No problem at all.
I’ve always taken an AI other than the period below.
I started on the cookie cutter protocol mentioned previously.
I’ve pretty much taken 0.5mg every 4 or 5 days the full time on trt and still had values close to or over E2 reference range. The problem is the HCG for me. I moved to 0.25 e3d towards the end.
Arimidex which is a brand of Anastrozole stops testosterone being converted into E2 in the first place.
Nolvadex binds too the oestrogen receptor meaning free E2 floating about your body can’t bind hence can’t cause gyno.
You could say that Arimidex is proactive e2 management and Nolva is more of a reactive measure to combat gyno for instance.