Tell me about it. Went ahead and ordered an oral version that he may find easier to take. Finger’s crossed
Combing through here and elsewhere doing some research on nandralone. I’ve read the abstract here but don’t see a comparison to testosterone as it relates to reversal of normal, acute stress-induced down-regulation of the beta-1/2 receptor response. Where are you finding this?
From the 4 week head-to-head:
Conclusion: Four weeks of treatment with testosterone or nandrolone had no beneficial or adverse effects compared with placebo on cardiac function in healthy young men.
So as it relates to morphology (insofar as morphology relates to the outcome measurements), nandrolone had no impact in this short study. Apropos to modulation of normal, acute stress-induced down-regulation of the beta-1/2 receptor response, we have evidence to suggest it does at a HED (200 lbs) of 1,540mg/wk. Likewise, I’ve located a study that finds testosterone also modulates beta-2 receptor expression, but not beta-1:
Data obtained from Western blots revealed that testosterone upregulated the expression of β(2)-adrenoceptor, Gs, Gi(2) and bcl2 levels, downregulated the expression of β(3)-adrenoceptor, Gi(3) and GRK2 levels, and did not modify the expression of β(1)-adrenoceptor levels in the hearts of castrated rats subjected to doxorubicin-induced heart failure. Analyses of serum 17β-estradiol concentrations test confirmed that these effects of testosterone were exerted through the androgen pathway.
It’s unfortunate this stuff is behind paywalls. I would like to explore the dose-response and other facets, especially the details of the study on testosterone. I think I may purchase the study to find out.
That HED table doesn’t look at all like my calculations for the study you posted earlier and I commented on: Nandrolone-pretreatment enhances cardiac beta(2)-adrenoceptor expression and reverses heart contractile down-regulation in the post-stress period of acute-stressed rats.
In this study, they administered 15mg/kgday. Referencing the conversion guidelines from the following: A simple practice guide for dose conversion between animals and human, my math is as follows:
15mg/kgday * 0.162 = 2.43mg/kgday HED
This comes to 0.453kg/lb * 2.43mg/kgday = 1.1mg/lbday, giving us a final weekly HED of 1,540mg nandralone for a 200lb human.
Perfect - thanks for that. To what do the numbers in the ‘Ref’ column correspond?
Update: the study on Testosterone modulation of cardiac β-adrenergic signals in a rat model of heart failure administered 2mg/kgday, a HED of 205mg/wk (200lbs).
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