), but WHY are you releasing this, when Anaconda is complete and been advertised for such a long time? You haven’t mentioned this supplement before and yet release it before Anaconda. Maybe it’s just marketing tactics, but I don’t like it. This supplement now looks like a filler compared to Anaconda.[/quote]
Curcumin 500 was released because it’s something much of our staff have been using for some time and we believe it will be a benefit to Testosterone Nation readers.
While select coaches and athletes have been using Anaconda, it is not yet available in the quantity required for release to our members.
[quote]RonC wrote:
Can this prodcut be taken with cissus quadrangularis?[/quote]
RonC,
With the caveat that everyone is different and adjust your dosages carefully, there are no medical reasons I know of why you cant take CQ and Curcumin 500 together.
TZ
P.S. I’m not a “real doc” (PhD not MD), so when in doubt always check with your PCP.
[quote]Just_Jamie wrote:
Sorry if the question has already been asked, but are we looking at this as a replacement for aspirin? For example, do I take it if I have a headache or just when I’m sore? Thank you![/quote]
JJ,
Depending on the cause of the headache, in many cases Curcumin 500 should help reduce pain. It really shines for muscle and joint pain though.
TZ
Will this help alleviate muscle soreness from training?
[quote]Tim Ziegenfuss wrote:
Jason Randall wrote:
Fellas - due to my schedule I keep pretty quiet on the boards, but have to add in my appreciation on this one. This looks outstanding, and once again Biotest has created a product that speaks to a real need. As I’ve gotten older (37 now) inflammation and chronic use injuries are a real concern. It’s bizarre to remember the days when I looked at the ‘over 35 lifter’ forum and thought that that was light years away.
Just to clarify a couple of thoughts:
1 - The MOA (mechanism of action) is nearly identical to the prescription Cox II’s? (again, obviously the nasty side effects are negated)
2 - Clearly this should work wonders as a synergistic agent with Flameout, which bleeds into my other question - due to the health benefits of Circumin, is it appropriate to take daily, or should it only be taken for acute bouts of pain? Those with Chronic pain should be very thankful for this supplement.
Thanks again for a rock solid supplement - I would also think that this is a natural fit for anyone engaging in an intensity phase, as it should greatly assist with recovery, especially when combined with the existing Biotest Supplement Protocols.
JR,
To answer your Q’s:
The most recent review on turmeric, in the January issue of the Journal of Clinical Immunology (5), states: â??Traditionally known for its an anti-inflammatory effects, curcumin has been shown in the last two decades to be a potent immunomodulatory agent that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells. Curcumin can also downregulate the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12, and chemokines, most likely through inactivation of the transcription factor NF-kappaB. Interestingly, however, curcumin at low doses can also enhance antibody responses. This suggests that curcuminâ??s reported beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease, Alzheimerâ??s disease, diabetes, and cancer might be due in part to its ability to modulate the immune system. Together, these findings warrant further consideration of curcumin as a therapy for immune disorders.â??
Hope that helps.
Hey Tim - as always, you’re the man. Thanks for the clinical info, it’s greatly appreciated. The more research I read on this compound, the more compelling it becomes.
Thanks again!
This is pretty sweet. I just did some research and reference checks. I’m impressed.
Nice job, Biotest. I’ll pick up a couple of these.
[quote]Tim Ziegenfuss wrote:
Lonnie123 wrote:
How would this work for something like DOMS? I’m not a huge supp junkie, but it this could even get rid of 50% of my leg related DOMS I would be in for life.
Lonnie123,
I’m not a betting guy, but if it’s truly classic “DOMS” that you suffer from, then I’ll eat my shirt if Curcumin 500 (at 4 caps/day) doesn’t help.
TZ[/quote]
It is very classic. Consistently appears starting latehe next day and is really in full swing on days 2-3… Honestly makes it hard to walk “normal” for 2 days sometimes, and getting up from a chair is a painful task. It happens across my whole body, but I can deal with the triceps soreness.
If this can put a damper on my back and leg soreness, Hell, I just might eat your shirt. I’ll give it a go for a month and see how it works.
As much as you seem to be lovng flaming my post, it irritates the hell out of me that the medical profession in general looks down on nutraceuticals as lesser products than a new chemical entity that has been through all 3 trial phases for its marketing authorisation.
The use of clinical claims on food products is now regulated by the European Medicines Agency and each member states legislation, its one reason that certain yoghurt manufacturing companies are spending huge amounts of Euro’s on performing clinical trials to back up their claims on their products.
The supplement industry suffers even more as the general masses of medical professionals who do not do their reading on the background, such is cited on the Biotest product pages.
One way round this is to work to a markeing authorisation - which is expensive, hence my acknowlegment of the commercial considerations that apply.
http://www.emea.europa.eu/htms/human/hmpc/index.htm
http://www.foodnavigator.com/Legislation/EU-food-companies-scramble-to-submit-health-claims
(the second is a laymans article)
So yes, I am serious. No it is not a joke.
[quote]redgladiator wrote:
trnielsen wrote:
bluebear wrote:
Biotest guys,
I appreciate you wish to market this as a supplement, but you’re skating very close to making clinical claims which I assume you know now require a clinical trial to substantiate.
If you’re interested I can put you in touch with some decent CRO’s who could manage this for you - just PM me. There is obviously a cost to bring a drug to market but if this is really that good then the commercial considerations should outweigh the development costs.
Is this a joke?
What makes this hilarious is not that bluebear was joking but that bluebear appears to be 100% serious.[/quote]
Just to add to the clinical info, I found this phase I trial that’s probably still ongoing on the FDA’s trial register
It’ll be interesting to see where the data fro the trial takes this, the lab work in immunology was obviously good.
I found this article for people interested in piperine interactions of different drugs.
I’ve heard a lot of great things about curcumin, but it was always for its anti-cancer properties, or to fight memory loss issues due to aging. I’d never heard of it for pain relief. So that’s a nice bonus. I was looking for ways to add curcumin in my diet - and in my parents’ diet - so that should make it easier 
I have a psoas injury that’s been bugging me for a while so I hope this can help.
Just got my order in from FEDEX a few minutes ago. I’m going to pop a couple of Spike and some Surge and drop the hammer on a high volume, total body session this afternoon with some superset legs - a one off workout/test drive if you will - and see how this stuff works.
I’ve had to really lay off over the last few weeks to due to severe elbow/knee tendinitis, and am just now starting to feel refreshed, so I’m looking forward to seeing what this can do from a DOMS perspective, as well as in addressing Tendinitis, which we know is largely driven by inflammation.
I’m a bit torn, considering either taking it proactively an hour or so post workout…or just waiting for the soreness to set in, THEN take it, and see how it affects the pain thresholds…second thought, I think I’ll just punish myself and take it post workout…the prework out stack should give me plenty of extra juice in driving myself into a hole.
I’m due to have both knees cleaned out this summer (arthroscopically) and think that this product will be a Godsend for that as well…
[quote]progwizard wrote:
I found this article for people interested in piperine interactions of different drugs.
http://www.delano.com/Articles/piperine-multiplies.html[/quote]
–
Interesting find progwizard - thanks for the info.
It appears that the half-life is reasonable, as is the peak plasma data, so not much to worry about at all considering the risk/rewards outside of a few hours. - really no risk overall…though if you’re giving it to anyone that takes bloodthinners/rifampin/viagra, I’d give them a heads up and avoid concurrent dosing…unless you cut the viagra does in half.
I would also point out that if one is really ill and is on an antibiotic, this will inhibit the bioavailability of the drug. Though that is an issue with MANY other compounds aside from piperine - I just know from experience (I worked in the Anti-Infective marketplace for a few years) that when people are sick, they’ll often take an analgesic with their Anti-Biotic - so don’t take it with is…
The link that Progwizard posted is worth a quick read…