Very High Estradiol

Hey folks, I have been dosing 100ml of test-cyp every week.

Total test increased from 215 to 722. Range 348.0-1197.0
Free T is 23.3 Range 8.7-25.1

Estradiol is 65.5! Range 7.6-42.6

My question is, once I am prescribed what ever AI my doc suggest, how long before it starts to decrease my E?

I have noticed my muscles seem tighter, bloated, and I’m not sleeping quite as well, and waking up is slightly more agonizing.

2 weeks ago, I was feeling on to of the world, so clearly E is affecting me here.

Thanks to all for helping me out!

-Lex

im not the most experienced person but i ll give you my thoughts.

i believe an AI like arimidex will start working after a couple of hours taking it. After a couple of weeks it will create stable blood levels so wait until you get blood tests done.

You should start off with 1mg of arimidex per week in divided doses. either twice or three times a week. that should be fine in bringing down your e2 to around 20-30pg/ml and it will make a huge difference for you and all side effects you are experiencing should dissapear. You might be an arimidex over responder and need a small dose. Start with 1 mg a week and after 4-6 weeks do blood tests and adjust accordingly.

john

Hey Lex, The answer to your question can be found somewhere within these threads. I am not as well versed as some of these senior members. Use the search feature. My advice is to cut your Test dose back until your Doctor prescribes an AI. My experience was similar at 100 mg/week. I developed serious sides including gyno and prostatitis until I reduced my dosage. I feel better at 60mg/week than I did at 100. Good luck bro.

BTW, someone on here might flame you for the 100ml/week reference in your OP. I’m aware that you meant 100mg/week.

If you are self injecting, divide your dose and do half m, and half Th.
Your total # is very good, but your Free is at the top of the range which can lead
to problems. Cutting your dose back will help.

The adex you take will slow down the conversion of T to E2, but it won’t do anything about
the free E2 floating around your body and causing problems. It will take a cpl weeks
for it to be eliminated by your liver.

[quote]PKNY wrote:
If you are self injecting, divide your dose and do half m, and half Th.
Your total # is very good, but your Free is at the top of the range which can lead
to problems. Cutting your dose back will help.

The adex you take will slow down the conversion of T to E2, but it won’t do anything about
the free E2 floating around your body and causing problems. It will take a cpl weeks
for it to be eliminated by your liver.
[/quote]

Hey dude,

Sorry for asking this here but i cant seem to send a PM yet. I want to ask something about FREE T. How do you actually calculate it? My lab guy told me the old method of testing FREE T is now not accurate and the correct way to calculate FREE T is to know TOTAL T, SHBG and ALBUMIN. You put these numbers in a calculator and FREE T shows up. Is this actually the correct and most accurate method??

thanks
John

Thank you everyone for your help! It is very, very much appreciated.

PKNY, are you suggesting 50MG Monday, and 50MG on Thursday?

What are the symptoms of high free T? Ill search, but since I just read your post its on my mind! :slight_smile:

Thanks all!

i do 55mg on monday morning and 55mg on thursday afternoon. so its like 3.5 days apart

So, let me give a little dosage histroy.

I was originally prescribes 100mg/every 2 weeks. This left me feeling very strange.
(Did this for 2 months)
I asked the doc if I could do 50mg per week instead. Answer is yes
(did this for a month) Didnt feel any better or worse

I then asked if I could incrase to 100mg/week. Answer is yes
(I def felt better after two weeks!) but got blood tests back after maybe 2 weeks of increasing to 100MG/week

So, im wondering if I should go to an even lower dose than 50mg/week? Maybe 100 however its broken up is still too much?

@Jon, PM’s are disabled on this site for some reason.
Quest gives a Free T # with their Total T lab,
I’ve read about the method and it’s pretty accurate.
Your friend is correct though, it is normally calculated w/ TOTAL T, SHBG and ALBUMIN.

The problem arises when you are taking a relatively small dose of T
and have total around 600-700 (which is very good in a TRT context),
but your Free is at or above the range for Free T. Having #'s like that
suggests low SHBG which can make TRT tricky to balance.
If SHBG is very low (below 10 or in single digits) it makes TRT really difficult.

High Free T sounds ideal, but in many cases it makes you feel as bad as low T.

@Hacker, based on your #'s I think you will be fine staying at 100mg per week,
just split that dose to Half M, Half Th…Alternatively, you can do 33mg M-W-F, but
the difference probably will be small.

I’m betting you’ll be fine splitting to 2 days a week, and the addition of Adex.
In the mean time, you can try two things to lower the amount of e2 that is floating
around in you now (Bit of Bro Science) : Green Tea, and cruciferous vegetables (Broccoli, Cabbage, Br. Spouts).
There is a lot of info wrt to those things helping to lower e2, but not as a first line defense like
Adex, or Aromasin.

100ml/week

I believe that is delivered via a martini.

Thank you! I feel better knowing is resolvable.

Here is SHBG numbers.

Sex Horm Binding Glob, Serum 23.1 (Range) 16.5-55.9

Since I normally take 100mg on Friday’s, should I take 50mg today to start splitting the dosage, or should I wait till Monday for my first split dose?

23 is a very good # for SHBG.
Splitting the dose and Adex will get you back in the zone.

If you normally take your 100mg on Friday, just take 50 today and 50 Tuesday.

Hopefully my doc will prescribe Adex tomorrow! Now at lunch gorging on broccoli!

The preferred method is getting your doc to Rx it.
If he won’t (some are just clueless) you can always buy it online from a company that
sells it as a “research chemical.”

Funny thing, I think my doc wil prescribe what ever I want it seems, my hurdle is getting the insurance to pay for it. They would not pay for my insulin! They would not pay for test-cyp! They did pay for Androgel… Maybe they only pay for meds that dont work? :slight_smile:

Got a script for Anastrazole (Arimidex), 1MG.

Also, is Adex short for Arimidex? Or are they seperate AI’s?

Thanks!

Adex is usually the liquid research chemical name for Arimidex.

I don’t understand why an insurance company will pay for Androjunk, but not Cyp…same thing
happened to me.

Start slow with the adex, some guys are sensitive to it. Start out with a qtr pill if you can
cut them that small, if you have to take a half it’s ok too. Take it E3D.

It’s pretty strong stuff, so beware if you are an over responder to it.
If you are an over responder It will crash your E2 which
will kill your libido, boner and make your joints hurt. E2 too low is just as bad
as E2 too high.

anastrozole is the chemical name for brand name Arimidex, now generic drug in USA.

Read the stickies, all explanations are there so we do not need to repeat things.

When you inject once a week, your T levels change a lot. Lab timing then determines the lab results.