Happy coincidence. My BP was running high and has since calmed down with a reduced dose of MENT and the valsartan. After I got on it I read everything I could find and learned that ARBs are miracle drugs.
Still scratching my head on what MENT is?
I have a favorite blood pressure medication 2 mg Doxazosin because its secondary application is reducing BPH which I get from Blasting. Also 2mg Dox plus 5mg cialas is a know combo for improving Vascularity.
Love your post. I don’t know if I’d agree here though. Other AAS have the ability to interfere with GC function too, Tren does it the best though (the recomp effect people are reporting could be explained by that). Also, chemically Tren is a steroid, but it has some SARM like activity. I don’t agree with some of the reasoning the researchers use though (calling it SARM like only because it doesn’t get 5a reduced).
Yeah, I think it’s fair to argue that it is both a SARM and not a SARM. There’s a decent enough argument for both. Schrödinger’s Tren would perhaps be the best description.
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7a-methyl-19nortestosterone.
Thank you. The AAS Trestolone
You don’t need to use Bitcoin. All cryptocurrencies are quite volatile ATM, but if you use a crypto worth less per coin the fluctuations shouldn’t be that great
To note, I don’t buy crypto for “purchases” these days, it’s more for perhaps a long term investment. Try find a vendor that accepts monero. Transactions with monero are arguably more secure anyway.
I’ve been getting into cryptocurrency and to a degree stocks.
It just depends on which side of this curve you bought in. When I started buying bitcoin they were 18K and when I was buying my hobby drugs of choice Bitcoin was 60K. So TE/HGH/Anavar/Anastrozole was basically free.
My father also got lucky with btc, purchased a full bitcoin when it was like 10k
The only one I made a decent profit from was dogecoin and to a smaller degree, etherum classic and ripple.
Interesting I only use coinbase and you can’t buy dogecoins from them.
Supposedly they’re are going to be integrating that in the next month or two.
It definitely is; SHBG has its own cell receptors. Here is a semi-recent paper about its various effects:
https://www.hindawi.com/journals/ije/2016/6437585/
Here’s a couple of nuggets of wisdom from the paper (they’re using Te as an abbreviation for testosterone):
“It is well known that SHBG reduces cellular uptake of Te; however we have demonstrated that SHBG may also maintain stable levels of biofunctional Te and physiologically relevant intracellular Te levels by reducing Te glucuronidation and efflux.”
“When SHBG is reduced or absent, excess free Te may enter cells and oversaturate the ARs since it has been reported that AR saturation occurs at approximately 2-3 nM in prostate [26]. The LNCaP cells may respond to this by rapidly glucuronidating and effluxing the excess Te.”
For those who are not nerds, glucuronidation is the body’s way of “tagging” a molecule for excretion by the liver or kidneys. Glucuronidated testosterone is, for our purposes, worthless.
TL,DR: SHBG is very important - don’t intentionally try to lower it unless you are an outlier who has ridiculous amounts of the stuff.
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I guess my questions would be:
Can T+SHBG attach to the AR?
Can T+SHBG be aromatized into e2?
How does T separate from SHBG (or does it)?
That is for sure lol. I’ll read these when I get home
If SHGB’s job is to regulate your T level so you don’t overwhelm your receptors. I wonder why it drops so low when we inject a T overload with cycling or blasting? One would think the body would see all this T and make a ton of SHGB to prevent a receptor overload.
On my last blast my SHGB which has been running about 16 for the last two years dropped to 6.
The blast was 500/w for 12 weeks, Anavar for 4 weeks then winny for 4 weeks.
March 2021 SHGB
May 2021 SHGB post cycle bloods.
Just a hypothesis on it, but lower SHBG results in a faster clearance of testosterone. Perhaps that is the bodies way of saying, wow, this is a lot of Test, let’s flush it out a bit quicker. Again, just a hypothesis.
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I’ve seen lower. Saw SHBG of 2nmol/l on a guys bloods once.
Can anyone on here beat that?
I’ve speculated in the past, though not online, that free hormones are especially important for mediating the fast effects of sex hormones via GPCR receptors like the GPER while SHBG bound sex hormones are especially important for intercellular action.
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This was gonna be my guess as well
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I am not sure a super low SHGB is something you brag about. In fact, My recent post cycle bloods scared the shit out of me. I am now on 80mg Tcyp/wk for the next 6 months. It is time I clean up my bloods. Get my lipids back on track, SHGB above 20 and see if I can finely stop needing anastrozole. Look at my march 2021 bloods TT/FT/E2 that is on 125mg/w Tcyp. I am a E2 generating machine and I don’t know why. An honest assessment I am 25% body fat. I don’t have a 6pack I have a 2 pack, haha
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