As far as semaglutide, I thought there was only one recorded case of intestinal obstruction so far? Still, I get your point. However, people using it for weight loss would probably be on it for a very short time.
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Berberine when combined with Black Pepper Extract provides a huge kick in terms of energy. On it’s own, it provides a weaker kick. Combining 600mg Berb + Pepper extract & 1 Hot-Rox really ramps up your metabolism vs 2 Hot Rox alone. Highly recommended.
Also highly recommend 3 Indigo-3G in the AM before 1st meal, and then 1g-1.5g Cinnamon straight after every meal.
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I have been hospitalized 4 times for pancreatitis. No shit, one of those times I was ok with dying it was so awful. The other 3 times were beyond horrible, but apparently heaven was not ready for me and hell didn’t want me.
As it turns out my gallbladder was the cause of this so they yanked it out. As a type II diabetic I would not touch Ozempic with a 10 foot pole. Another round of pancreatitis will probably kill me.
Currently take Actos, and a Fenofibrate with no sides.
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Definitely not fun. My gall bladder came out the first time (said it was functioning at 0%).
Now if I have any symptoms of pancreatitis at all I hit the ER. Last time I caught it early and was out of the hospital in 3 days.
The first time I had it I spent 3 days doped up on dilaudid to get through it.
Just my opinion, there has to be some caveats for it to work in this way. The main thing being on a path to that goal BF% or look before using it (using it as a tool to speed up the cut). Using minimal effective doses to allow one to cut at a reasonable rate. Not getting so lean that it isn’t realistic for that person to maintain after.
I believe most users will be long term users. I do think there is a place for short term use as a PED though (for athletes, BBers). I think there is a difference between the typical user of these drugs and those looking to strip off the last 10-15 lbs to be jacked. The latter is already spending time in the gym, and eating better than the former (at least on average).
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For those interested, I can give you some pointers. One of the only negatives about this class of inhibitors is that along with fat, you can lose some bone density, muscle, tendon strength, etc.
The best way to prevent that is two things. #1 continue resistance training regularly
#2 add low dose HGH to your daily routine
The GH protects you from losing anything you don’t want to lose and makes the fat loss happen even faster. If you want a third very powerful weight loss tool, start a strict time restricted eating schedule. Feed from 10am to 6pm. this includes drinks other than water
I have done two cycles of this so far, I prefer Liraglutide to Sema, but the first time I lost something like 26 lbs. Over the course of 2 years I’ve gained about 18lbs back, from working a new sedentary job and doing less cardio. I’m on it again now, for two weeks, down 8 lbs. I didn’t experience a giant rebound after stopping the first time, just the normal result of less exercise and eating out more often.
I think your rational for using it makes the most sense for us; towards the end of a diet when you need to drop those last few pounds to really shred up.
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please post a physique pic.
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Care to look over my log and give some pointers? Curious what advice you have for someone in my position.
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Stop
Good point. Antidepressants that I crease serotonin usually make the patient gain weight, SSRIs don’t. Why? Because they make one nauseous. It’s a well known effect.
The glutides are GLP-1 receptor agonists, GLP-1 is what is called an Incretin. GIP is another incretin that the body produces. Incretins got their name from the incretin effect. This effect can be seen when you ingest 100g glucose orally vs injecting 100g of glucose into a large vein and the body in response is producing more insulin when the glucose is ingested orally. The reason for that is that cells of the gut produce GIP and GLP-1. These act on the GLP-1 receptor at the pancreas and heighten the sensitivity of the pancreas cells for sugar. When the pancreas then senses sugar in the blood stream, it releases more insulin compared to without GLP-1-R agonists.
Two things you can learn from that.
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With GLP-1-R agonists, the pancreas still only produces insulin when glucose is present which explains why there is no increase in rate of hypoglycemia with GLP-1-R agonists.
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It does not make the pancreas work full time like sulphonylureas do and therefore does not lead to secondary failure after a few years of use. It does overstimulate the pancreas enough to cause pancreatitis in some patients, though.
The reason for these drugs to decrease hunger is because GLP-1 decreases hunger directly, peripherally but also in the CNS (it’s a peptide yes, but some areas of the CNS are outside the blood brain barrier, for instance the region responsible for the initiation of vomiting).
Here’s a review if someone’s interested. There are likely newer ones, but this one ain’t bad.
“It delays gastric emptying and gut motility in humans. In addition, interventricular injections of GLP-1 inhibit food intake, independent of the presence of food in the stomach or gastric emptying.”
“suppression of food intake after peripheral administration of the GLP-1 receptor agonists exendin-4 and liraglutide is mediated by activation of GLP-1R expressed on vagal afferents as well as direct CNS GLP-1R activation”
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The drugs make the patient piss out glucose, that’s the reason why these patients often suffer from candida infections as well. Now the problem with Type 2 diabetics is that they usually have clogged arteries and neuropathy, both leading to a bad immune response and slow healing of wounds. This is worst at the extremities.
Gangrene of this type is cause by a standard bacterium called Streptococcus pyogenes. Sometimes the media calls it “killer bacterium” or “meat eating bacterium” while most parents call the disease it most commonly causes “Scarlet fever”.
Streptococcus of this type often infects catheters of immune suppressed people, including diabetics that have a bladder catheter. I guess it’s only logical that these types of people would then also be prone to this type of UTI. I suppose, this does not affect healthy people in the same way or in similar proportions. Just like covid does not kill healthy people in any serious proportions, so do most common pathogens. It would thus not be the same for a gym rat taking these drugs (though I don’t see a reason why I ever would, because of all the points outlined by others already).
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I found this out the hard way, I ate a large meal then injected 1mg of Liraglutide and went hypo in about 20 minutes. 1000 cal to reverse it. Always take the shot BEFORE eating lol