Regarding saturated fats, obviously large amounts are bad due to the effect on metabolism. But your body uses carbon chains like palmitic acid (C16) for multiple functions, so it’s not like you don’t need some.
In fact, protein palmitoylation is a dynamic process that serves to anchor proteins to the inside of membranes as a cell requires their activity there. This is especially important for the neuron where (some) proteins are anchored and un-anchored at the synaptic junction as their activity is needed. There was a paper in Nature 1.5 years ago describing the process nicely. It happens quite a lot and virtually all stimulus induce changes in the membrane proteome that is controlled by lipid (C16) localization. But it is hard to say what kind of turnover each individual lipid chain goes through, if it is degraded each time it is used or not.
It certainly is no reason to start supplementing saturated fats though.
Whether fat deficiency could start to hamper these process is an interesting question, but probably only accessible through extreme cases of malnourishment.
got my package today, took way too long to get here, but all the contents arrived safely. Nothing was taken. Kind of wish i had ordered ani rather then oxi though after more consideration and research though…oh well.
I don’t know if this has been brought up already, but Ive read quite a bit of each of the threads and looked up Vinpocetine, Huperzine A and Modafinil and they all seem to have some pretty serious sounding side effects.
Modafinil can cause life threatening rashes, hallucinations and cause one to develop suicidal thoughts. Vinpo reduces immune function and Huperzine A causes tightness in the throat and/or chest, chest pains, and hives and rashes.
I don’t know how true these all are, or how common they are, but are these issues a concern to any of you guys using them?
I’ve been diagnosed with ADHD and am currently using Adderall. I guess what Im asking is are these side effects likely and as severe as they sound, and are there any brain boosters out there with absolutely no history of side effects?
[quote]Muscles297 wrote:
I don’t know if this has been brought up already, but Ive read quite a bit of each of the threads and looked up Vinpocetine, Huperzine A and Modafinil and they all seem to have some pretty serious sounding side effects.
Modafinil can cause life threatening rashes, hallucinations and cause one to develop suicidal thoughts. Vinpo reduces immune function and Huperzine A causes tightness in the throat and/or chest, chest pains, and hives and rashes.
I don’t know how true these all are, or how common they are, but are these issues a concern to any of you guys using them?
I’ve been diagnosed with ADHD and am currently using Adderall. I guess what Im asking is are these side effects likely and as severe as they sound, and are there any brain boosters out there with absolutely no history of side effects? [/quote]
Shit man, Aspirin kills people. If you get those side effects then don’t take it. If you don’t, then rock on. Everybody’s got different physiology going on.
[quote]Muscles297 wrote:
I don’t know if this has been brought up already, but Ive read quite a bit of each of the threads and looked up Vinpocetine, Huperzine A and Modafinil and they all seem to have some pretty serious sounding side effects.
Modafinil can cause life threatening rashes, hallucinations and cause one to develop suicidal thoughts. Vinpo reduces immune function and Huperzine A causes tightness in the throat and/or chest, chest pains, and hives and rashes.
I don’t know how true these all are, or how common they are, but are these issues a concern to any of you guys using them?
I’ve been diagnosed with ADHD and am currently using Adderall. I guess what Im asking is are these side effects likely and as severe as they sound, and are there any brain boosters out there with absolutely no history of side effects? [/quote]
I can pretty much say with the utmost confidence that nootropic agents such as fish oil, choline and vinpocetine are much, much safer short or long term than low dose amphetamines such as adderall.
I’ve been experimenting with various nootropics over the last 6 months. I have tried:
Bacopa
Huperzine A
Piracetam
Aniracetam
Oxiracetam
*I take omega 3, vitamin B, DMAE and Vinpocetine on a daily basis.
Oddly enough, Huperzine A was the only one with a noticable effect. Piracetam did make lights more glowy and my hearing more sensitive, but no noticable cognitive effects on memory retention or improvement on test scores. Oxiracetam was always a hit or miss, I got the laser pin point focus effect once (out of about 20 times) with a dose of 440, but I have no luck replicating that experience.
My questions are:
How should I cycle huperzine A?
How / what dose do you use for oxi? I’ve tried highly doses, but it just totally knocked me out and I fell asleep 10 minutes into a lecture LOL
Are there any none aniracetam responders out there too?
I’ve been taking my DMAE, Piracetam, PowerDrive and just pre-mix all jugs into one large jug. I figure out how many doses of each to add - Usually 1g of DMAE and one serving of PD for every 5g Pira in the bottle.
For example, I have a 100g bottle of Pira, I’ll toss 20 servings of PD and 20g of DMAE - I’ve been using an empty protein powder container.
I use a 5g scoop and use about 2-3 of them. I toss that all into my green tea in the morning and go.
Huperzine A has buildup effects in the body - and it is transient. So using short cycling schemes is not of use here - you want to cycle it like 4 weeks on/off minimum, perhaps longer.
Also note that Hup is a somatostatin inhibitor - so it might be of use to take at night to inhibit somatostatin and in turn boost GHRH.
Not sure about doses, but Oxi isn’t for performance nor should it be taken before class - this was went over numerous times in the original thread which i suspect you need to go over again. BBB noted many times oxi was for study only, at home - and then to expect to need a nap or rest afterwards.
Probably quite a few. Were you taking a choline source of at least a gram w/ it?
Is any way of increasing acetylcholine levels better than another?
(Correct me if I’m wrong, spreading false “information” is a serious offense in my book)
Do all these roads lead to Rome? Alpha-GPC seems to be the fastest, but could we get away with consuming more of less powerful/expensive compunds earlier/always and get similar results?
Any reason to use several sources? Which yields the best result/price score?
Huperzine A has buildup effects in the body - and it is transient. So using short cycling schemes is not of use here - you want to cycle it like 4 weeks on/off minimum, perhaps longer.
Also note that Hup is a somatostatin inhibitor - so it might be of use to take at night to inhibit somatostatin and in turn boost GHRH.
Not sure about doses, but Oxi isn’t for performance nor should it be taken before class - this was went over numerous times in the original thread which i suspect you need to go over again. BBB noted many times oxi was for study only, at home - and then to expect to need a nap or rest afterwards.
Probably quite a few. Were you taking a choline source of at least a gram w/ it? [/quote]
Thank you for the info.
I’ve read through the thread and if I recall correctly oxiracetam is more of a memorization aid, so I mixed it into a bottle, and sipped it through out my very detailed nutrition class (even minute details like slentrol is an obesity drug for dogs is tested).
Right now I’m taking one pill of DMAE (.405g), I’ll try and see how 2 pills a day goes. My current huperzine A cap is 200mcg, would it be better to open the capsule and mix it into water and sip it throughout the day? Or is it more of a one time dose?
Huperzine A has buildup effects in the body - and it is transient. So using short cycling schemes is not of use here - you want to cycle it like 4 weeks on/off minimum, perhaps longer.
Also note that Hup is a somatostatin inhibitor - so it might be of use to take at night to inhibit somatostatin and in turn boost GHRH.
Not sure about doses, but Oxi isn’t for performance nor should it be taken before class - this was went over numerous times in the original thread which i suspect you need to go over again. BBB noted many times oxi was for study only, at home - and then to expect to need a nap or rest afterwards.
Probably quite a few. Were you taking a choline source of at least a gram w/ it? [/quote]
Thank you for the info.
I’ve read through the thread and if I recall correctly oxiracetam is more of a memorization aid, so I mixed it into a bottle, and sipped it through out my very detailed nutrition class (even minute details like slentrol is an obesity drug for dogs is tested).
Right now I’m taking one pill of DMAE (.405g), I’ll try and see how 2 pills a day goes. My current huperzine A cap is 200mcg, would it be better to open the capsule and mix it into water and sip it throughout the day? Or is it more of a one time dose?
–Mond
[/quote]
I use at least a full gram of DMAE every time - sometimes 2g.
I’m not a fan of Hup really. I say use out what you have at 200mcg a day, then switch over to something else. Really, as far as herbs go, Vinpo is better and safer
I bought Jarrow Formulas’ Vinpocetrine 5 mg, took one serving with food (5 mg), nothing. Today I decided to try 10 mg, took 2 servings (10 mg), maybe 10 minutes later felt some pressure in the upper head, but I cannot say I feel any other effects. Should I get a different brand, take a higher dose (maybe twice a day?), or change my expectations? How Vinpocetrine supposed to work?
P.S. Does lemon balm make one sleepy? Can you really feel its effects?
Just wanted to say that I’ve been following these threads and there is an amazing amount of information here. Well done, and thanks for sharing-it’s been an interesting read.
And I just saw this article over at Cracked, so I thought I’d link it for your amusement.
“grapefruit juice is a selec-
tive intestinal CYP3A4 inhibitor. The overall exposure of
some drugs can be increased by more than fivefold when
taken with grapefruit juice and increase the risk of adverse
effects”
not totally sure the impact of this, anyone want to take a crack?
[quote]middleageguy wrote:
Yes, the right dose of lemon balm can make you sleepy…a smaller dose can have an anti anxiety effect. Experiment because everyone is different.[/quote]
Any recommendations for the brand? Also, is it better to take it in a liquid form or in a pill?