[quote]derek wrote:
My limited knowledge of the whole “cholesterol issue” is this…
High carb/sugar diets are very inflamatory to the arteries (high blood glucose/high insulin response). The body uses cholesterol to create a “band-aid” over the inflamed areas within the arteries.
If you cause enough inflamation by eating junk or even many “healthy” foods/sugars, you build up too many cholesterol “band-aids” and start to clog the artery with what SHOULD be a harmless protective response.
It’s kinda like running through a thicket of thorn bushes. You get cut to shreds right? So you apply several band-aids on your wounds so they can heal. The problem occurs when you keep on running through the thorns and keep piling up the band-aids.
Soon enough you appear to have a “band-aid issue” but the truth is you need to quit running through the thorn bushes (quit eating junk carbs).
Doctors who advise patients to cut/medically reduce cholesterol levels equals them telling you to cut your band-aid usage. It’s merely a RESULT not the cause. And from what I can see, rather harmful.
Make any sense?
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I’ve been thinking about this alot lately. I’ve been curious wether it is the chronic hyperinsulinemia or the elevated glucose itself that is responsible for the inflammation. I don’t know which is the chicken and which is the egg in this scenario, but I’ve got a hypothesis.
It took quite a bit of pondering for me to stumble on one reason glucose itself is inflammatory. It can glycosylate proteins (as the Schiff base). Now, it’s not very good at it compared to other sugars, thanks to it’s stereochemistry, but the fact remains. Glucose is a reactive, not particularly friendly molecule to have floating around your system. I think this is one of the reasons caloric deprivation is beneficial, it simply decreases the total amount of glucose we’re exposed to, lowering the area under the curve, if you will. I also think this is why exercising and eating lowish, paleocarbs is so anti-inflammatory, you’re keeping blood sugar levels lower/more stable and disposing of the glucose you have, so it can’t run around interfering with cell surface proteins.
Systemic inflammation is an incredibly interesting topic, so I couldn’t help the hijack. I think an inflammation thread may be in order…