Different folk seem to do better with different levels. There will be a number of reasons for this which are rarely discussed, arterial stiffness could be one of these reasons. In general and from what I can tell the majority of healthy and “youngish” males should aim for mid range e2.
When systemlord says “natural men”, i believe he means men with normal, in range levels of testosterone. That would apply to ones on TRT as well that are in range.
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Thank you guys for all the knowledge you have provided I have made notes on all of this.
I have one more question. For the longest I know men have been struggling with sensitivity while using TRT. Has anyone figured out how to regain sensitivity. Or what about TRT effects sensitivity to begin with ?
Adding HCG can help with sensitivity but can also raise e2 and prolactin potentially leading to some ED. It’s important to find the sweet spot. There’s more chance an AI will be required when using HCG.
I thought using a A.I was bad and it was better to control your E2 by just lowering your dosage
That’s a bit too black and white. There are many cases where an AI is necessary.
From experience, I have noticed an improvement in erections the past few weeks since introducing a microdose AI into the mix. Is it where it should be? No not 100% and will likely need tweaking once blood work is analyzed, but the improvement since introducing the AI signals to me that my erection issues are E2 related.
What do you mean?
Is it not doing the same thing by just lowering the dose which would end result would be your E2 would be lower as well
I think in the case where lowering your dose puts TT too low to be of any benefit, then adding an AI while keeping your TT in a good range may be needed.
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Like I said nothing is black or white. Especially in the case of HCG use which can complicate things tremendously. Your balls are producing hormones in addition to the exogenous stuff. Finding a good balance can be more difficult
I see what you mean. What happen to that whole thing that was going around that men should stay away from A.I if needed. So I take cypionate and hcg and then adding an A.I do you think It trying manage all these medications and trying to keep your hormones balanced is impossible.
If something was to throw you body off how would you even know which medication is throwing your body off. And then when you do find out how would you even figure out what range your body needs to be in ??
Well some of those were literally equating AI with rat poison. But if you don’t need them, don’t take them
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I see
Question is how does one know when to start taking a AI. I have some water retention I have gained a lot of belly fat and my face has became bloated. Also do you base taking a A.I off of the range of your E2?
Combo of symptoms and lab work, since a lot of the high/low sides overlap. So if you’re feeling off, get some labwork, see where e2 is at (in relation to TT) and start with a very low dose. Or, adjust your protocol if you want to first. Inject more often, lower dose, etc. if that doesn’t work, they make .125mg anastrozole tabs that you can take day after your injections 1-2x per week
Thank you i will get labs done and return with the results hopefully I will be able to get some assistance from you with them.
As a side note from my original post, my doctor discussed the option of trying Bupropion to see if this helps. Does anyone know what the rationale would be behind this and why this may help?
My understanding is this medication increases dopamine, so my doctor may suspect a dopamine deficiency… but is there a link between dopamine and erections?
Many thanks
I have extensive experience with Bupropion. Its effect is to increase the amount of dopamine that is in circulation between the synapses.
His thought process is to see if increase dopamine will help with erections. Can’t hurt to try it.
Sometimes the problem is not TRT. I say this so that you can stop chasing your tail around with Hormones, and look into other possible issues that may be the cause of your issues. I used to believe that high E could cause many things but thats not the case with me. I know for a fact that Estrogen promotes endothelial health and increases Nitric Oxide. So this must explain why I like drinking estrogenic beer with my No AI stance. I really do experience great hard ons when I drink beer. Anyway Im going off topic, but for some the problem is in Nitric Oxide production.
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Thanks for response guys.
@roscoe88 I know it is all individual, but in general terms how is Bupropion likely to make me feel? Also, if it was taken on a 3 month trial say, if there was no improvement and I wish to come off, is this a simple process?
@middleages agreed. I need to get my hormones in check but am also looking at other causes. Cholesterol is in check, as is BP so I know the issues are not there. As we have discussed I am really quite heavy for my height so will be getting leaner to see if this helps. Am also looking into NO as you say. Other than daily supplementation with Citrulline, is there anything else that can be done?
Many thanks
Yep
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