I’ve never taken phosphatidyl serine before & yesterday took 600mg on an empty stomach and didn’t ‘feel’ anything - no calming feeling or lowered heart rate. I still felt stressed.
I was a bit stressed at the time, nothing major but I certainly would have noticed returning to a more calm state of mind.
6 hours later I took another 600mg just before sleeping & again didn’t notice any effect.
Should I feel PS or is lowered cortisol not something you feel?
Thanks
Could be that the PS already lowered your serum cortisol levels. However, if the adrenaline molecules (cortisol increases the production of adrenaline) are still attached to your beta-adrenergic receptors, you keep experiencing feelings of unease (when adrenaline binds to these receptors, your nervous system gets amped up which leads to increased brain activity).
You need COMT and magnesium to dislocate adrenaline from these receptors. If you have Slow COMT, the anxious/stimulating feeling last longer. If you have fast COMT it is the opposite.
Also don’t forget, worrying increases cortisol and adrenaline output as well as any other form of stress (whether it is physiological of psychological). While PS helps to lower cortisol levels during acute stress and regulates metabolism, you can still experience stress if your brain keeps instructing your adrenals to pump out more cortisol.
Brilliant thank you!
What gene test should I get to see what COMT gene I have, please?
Excellent about magnesium - I have magnesium taurate at home 600mg capsules. Is that a good enough version of magnesium?
Should I take magnesium immediately after training to decouple adrenaline & then 30 minutes later PS with carbs & protein to lower cortisol?
Honestly, I have no experience with gene testing so unfortunately I cannot answer this question for you. May I suggest however that, if it is not that important to you, you simply evaluate how long it takes you to calm down after a stressful event? While this by itself does not give you a clear cut answer, it might give you some insight in how fast you break down adrenaline and what COMT gene you have.
For example, when you’ve had a heated discussion with someone or something has made you angry, does that anger linger for a long time? Do you have a hard time calming yourself down or letting things go? Do your muscles tense up hard and do you have trouble bringing your heart rate down after you saw red?
If you really like to know what gene you have by all means go ahead and take the appropriate test. The protocol for a slow COMT gene stays the same nontheless.
Magnesium taurate is a great option. However, if you’re after increasing magnesium concentrations in the brain more than the rest of the body, I would go with magnesium L-threonate. Both variants serve a similar purpose though which is calming the nervous system by dislocating adrenaline and increasing synapse density. Magnesium l-threonate may cause headaches at first but this usually goes away after a few days to a week.
If you decide to go with mag taurate or l-threonate, use them either post- workout (if you don’t have to work anymore) or prebed. Magnesium chloride is better peri-workout because it increases magnesium absorption in the muscles and joints. Because the magnesium is applied transdermally, it has a very high absorption rate (better than capsules). Use 250-500 mg in one go. Don’t go above 500mg each time you apply it though. Magnesium absorption works better in smaller doses.
PS with carbs and protein post-workout is fine. But you might want to consider using glycine instead of PS. It decreases cortisol as well, increases circulating serotonin levels, activates mTOR and it is dead cheap so you can use the extra money to invest in magnesium l-threonate which is usually more expensive than other forms of magnesium. It’s up to you though.
Brilliant, thanks for such a detailed response!
I usually calm down after anger pretty quickly & it takes a lot to get me angry.
I’ll get some mag l-threonate & glycine 
Me and my friend took phosphatidyl serine. He like it, he told me that when he take it at night he is falling a sleep right on his sofa. It knock him so much.
I took it, felt tired and then went High. I was not able to sleep all night long. Next day i retry again. Was not able to sleep again, falling a sleep but waking up every 30 mins.
Its strange how it can work for someone and not for some1 else.
thats been said, maybe its just not for you and you can do like me and throw it in the garbage
It sounds like your body tried to restore equilibrium by pumping out more cortisol to counter the PS.
I took it last night after magnesium & was fine
Do you guys take it only a few times a week to stop your body over producing cortisol to adapt to the PS?
That was my plan to only take it Mon, Weds, Fri after weights 
thats exactly how i felt. it was pumping out more cortisol. Looks like my cortisol wanted to take out of my body.
what you guys think about it ? i should continue it ?
If you don’t see results from it or it doesn’t make you feel better, why should you keep using it?
Don’t forget that, while there is some common ground to be found amongst all people, supplementation is highly individual.
Not everyone reacts the same way or has the same needs. Even though two individuals might share the same symptoms, the supplement protocol can still be entirely different.
It all depends on your personal deficiencies (if you have those) and what helps you to bring balance again.
I’d also recommend to always do your research on supplements that you want to buy. There have been numerous studies on the effectiveness of creatine and protein supplementation. The average lifter knows this. But there are 1000’s of supplements out there that have not been well researched and people buy them without even knowing what it does to them both in the short and long term.
Therefore, it is a wise thing to keep your money in the bank until you have checked out some reputable sources (this does not mean one 8 week study with like 15 participants, look for meta-analyses or multiple long term studies (16 weeks or more) with a greater number of participants) on the supplement(s) that you wish to purchase.
i know that. I stop taking it. My question is why it was doing that to me, pumping out more cortisol.
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