I want to dedicate this thread to anyone that has been on the above long term…
And any information that anyone thinks is worth contributing to Testoreone Undecanoate 40mg caps.
I have been taking test orally for over 13 months now and have felt great but as of yet know nothing of the long term affects… Most the studies I have read so far have been for less than a year… Im still researching.
Is there anyone else out there that has been on undecanoate 40mg caps long term?
If so I would appreciate your input.
So far I have found it to be absolutely brilliant, giving me lots of energy and no issues.
Not shrunken family jewles either…
I’ll keep you guys up to date with how I feel on it.
I admit to worrying a little about the affects of having the repeated spikes and troughs while taking it but so far all good.
Again please feel free to contribute if you think you may have any info on this topic worth a mention…
Just something I have googled on it… Some I understand, some I don’t!
“14.3.1.5 Testosterone undecanoate
When testosterone is esterified in the 17Ã?-position with a long fatty acid side
chain such as undecanoic acid and given orally, its route of absorption from the
gastrointestinal tract is slightly shifted from the vena portae to the lymph and
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412 H.M. Behre et al.
Fig. 14.2 Single-dose pharmacokinetics of testosterone undecanoate after oral administration of
120mg of the ester to 8 hypogonadal patients. Because of high interindividual variability of
testosterone serum concentrations after administration of testosterone undecanoate, individual
curves were all centralized about the time of maximal serum concentrations (time
0). Asterisks indicate significantly higher testosterone serum concentrations compared to
pretreatment values (basal) (mean ± SEM).
reaches the circulation via the thoracic duct (Coert et al. 1975; Horst et al. 1976;
Shackleford et al. 2003). Absorption is improved if the ester is taken in arachis oil
(Nieschlag et al. 1975) and with a meal (Frey et al. 1979; Bagchus et al. 2003). After
oral ingestion of a 40 mgcapsule, ofwhich 63% i.e. 25 mgis testosterone, maximum
serumlevels are reached two to six hours later (Nieschlag et al. 1975). Thus,with 2 to
4 capsules (80 to 160 mg) per day substitution of hypogonadism can be achieved.
Testosterone undecanoate pharmacokinetics after single-dose administration
were tested in eight hypogonadal patients and twelve normal men (Sch¨urmeyer
et al. 1983). Directly before and at hourly intervals after oral application of three
times 40 mg of testosterone undecanoate in arachis oil taken together with a standardized
breakfast, matched saliva samples, as a parameter for free testosterone at
the tissue level, and blood samples were collected hourly for up to 8 h. After administration
of testosterone undecanoate, serum and saliva testosterone always showed
a parallel rise and fall, as demonstrated by a constant saliva/serum testosterone
ratio. On average maximum levels could be observed five hours after testosterone
undecanoate administration.However, the serum testosterone profile showed high
interindividual variabilityof the timewhenmaximumconcentrationswere reached,
aswell as of the maximumlevels themselves that ranged from17 to 96 nmol/l.When
the individual serum concentration versus time curves were centralized about the
time of maximal serum concentrations, serum concentrations significantly different
from basal values were seen only two hours before and one hour after the time
of maximal serum concentrations in hypogonadal patients (Fig. 14.2) (Sch¨urmeyer
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413 Pharmacology of testosterone preparations
et al. 1983). Based on this observation it can be deduced that even with administration
of testosterone undecanoate 3 times daily, only short-lived testosterone peaks
resulting in high fluctuations can be obtained.
This judgment is in agreement with the data of a two-month multiple-dose
study with testosterone undecanoate for replacement therapy in hypogonadal men
(Skakkebaek et al. 1981). Applying a double blind cross-over design, serum testosterone
levels were studied in 12 hypogonadal patients to whom 80 mg of testosterone
undecanoate had been administered twice per day 12 hours apart.Whereas
four hours after administration of testosterone undecanoate a significant increase
of testosterone serum levels was observed compared to the placebo group, twelve
hours after administration no significant difference in testosterone serum levels
between treatment and placebo control group was seen. Even four hours after
administration, in four of twelve patients testosterone levels were still below the
lower level of the normal range after both one month and two months of treatment.
Asignificant marked variability between subjects aswell aswithin the same subjects
has also been observed in other clinical studies (Cantrill et al. 1984; Conway et al.
1988).
The original preparation of oral testosterone undecanoate had to be refrigerated
(2â??8â?¦C) in the pharmacy for reasons of stability, whereas patients must store it at
roomtemperature to ensure optimal absorption. The shelf-life at roomtemperature
is only three months. Therefore, a new,more stable pharmaceutical formulation of
testosteroneundecanoatewas developed inwhich the oleic acid solventwas replaced
by castor oil and propylene glycol laurate. This new formulation can be stored at
room temperature (15â??30â?¦C) for three years (Bagchus et al. 2003). According to an
unpublished randomized multicenter study in 49 hypogonadal men, oral administration
of 2 Ã? 80 mg or 3 Ã? 80 mg of the reformulated testosterone undecanoate
might result in more physiological and stable serum testosterone levels.”
