My follow-up with my provider today went really well!
TL;DR
- Lowering T prescription from 200mg/week to 180/week (which is pretty much what @jackolee was thinking; I have been taking 260, though, so wonder if 180 is too significant of an immediate drop and if I should go slightly higher for the time being?)
- Switching from 2X/week injections to 3X/week
- Aiming to lower estrogen by increasing Danazol dosage (hoping for insights on how much I should increase it) @traveling-man
- Need to continue monitoring T3 and increase caloric consumption
More Detail
I was pleasantly surprised to find my provider wasn’t overly concerned about the high numbers. We did decide to lower my dose from 200/week to 180/week. We also decided I will inject 3X/week instead of 2X, which should keep estrogen more steady.
Right now, my Free T is 54.3 (using the decimal-point conversion system), and we are hoping to see it around 40 next time around. We are also hoping to see SHBG go down more and E go down.
Our meeting largely focused on estrogen — he thinks the high E, which is likely a result of the high T dose, is what is throwing off my sleep. I simply have too much energy. I definitely feel this during the day; I’ve been insanely driven since switching to injections. He also is confident the high E is what is throwing off my libido, given my low prolactin. He says our goal is to get the E number to be lower than the SHBG number.
He gave me the flexibility to decide how much to increase my Danazol dosage and was happy to go up to 25 mg ED (previously: 25 mg EOD). I’m hoping for some insight here. I was thinking I would do 25 mg 5X/week. My goal is to get SHBG under 50 (was 72 on these recent bloods after starting at 180 at the beginning of HOT). How much would you increase it? Would you go up to 25 mg ED? I don’t want to overcorrect, plus there’s the convenience factor of paying for/ordering more meds.
It seems Danazol will intermittently be a part of my protocol for the foreseeable future. Once we get SHBG sufficiently low — which will allow me to have a more moderate T level — we will lay off the Danazol for a while, then reintroduce it if SHBG increases too much. This cycling system will be in place to reduce the risk of liver toxicity.
We also talked a lot about my high Reverse T3. My doc believes this is a result eating too few calories — something he sees a lot in bodybuilders who do caloric restriction for show prep (@bmbrady77).
He believes I should be eating a lot more, which I know won’t surprise some folks around here (@The_Myth)! He even said I should be eating twice as much (~3500 cals), though that seems extreme to me and I definitely don’t plan to jump up there. Currently, my T3 is 9% of my Reverse T3, and our goal is for it to be 20% or more. But raising thyroid hormones can also raise SHBG, so we are going to leave this alone for now and just roll with the other changes I outlined above. We’ll continue monitoring.
Final note: he didn’t think I necessarily needed more bloodwork now (as opposed to in 6 weeks), but I asked for it. So, I will have a CBC and CMP in the next week. As I understand it, these tests should include HCT, HGB, and RBC, among other biomarkers.
He wasn’t super concerned about HCT because my level has been stable throughout treatment on the four tests I’ve had (45, 46.6, 44, 45.7). But it will be interesting to see how much it has jumped up, given the rise in Free T.