My best combination for anti-anxiety and mental clarity:
Creatine
Cayenne
Lemon balm
[quote]Wise Guy wrote:
[quote]Mikael LS wrote:
Skipped the melatonin as it decreases testosterone.
[/quote]
No it doesn’t[/quote]
yes it does.
My stack didnt really have any effect on anxiety yesterday, not anything that i can say for certain anyway. Excruciating hangover today, so i guess i will give it another try.
[quote]ritch1 wrote:
Isn`t there reseach showing melatonin increases gh levels?[/quote]
That there is.
[quote]Wise Guy wrote:
I always found regular GABA to be useless. I wanted to find out why, so I did some digging around on it.
Apparently, GABA doesn’t cross the BBB very well, thus it doesn’t lead to increased levels of GABA in the brain on any appreciable level.
PhGABA, a derivative of GABA, does cross the BBB well. This in turn will dial down excited neurons and exhibit a calming effect on the CNS.
I’ve found this to be spot on when trying the two substances. Some will say “Just use more GABA” - upwards of several grams.
I’m not sure this is entirely a good idea. Using 2 to 3 times (or more) of an inferior compound to make up for its lack if efficacy to me seems, well, dumb.
I can use 1/4 of the amount of PhGABA and get an even better effect. [/quote]
Look for ‘Picamilon’ (I think that is how it is spelt), a GABA molecule bound to a Niacin molecule, apparently has a much better uptake across the BBB, which they then dissociate.
I have felt the effects of said compound personally, but never compared them to an equal dose of straight GABA.
[quote]Mikael LS wrote:
[quote]Wise Guy wrote:
[quote]Mikael LS wrote:
Skipped the melatonin as it decreases testosterone.
[/quote]
No it doesn’t[/quote]
yes it does.
[/quote]
Wrong.
It has been shown to decrease estrogen levels, which will reduce suppression and if anything will INCREASE TESTOSTERONE.
There were some studies that dealt with administering melatonin and injectable testosterone at the same time to measure LH response, but that wasn’t conclusive, nor was it relevant to natural production.
Would you like to make more pointless claims that are completely the opposite of reality without any research to back it up or would you rather call it a day ?
PS: We had a thread about this already:
[quote]Westclock wrote:
[quote]Mikael LS wrote:
[quote]Wise Guy wrote:
[quote]Mikael LS wrote:
Skipped the melatonin as it decreases testosterone.
[/quote]
No it doesn’t[/quote]
yes it does.
[/quote]
Wrong.
It has been shown to decrease estrogen levels, which will reduce suppression and if anything will INCREASE TESTOSTERONE.
There were some studies that dealt with administering melatonin and injectable testosterone at the same time to measure LH response, but that wasn’t conclusive, nor was it relevant to natural production.
Would you like to make more pointless claims that are completely the opposite of reality without any research to back it up or would you rather call it a day ?[/quote]
If you incubate Leydig cells with melatonin, the secretion of testosterone is inhibited, especially evident if simultanously stimulated with LH. This fact was the basis of my statement. It does not seem to matter when given to animals or humans, as no difference really can be detected, and so I will moderate my previous statement.
Btw, I dislike your tone and will ignore your next post if you dont change it.
Im still not sure if the noops do anything for hangovers. I seem less anxious today than i usually do after two days of drinking, but again, hangovers are rarely predictable. What i am really looking forward to is to see how i feel tomorrow, where i suspect there will be a difference in the “monday morning” feeling that accompany a weekend like this. Any thougths on the matter are welcome, surely there is one or two drinkers on this board sharing my concerns?
[quote]Mikael LS wrote:
If you incubate Leydig cells with melatonin, the secretion of testosterone is inhibited, especially evident if simultanously stimulated with LH. This fact was the basis of my statement. It does not seem to matter when given to animals or humans, as no difference really can be detected, and so I will moderate my previous statement.
Btw, I dislike your tone and will ignore your next post if you dont change it.
Im still not sure if the noops do anything for hangovers. I seem less anxious today than i usually do after two days of drinking, but again, hangovers are rarely predictable. What i am really looking forward to is to see how i feel tomorrow, where i suspect there will be a difference in the “monday morning” feeling that accompany a weekend like this. Any thougths on the matter are welcome, surely there is one or two drinkers on this board sharing my concerns?[/quote]
Study/links/references please.
In the mean time, my DOCTOR, Dr Crisler, probably the most well known and informed Dr on testosterone in the world, recommends it, so I’ll stick to that thank you very much 
[quote]Westclock wrote:
[quote]Mikael LS wrote:
[quote]Wise Guy wrote:
[quote]Mikael LS wrote:
Skipped the melatonin as it decreases testosterone.
[/quote]
No it doesn’t[/quote]
yes it does.
[/quote]
Wrong.
It has been shown to decrease estrogen levels, which will reduce suppression and if anything will INCREASE TESTOSTERONE.
There were some studies that dealt with administering melatonin and injectable testosterone at the same time to measure LH response, but that wasn’t conclusive, nor was it relevant to natural production.
Would you like to make more pointless claims that are completely the opposite of reality without any research to back it up or would you rather call it a day ?
PS: We had a thread about this already:
[/quote]
Exactly
I’m over this discussion.
What is everyone’s opinions on saturated fats effect on cognitive function?
I know the old dogma was that they are ubiquitously bad, and that is being overturned quite drastically as of late; however I have not heard of many people talking about benefits of saturated fat on the brain, combined with many sources on neurology that I frequent making passing comments on to avoid saturated fats.
I do not know whether this is a validated concern, or whether it is old dogma that has not been disproved yet (thus still perpetuated), sadly I do not know much about fatty acids effects on the brain outside of DHA.
Opinions?
Wise guy: My statement was based on a quick look at the litterature, where i found studies (Lukaszyc 1990, Persengiev 1991, Niedziela (1993; 1995; 1997), Valenti 1999, Valenti 2002), suggesting that melatonin inhibits the synthesis of testosterone in the testis. Further reading revealed that the situation in whole animals, including humans, are a bit more complex, and melatonin is even used to increase fertility in rams, and so i revised my statement. I have nothing against being corrected, but i was quite insulted by the rude post accusing me of not having any research to back up my statements.
On topic:
Silverhydra: Hm, good question. A quick look at the litterature reveals that saturated fat is to be avoided for cognitive decline. Before Westlock bashes me again, Greenwood in 1996 showed that rats fed high sfa did worse in cognitive tests than when fed low sfa, Wu has shown in 03 and 04 that sf lowers brain neutrophic factor, which in turn has adverse effects on the brain, Morris found in 06 that sf (and trans fat, im not sure if they discriminated between the two) was correlated to cognitive decline in humans. There is probably a lot more out there, but i didnt come across anything to support the idea that sf should be good for the brain. There is, on the other hand, somewhat good evidence for omega-3, especially the long chained ones, and brain function, although nothing major for healthy individuals.
I still dont really feel anything extraordinary from my noops. I base this on the fact that i keep screwing up small things in the lab, but I could always argue that I would be screwing even more up I didnt do the noops. I do seem to be getting stronger though, even though i am dieting (right now at 7% i think), which might be attributed to increased nervous system activation?
The thing that pisses me off about many of those studies (as I have read a few connected SFAs and Cognition) is that they use either a diet of 40% kcal from SFA, or they fail to distinguish between sources of SFA in an attempt to show what the standard american diet would do for cognition (Good for societal application, not so much for us)
The Neurotrophic factor one is interesting though, I will have to research that when Z12 isn’t making gravity 20x stronger and changing it’s orientation from the center of the earth to my bed. Laterzzzzz
Just came across this;
http://pipeline.corante.com/archives/2010/03/16/betaamyloid_an_antibiotic.php
The idea that beta-amyloid pigments may act as a natural anti-biotic. If it indeed does have defense mechanisms, would this have not so good implications for Centrophenoxine? (Which, if I can recall, reduces amyloid buildup).
[quote]Mikael LS wrote:
Wise guy: My statement was based on a quick look at the litterature, where i found studies (Lukaszyc 1990, Persengiev 1991, Niedziela (1993; 1995; 1997), Valenti 1999, Valenti 2002), suggesting that melatonin inhibits the synthesis of testosterone in the testis. Further reading revealed that the situation in whole animals, including humans, are a bit more complex, and melatonin is even used to increase fertility in rams, and so i revised my statement. I have nothing against being corrected, but i was quite insulted by the rude post accusing me of not having any research to back up my statements.
On topic:
Silverhydra: Hm, good question. A quick look at the litterature reveals that saturated fat is to be avoided for cognitive decline. Before Westlock bashes me again, Greenwood in 1996 showed that rats fed high sfa did worse in cognitive tests than when fed low sfa, Wu has shown in 03 and 04 that sf lowers brain neutrophic factor, which in turn has adverse effects on the brain, Morris found in 06 that sf (and trans fat, im not sure if they discriminated between the two) was correlated to cognitive decline in humans. There is probably a lot more out there, but i didnt come across anything to support the idea that sf should be good for the brain. There is, on the other hand, somewhat good evidence for omega-3, especially the long chained ones, and brain function, although nothing major for healthy individuals.
I still dont really feel anything extraordinary from my noops. I base this on the fact that i keep screwing up small things in the lab, but I could always argue that I would be screwing even more up I didnt do the noops. I do seem to be getting stronger though, even though i am dieting (right now at 7% i think), which might be attributed to increased nervous system activation?[/quote]
Right on brother. Your input is appreciated.
I’m wary of any study against saturated fat. There are so many extraneous variables that are never controlled for, and these studies are often poorly done.
I realize I’m making a basic Type 2 error here, but I feel extremely confident in saying that saturated fat being one of, if not potentially being among the most healthiest foods to eat.
I suspect that where saturated fat gets a bad rap is because the fact that it is often cooked. Cooking creates AGEs which are harmful and cause all sorts of diseases across the spectrum.
I suspect that fruits and vegetables are obviously healthy, but not the holy grail we make them out to be - I believe they escape the gauntlet that is AGEs because they can be easily eaten raw.
Unfortunately, saturated fat doesn’t always escape that.
I suspect if they used unrefined, uncooked Coconut Oil as their saturated fat of choice in these studies, that fucker would shine like no other food could.
Please don’t take this as me being an advocate of a raw food diet - I’m not. Although I think eating more raw food, and cooking your food less, and eating lots of sushi grade fish and rare cooked steak, is probably an excellent idea.
We do have excellent enzyme release systems for assimilating cooked food.
I’m just inferring we probably overload that system.
Yo,
i read these threads about a month ago and got super interested, on a whim i ordered some DMAE, Vinpo, and Oxi. The order shipped from the US on March 10th, and it still isnt here yet (live in atlantic canada) does anyone know if the canada customs will seize racetam shipments?
DMAE is not legal in Canada^^^
Shit, well i guess i learned that one the hard way
god damnmit
[quote]ritch1 wrote:
DMAE is not legal in Canada^^^ [/quote]
For OTC sale, my Power Drive has never been stopped and neither has my DMAE when I bought it on it’s own. Same case with Yohimbine (as I fondle my HOT-ROX up here in Canada)
I would imagine that you would get a letter informing you if a shipment had been seized, since you haven’t, I would check the tracking number you (hopefully) got and see where the package is, or call the company.
For what it’s worth, I have got Piracetam, Ani, and Oxi into Canada with no hassle whatsoever. And they were not hidden in large shipments, but bought by themselves. (High visibility)
yeah ive gotten Power Drive over no problem as well, probably with like a lot of other Biotest supps though…
for some reason i didn’t get a tracking number, but i just emailed the website asking for one.
ill let you guys know how this plays out
Just recently ( I got the package after a 3 week delay after being checked not once, but twice by “other security” I had some novadex xt seized in an order I placed from the states ( I live in Canada… ) I was very unlucky that when I ordered the novadex it was legal here, by the time it got to the borders, it wasen`t…
I got a call from a guy and we talked about the whole “whats legal and whats not”. He was very cool, just doing his job kind of guy and he did tell me they will seize yohimbe. He was acutally showed alot of sympathy saying how unlucky I was, lol. On some sites they wont even sell you DMAE as it often has trouble getting past the borders. Another explanation for the Power Drive getting through can be that Canada will allow a product containing DMAE, but the product must not contain more than a certain amount per serving. Im not 100% certain on that however.
For those who say they got their products they claim are not illegal here, was your package opened? If not, well of course you got your supplements as they don`t open and check every package. If you have a tracking number and your order is held up it will say “package delayed, being checked by government or other security, situation out of our hands…” when you look it up.
The other thing is, and this is what disturbs me the most, is that what goes through is totally up to whos working that day. So one guy may open a package and see yohimbee and let it pass, so even if your package was opened and looked at and you got it, it dosent mean its legal. Its like that guy in the steroid thread who got his “research chems” opened, they seized some stuff yet let him keep the nolvadex. Sometimes, there`s no explanation to how they proceed, you can only hope for the best.
To be honest, I’m surprised Biotest hasn’t just swapped out that micro dose of DMAE for a better form of Choline such as Alpha GPC anyways. Just a small 300mg or so dose shouldn’t raise the price much, and it will be more effective and won’t have issues crossing borders.
Hint hint hint guys…