CILTEP (Nootropic Concept)

Diet and Nutrition
1

I’m wondering if anyone has experiences with CILTEP, which stands for chemically induced long-term potentiation. I know many of us have taken or currently take Brain Candy, and have dabbled in other nootropics (racetams, modafinil, vinpo, other herbs), but the concept of CILTEP seems to be relatively new. The idea is to increase cAMP by the use of forskolin, inhibiting PDE4 through artichoke extract, and dopamine support via a precursor (PEA, tyrosine, etc) as more cAMP is supposed to increase the rate of dopamine synthesis. You can google for a hell of a lot more info.

I was considering trying CILTEP in conjunction with Brain Candy. Brain Candy would cover the the dopamine support (n-acetyl-l-tyrosine), as well as all the other goodies which are reported to work well with CILTEP (ALCAR, cdp-choline, caffeine/theanine).

My forskolin source would be Carbolin 19, although I am unsure if this is too much forskolin for what people normally recommend using CILTEP (4 mg of 20% forskolin, Carbolin 19-19 has 20 mg forskolin in one pill which may be too much). For artichoke extract, I would just use some other generic source for that.

2

This could be exciting.

3

[quote]rrjc5488 wrote:
This could be exciting.[/quote]
Guess not lol

4

started out the stack today, if anything noticeable happens in the next couple of weeks I’ll update the thread

Forskolin 10 mg
Artichoke 1 g
Brain Candy

and other misc support supplements

5

hows this going?

6

[quote]mattwalshonline wrote:
hows this going?
[/quote]
I had to stop it! When I was doing it I was sleeping RIDICULOUSLY long… like, I need at least 11 hrs of sleep to feel normal and not want to take a nap. Happened on a few occasions. Same thing happens to a lot of people, which I found out later, in the unofficial/official ciltep thread. Cannot afford that amount of sleep, normally I feel fine on 7.5-8 hrs.

7

[quote]PB Andy wrote:

[quote]mattwalshonline wrote:
hows this going?
[/quote]
I had to stop it! When I was doing it I was sleeping RIDICULOUSLY long… like, I need at least 11 hrs of sleep to feel normal and not want to take a nap. Happened on a few occasions. Same thing happens to a lot of people, which I found out later, in the unofficial/official ciltep thread. Cannot afford that amount of sleep, normally I feel fine on 7.5-8 hrs.[/quote]
I have to sleep 12-14 hours per night it sucks

8

[quote]PB Andy wrote:
started out the stack today, if anything noticeable happens in the next couple of weeks I’ll update the thread

Forskolin 10 mg
Artichoke 1 g
Brain Candy

and other misc support supplements[/quote]

Out of curiousity, were you using Caffeine free Brain Candy or the Original? I remember you wanting to go with the Caffeine free because of there being a little too much caffeine in the regular for you, if i remember correctly.

9

[quote]Eazy wrote:

[quote]PB Andy wrote:
started out the stack today, if anything noticeable happens in the next couple of weeks I’ll update the thread

Forskolin 10 mg
Artichoke 1 g
Brain Candy

and other misc support supplements[/quote]

Out of curiousity, were you using Caffeine free Brain Candy or the Original? I remember you wanting to go with the Caffeine free because of there being a little too much caffeine in the regular for you, if i remember correctly.
[/quote]
original Brain Candy. I was taking the artichoke/forskolin first thing, then Brain Candy about 45 mins later.

10

[quote]PB Andy wrote:

[quote]mattwalshonline wrote:
hows this going?
[/quote]
I had to stop it! When I was doing it I was sleeping RIDICULOUSLY long… like, I need at least 11 hrs of sleep to feel normal and not want to take a nap. Happened on a few occasions. Same thing happens to a lot of people, which I found out later, in the unofficial/official ciltep thread. Cannot afford that amount of sleep, normally I feel fine on 7.5-8 hrs.[/quote]

Did you add ALCAR to it? Helps with reducing the CILTEP crash (that’s basically what it is, a big crash causing you to need that much sleep). Basically CILTEP is designed to upregulate cAMP and you add a pretty effective PDE inhibitor (the artichoke extract) which just puts cAMP into hyperdrive. cAMP is cellular level activity so you can see how triggering activity into hyperdrive would cause a crash afterwards.

11

[quote]kissdadookie wrote:

[quote]PB Andy wrote:

[quote]mattwalshonline wrote:
hows this going?
[/quote]
I had to stop it! When I was doing it I was sleeping RIDICULOUSLY long… like, I need at least 11 hrs of sleep to feel normal and not want to take a nap. Happened on a few occasions. Same thing happens to a lot of people, which I found out later, in the unofficial/official ciltep thread. Cannot afford that amount of sleep, normally I feel fine on 7.5-8 hrs.[/quote]

Did you add ALCAR to it? Helps with reducing the CILTEP crash (that’s basically what it is, a big crash causing you to need that much sleep). Basically CILTEP is designed to upregulate cAMP and you add a pretty effective PDE inhibitor (the artichoke extract) which just puts cAMP into hyperdrive. cAMP is cellular level activity so you can see how triggering activity into hyperdrive would cause a crash afterwards.[/quote]
yes, plenty of ALCAR.

I’ve been having much better effects with Brain Candy and Aniracetam/Vinpocetine, actually. Considering trying Huperzine-A as well.

Although I just did read that increased GABA levels can hamper LTP effects/synaptic plasticity. The l-theanine in Brain Candy increases GABA so I was wondering if maybe taking l-theanine every day is not such a good thing for remembering things long-term.

12

[quote]PB Andy wrote:

[quote]kissdadookie wrote:

[quote]PB Andy wrote:

[quote]mattwalshonline wrote:
hows this going?
[/quote]
I had to stop it! When I was doing it I was sleeping RIDICULOUSLY long… like, I need at least 11 hrs of sleep to feel normal and not want to take a nap. Happened on a few occasions. Same thing happens to a lot of people, which I found out later, in the unofficial/official ciltep thread. Cannot afford that amount of sleep, normally I feel fine on 7.5-8 hrs.[/quote]

Did you add ALCAR to it? Helps with reducing the CILTEP crash (that’s basically what it is, a big crash causing you to need that much sleep). Basically CILTEP is designed to upregulate cAMP and you add a pretty effective PDE inhibitor (the artichoke extract) which just puts cAMP into hyperdrive. cAMP is cellular level activity so you can see how triggering activity into hyperdrive would cause a crash afterwards.[/quote]
yes, plenty of ALCAR.

I’ve been having much better effects with Brain Candy and Aniracetam/Vinpocetine, actually. Considering trying Huperzine-A as well.

Although I just did read that increased GABA levels can hamper LTP effects/synaptic plasticity. The l-theanine in Brain Candy increases GABA so I was wondering if maybe taking l-theanine every day is not such a good thing for remembering things long-term.

[/quote]

I actually feel like supplementing GABA is a good idea when regularly using nootropics because many of them actually blocks GABA thus you could end up having some deficiency in GABA. You should try to strike a balance basically.

My current nootropic stack is as follows:

Alpha-GPC 300 mg
Pramiracetam 300 mg
Noopept 15-20 mg

Sometimes I throw some adrafinil or modafinil into the mix, but I try not to use those things too much.

Another stack I like using:

Aniracetam 750 mg
Alpha-GPC 300 mg
Uridine 250 mg
Centrophenoxine 250 mg

I like the first stack though :stuck_out_tongue:

Nootropics, fun stuff.

13

[quote]kissdadookie wrote:

[quote]PB Andy wrote:

[quote]kissdadookie wrote:

[quote]PB Andy wrote:

[quote]mattwalshonline wrote:
hows this going?
[/quote]
I had to stop it! When I was doing it I was sleeping RIDICULOUSLY long… like, I need at least 11 hrs of sleep to feel normal and not want to take a nap. Happened on a few occasions. Same thing happens to a lot of people, which I found out later, in the unofficial/official ciltep thread. Cannot afford that amount of sleep, normally I feel fine on 7.5-8 hrs.[/quote]

Did you add ALCAR to it? Helps with reducing the CILTEP crash (that’s basically what it is, a big crash causing you to need that much sleep). Basically CILTEP is designed to upregulate cAMP and you add a pretty effective PDE inhibitor (the artichoke extract) which just puts cAMP into hyperdrive. cAMP is cellular level activity so you can see how triggering activity into hyperdrive would cause a crash afterwards.[/quote]
yes, plenty of ALCAR.

I’ve been having much better effects with Brain Candy and Aniracetam/Vinpocetine, actually. Considering trying Huperzine-A as well.

Although I just did read that increased GABA levels can hamper LTP effects/synaptic plasticity. The l-theanine in Brain Candy increases GABA so I was wondering if maybe taking l-theanine every day is not such a good thing for remembering things long-term.

[/quote]

I actually feel like supplementing GABA is a good idea when regularly using nootropics because many of them actually blocks GABA thus you could end up having some deficiency in GABA. You should try to strike a balance basically.

My current nootropic stack is as follows:

Alpha-GPC 300 mg
Pramiracetam 300 mg
Noopept 15-20 mg

Sometimes I throw some adrafinil or modafinil into the mix, but I try not to use those things too much.

Another stack I like using:

Aniracetam 750 mg
Alpha-GPC 300 mg
Uridine 250 mg
Centrophenoxine 250 mg

I like the first stack though :stuck_out_tongue:

Nootropics, fun stuff.[/quote]
Interesting. I definitely think the backbone of a nootropic ‘stack’ should be some type of racetam. Haven’t tried anything except Aniracetam because it works great, too bad the half-life is kind of short. Good long-term neuroplastic effects though, if I’m not mistaken.

I do really like Brain Candy, it’s very good to get the day going. The NALT is nice, as is the combo of ALCAR, theanine/caffeine, and cdp-choline. Something about the liquid form makes this one of the better nootropic supps out there, IMO.

However, have been wanting to try out something completely different:

DHA from Flameout (a staple)
ALCAR
Aniracetam
DMAE
Vinpocetine
Uridine Monophosphate
CDP-choline
Alpha-GPC
Huperzine-A
and B-vitamins, maybe in a multi or something

Reason being is a lot of research has been done on uridine… cdp-choline is good and I believe it eventually converts into uridine, but uridine may have even stronger effects (hopefully not too much, I’ll see).

I also have been wanting to try out a combination of both Alpha-GPC & CDP-choline. CDP-choline seems good for increasing dopamine receptor density, while Alpha-GPC seems to be good for increasing both dopamine directly in the frontal cortex/cerebellum. Interestingly, Alpha-GPC seems to increase GABA slightly as well, so l-theanine may not even be necessary.

Another important thing: magnesium! Threonate and Glycinate forms are good, I personally like Elitepro Minerals.

14

[quote]PB Andy wrote:
Interesting. I definitely think the backbone of a nootropic ‘stack’ should be some type of racetam. Haven’t tried anything except Aniracetam because it works great, too bad the half-life is kind of short. Good long-term neuroplastic effects though, if I’m not mistaken.

I do really like Brain Candy, it’s very good to get the day going. The NALT is nice, as is the combo of ALCAR, theanine/caffeine, and cdp-choline. Something about the liquid form makes this one of the better nootropic supps out there, IMO.

However, have been wanting to try out something completely different:

DHA from Flameout (a staple)
ALCAR
Aniracetam
DMAE
Vinpocetine
Uridine Monophosphate
CDP-choline
Alpha-GPC
Huperzine-A
and B-vitamins, maybe in a multi or something

Reason being is a lot of research has been done on uridine… cdp-choline is good and I believe it eventually converts into uridine, but uridine may have even stronger effects (hopefully not too much, I’ll see).

I also have been wanting to try out a combination of both Alpha-GPC & CDP-choline. CDP-choline seems good for increasing dopamine receptor density, while Alpha-GPC seems to be good for increasing both dopamine directly in the frontal cortex/cerebellum. Interestingly, Alpha-GPC seems to increase GABA slightly as well, so l-theanine may not even be necessary.

Another important thing: magnesium! Threonate and Glycinate forms are good, I personally like Elitepro Minerals.[/quote]

Where’s the ‘like’ button? :smiley: