I’ve been taking 60mg daily of prenenolone since I started HRT a couple of months ago. Searching the subject online and in these threads gives me alot of conflicting information.
I’d like to get your opinions. 60mgs seems high from what I read. Is it essential while on HRT. I’m on t, hcg and adex.
Did your TRT doctor recommend it? If so, you should ask him or her why.
The main problem with taking pregnenolone as a supplement is that it is impossible to know which hormones will be stimulated by it. There is a pathway from pregnenolone to DHEA to estradiol via the 5-alpha reductase enzyme, so that is a possible problem.
Linolenic acid is a 5-alpha reductase inhibitor so I would think adding it to your supplement regimen would make sense if you continue the pregnenolone.
Daily doses run anywhere from 25mg to 600mg a day depending on why it is being taken. LEF recommends 100mg a day as a supplement, so I wouldn’t think that 60mg a day is excessive.
I’d love to read a scholarly argument calling it an essential part of a TRT program. Most anti-aging guys recommend it for its memory enhancing properties.
It wasn’t doctor prescribed. The hrt clinic had sent it with my scripts. I don’t see a need for it and quit taking it. Also, I had a constant headache that went away within a couple days of stopping the pregnenolone.
My TRT doctor prescribes transdermal pregnenolone. What KSman says is true. I don’t off hand how many mg I’m getting through the skin, but I know I feel much better when I take it.
Maybe my body needs it, but yours doesn’t. Shouldn’t take it without a clinically proven reason, in my opinion. It could be your dose was too high for you.
pregnenolone is the first step after cholesterol on the way to steroid hormones. The production of steroid hormones is controlled by pituitary hormone releasing peptide hormones [protein based]. Restoring pregnenolone hormones will not lead to uncontrolled production of hormones.
Read this and check out the diagrams:
Note the enzymes in the second diagram. Conversion of one steriod into another is never spontaneous.
And taking DHEA will not increase T unless one’s DHEA was low and limiting ones T production AND one’s HPTA is otherwise functional. DHEA is often low because the HPTA is not providing enough HL to maintain pregnenolone production in the testes, so older guys are in a catch-22.
pregnenolone is the first step after cholesterol on the way to steroid hormones. The production of steroid hormones is controlled by pituitary hormone releasing peptide hormones [protein based]. Restoring pregnenolone hormones will not lead to uncontrolled production of hormones.
Read this and check out the diagrams:
Note the enzymes in the second diagram. Conversion of one steriod into another is never spontaneous.
And taking DHEA will not increase T unless one’s DHEA was low and limiting ones T production AND one’s HPTA is otherwise functional. DHEA is often low because the HPTA is not providing enough HL to maintain pregnenolone production in the testes, so older guys are in a catch-22.