After an extensive / overnight fast the liver dumps glucose into the blood stream to bring it back up as part of the body’s diurnal cycle. This also helps to wake you up in the morning. On the other hand, after only 120 minutes post-meal, insulin has acted to bring your blood sugar down, but the liver hasn’t responded yet to bring it back up.
Hence, morning fasting blood sugar will be somewhat higher than post-meal insulin moderated blood sugar.
Oral Glucose Tolerance Tests are the first study of my PhD thesis, so this may help. I initially found all of my subjects to be normal (like you) based on the glucose data. Unfortunately, once we got the insulin and C-peptide results we found the subjects to be diabetic. Their bodies were pumping out so much insulin that it managed to reduce the glucose to normal. I guess what I’m trying to say is that serum glucose levels really aren’t the whole story. At best it looks like you haven’t had insulin resistance for the past few years of your life.
I’m not trying to bring you down, just don’t want anyne to have a false sense of security.
What was your initial glucose load (ie dosage and volume)?
Loopfit: Now that I have this data, I am going to use it when I implement the next round of massive eating. Possibly use more p+c meals around my training times and post times. BTW, one week on the maintainence/slight hypo calorie diet and I have already dropped to 13% at least by caliper readings.
Barr: I guess the dosage was a standard 50g glucose solution. It was the little orange bottle. So let me get this straight. The average people you tested had normal reactions to glucose tolerance, but that was only because they were secreting massive amounts of insulin.
Can you go more indepth on this because I thought that IRS & Type II DM had to do with the body not being able to successfully reduce BG down to reasonable levels. Even if they become somewhat resistant aren’t there resting levels > 110mg/dl? If there is some syndrom to where BG lvl’s are reduced to normal but with a huge insulin response, then is this some new form of DM? Or am I just way off base here?
The syndrome you are wondering about is the beginning stages of NIDDM, or non-insulin dependent diabetes mellitus. Basically, a patient is adapting to his decreasing ability to process glucose by secreting more and more insulin. Eventually, a breaking point will be reached, and the patient will no longer be able to normalize the glucose levels. This is when we see Type 2 DM rear its ugly head. I think this is what Barr saw in his Phd study. A measured insulin level will reveal whether or not the patient is compensating for insulin resistance in the face of normal glucose findings.
Oh yeah, Baes, I forgot to ask… How did you like the orange glucola solution? BLEEECCCCCHH!!! The cola-flavored kind doesn’t taste any better, though. I had a friend at work here chug two full bottles of the 150g glucose solution on a dare. He turned green, but didn’t puke. I would have chummed like a shark fisherman if I drank two bottles of that stuff!
Loopfit: Probably was 75g and I just made a newbie mistake of drinking something w/o checking all the facts first.
Lothario: Ok, I get the picture; so after repeated super insulin saturations in order to bring BG levels down, Type II DM or IRS develops. Duh, makes sense now.
The best way to describe it would be like drinking liquid ass (that’s what ass must taste like). You would think with it being sugar that it would taste better, but oh well, at least I wasn’t alone.
just out of interest, anyone here done an insulin clamp…?
I figure it would be great especially post workout, you muscles must feel like rock afterwards…
I should have clarified, my subjects are anything but healthy, but diabetes has never been shown in this group before.
A 50g glucose load is appropriate for a 28kg subject during an OGTT.
You guys really don’t like the taste of the drink? Have you tried cola or Lime glucola? My subjects love Lime (basically tastes like Sprite).
Whetu, do you know what an insulin clamp is? I’m not being cynical, I’m sincerely asking. It’s a relatively serious procedure, in that someone can’t just do it themselves.