[quote]ActivitiesGuy wrote:
I’m not really sure about transmission of live-attenuated virus vaccines into others. Aragorn, do you know what happens if an unvaccinated, immunocompromised person stands next to a vaccinated child on the street and catches the little bugger’s live-attenuated-virus-carrying sneeze? My guess is that it’s pretty low risk.[/quote]
Hmm, I’m not sure. I’ll have to do some looking into this. Seems like this might be a good question for your other epidemiology friend as well. I misunderstood what Airtruth was asking I suppose.
My gut reaction is that with a non-immunocompromised individual there is no way to become sick or infected. Immunocompromised individuals are a hard question. It is known that most infections require some minimum threshold of virus particles to be present, but on the other hand that is a very disease/illness specific number. More virulent strains can become infectious and symptomatic at very low #'s of molecules. Interestingly this is one reason why Ebola is such a bitch, because my understanding of the science is that Ebola needs only about 10 individual molecules (I may be misremembering the actual number, I just remember being shocked at how few were necessary). But again this is a murky issue and especially so with Ebola.
I think I’ll look into this a bit. Regardless I think it bears repeating that even if this ends up being a legitimate concern, it is only at a very specific time after the vaccination shot–say 2 days. Before and after it is not realistically possible because your immune system has killed whatever little virus was present or because the attenuated virus vaccine hasn’t circulated in your system enough to be excreted via any known pathway.