[quote]duke6j wrote:
Just my 2 cents.
THE most powerful memory enhancer known to science and THE most important brain hormone.
Pregnenolone is a precursor to the bodyâ??s other naturally occurring hormones, including dehydroepiandrosterone (DHEA), progesterone, estrogen, testosterone, and cortisol.1 Pregnenolone is synthesized directly from cholesterol and is responsible for countless functions in our bodies.
By the age of 75, however, the bodyâ??s production of this valuable hormone has declined by as much as 60%,2 and levels of the hormones for which pregnenolone is a precursor have also diminished.
Supplemental pregnenolone is molecularly identical to the pregnenolone that the body makes naturally.3 The raw material to create pregnenolone comes from wild yams (Dioscorea villosa), which are grown in Mexico and other tropical regions throughout the world.
Pregnenolone is the precursor (building-block) for all other steroid hormones. It is converted directly into DHEA and/or progesterone. DHEA converts to testosterone and estrogens; progesterone converts to estrogens, cortisol, and aldosterone. It is this succession of conversions that makes human life possible. Without pregnenolone, there can be no human steroid hormone production.
Unfortunately, the advent of the ‘wonder drug’ cortisone (Cortisol) in the 1950s caused pregnenolone to be passed by for arthritis treatment, since pregnenolones results were much slower to manifest. ‘Coincidentally’, pregnenolone couldnt be patented by the drug companies whereas synthetic variants of cortisone could be (and were) patented.
By the time the nightmarish side-effects of excessive cortisone were widely known by the medical community in the 1960s (these side effects could include psychotic breakdown, adrenal failure, and even death), pregnenolone had been completely forgotten.
Morning is the perfect time to take pregnenolone, and a single daily dose is probably best, since pregnenolone is fat-soluble, and probably follows the circadian highs and lows of DHEA and cortisol (highest in the morning, with a drop to baseline by late afternoon).
Pregnenolone is a naturally occurring metabolite that is made in your body. It is often referred to as the â??mother steroid compoundâ?? because it is the basic raw material for all steroid hormones in the body. This includes cortisone, progesterone, estrogen, testosterone and DHEA.
Although itâ??s the precursor of all steroid hormones, Pregnenolone itself is not a steroid hormone. Instead, Pregnenolone is made from cholesterol in the cells of both the adrenal gland and the central nervous system. Inside each cell there are 1000â??s of mitochondria (tiny power plants) and it is inside these mitochondria that Pregnenolone is produced.
Pregnenolone has been studied since the 1940â??s. Experiments conducted in the 1940’s and 1950’s found Pregnenolone could not only increase the productivity levels and reduce the stress of factory workers, but was also an excellent anti-inflammatory medication for conditions such as arthritis and allergies.
It has long been reported that one of the leading benefits of Pregnenolone supplementation is the enhancement of memory, well in excess of the memory enhancing effects of other substances.
Its role in memory enhancement appears to lie in its ability to assist in the acquisition of knowledge and the long term memory of learned behavior and it does all of this at lower doses than those required by other steroids and steroid precursors such as DHEA. Indeed, in a clinical study carried out in 1995, Pregnenolone was shown to be a potent memory enhancer â?? possibly 100 times more effective than DHEA.
Certainly clinical studies have shown clearly that Pregnenolone acts as a stress reliever. For example, research carried out in the 1940â??s and 1950â??s demonstrated that Pregnenolone reduced the stress of factory workers, with the added bonus of increased productivity.
A study of airplane pilots subjected to stressful situations also revealed that 25mg of Pregnenolone taken twice a day improved performance without causing adverse side effects.
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We discussed preg about a year ago in the first brain booster thread. It can raise prolactin levels. I tried it one more time earlier this year, but even 2.5 mgs sublingually gives me anxiety. Its not part of my current brain booster stack.