The SHBG of 2nmol wasn’t mine. The lowest I’ve ever tested is 9nmol, highest is 27nmol
I’m sure I could get it down to 2nmol if I took GH/anything that causes insulin resistance + taking strong androgens. But I wouldn’t do that
I don’t know how much I aromatise, I rarely check E2 nowdays
What is your TRT regiment?
100-125mg/wk test E
Taken 1x/wk via 19 gauge needle or insulin syringe. Fluctuates depending on how much effort I feel like putting into it
Mine as well for the last 3 years. But for some reason I can’t keep my E2 in check at that dose. I have to take a 0.125mg of anastrozole with every shot. M/T to keep my E2 in range. I experience water weight and mood swings if I don’t. It blows me away that some guys here do 250-300/w with no AI as their self prescribed TRT protocol and have gotten away with it for years. No way could I do that.
EDIT: Ever get a warning from the forum AI you are talking to one person too much? I just did. So I guess I am done on this thread. I enjoyed our chat unreal.
So either a harpoon, or a slin pin? Maybe you meant 29 gauge?
No, 19 gauge
Primoteston comes pre-packaged with a 19 gauge syringe
I would inject it into a slin pin then. That is a big needle.
Fun fact, prior to bodybuilding Matarazzo was a boxer
I made a comment on mpmd video when he was talking about genetics and some people blowing up on low dosages. I said basically what my opening post on this thread said, that it is blood levels, not dose that impacts results and sides, and that we shouldn’t conclude that someone has bad genetics because of a poor response to a dose.
He found a research paper, which showed that the lower end blood results from a dose would be about 3x less blood concentration, than the upper end. I feel that alone is a giant factor in ones response in regards to muscle gains / sides.
This video, may or may not be in response to that, but he did go over the topic on point Imo.
Your approach is better than dose because it includes one of two factors that determines response.
The two factors are pharmacokinetics (which is essentially your blood levels after a dose and the changes of them) and pharmacodynamics.
The problem is that (at least in my opinion) individual response differs largely because of individual differences in dynamics. Binding affinities, down-stream molecules like transcription factors, tissue-density of ARs and so on.
It’s the same reason why some get gyno while others get bloating and still others get nothing side effect-wise from testosterone.
Nuclear receptors and their drugs are way more complicated than just a binding and an effect. You just have to look how the opinions on the free hormone hypothesis start to change to realize that it’s a complex process and therefore a crap-shoot how you’ll respond.
New approaches in the scientific community are tracking response and looking at genotypes. This will likely not happen for illegal substances as you need HUGE cohorts. The approach is way better than anything of the past but it is likely still not the end of the road.
All in all, your idea is better than just looking at dose but it misses a key element which is the biggest determinant.
This is a blood sample on ~750mg test/week with the dosing split E3D of 300mg/ml, dosed ~350mg per injection.
Anybody else have lab work to show for X amount of test (not TRT levels). Curious how my response is compared to others.
Labs taken 24hoirs post injection 7 weeks into blast.
Well, on 200 mg per week, I was at 1223 ng/dl. I pinned 62.5, 62.5, and 75 m,w,f. I pulled labs Friday morning. If it was a linear relationship, I would be at almost 4600 ng/dl at 750 mg/wk in the same pinning schedule.
They can’t be linear though… my TRT is higher than yours for those same TT numbers. You just need to blast some test and get us some numbers in the name of science!
There’s also the lipases that break down the carrier oil, allowing the body to access the drug from the depot. Then the esterases that hydrolyze the ester, eventually releasing the active hormone. These enzymes act differently in different people, affecting absorption rates. As you said, this shit is complicated; so many factors influence our individual responses.
Wow wanna_be your free T is not even double with a TT of 4000? Am I reading that right?
I ask because when I blast my TT never gets to 4000 but my FT is always 4,5,6x the max range. Here are two different blasts with free T out the wazoo. I don’t get it.Is your SHGB exceptionally high?
I’m confused by his labs. It has two listing for free t. Anyone know which one is what we would normally call free t?
After looking, is it possible that the first is the trt lab result, and the second is during the blast?
@mnben87
I am assuming you are questioning wanna_be blood tests because they are not standard by any means?
Yeah, one of them is double range, and one is like many multiple times over (what it should be for a blast imo). I’m thinking the second is the free t in blast?
@wanna_be do you live in America? Do you use Labcorp or Quest? Those are the only two labs anyone trusts.
My SHGB is always very low, like 15. Also that is a labcorp test and yes, good ole US of A
