This has cropped up a couple of times since my T has been increasing on TRT, and gotten downright bad a few times.
I won’t go into details, but sometimes seems to have headed totally in the opposite direction.
I know that’s not saying much, but anything biology-related you guys would look at before psychological stuff?
Very little detail and context in your question.
There’s been days where I’m ready to stand up to our office landlord, and then 2 days later, I feel timid with the checkout person at the store. Lots of fluctuations.
I seemed to do a little better on HCG, but not well enough to stay on it given the side effects it gives me.
Early on with TRT, there was a nice stretch towards the end of the honeymoon period where my confidence not only felt great, but it felt very natural - that’s what’s frustrating. Honeymoon in general reminds me of kids taking too much adderall and thinking that’s how they should feel. But this stretch was noticed by a few others, who said I seemed to be having a great day.
Were you on daily injections I cannot remember?
Maybe you can take some basic blood tests like total testsosterone, estradio, cortisol and prolactine on these consecutive days to observe which hormones fluctuate when you fee shitty
Yup, daily.
Planning to get another TT/FT/E2 test around the end of October to see where I am with this new 200mg weekly dose.
Prolactin I have a new endo lined up to see, as it was high on my last test, but it may not all be bioactive. I know you understand that whole struggle man 
Did you ever try pramipexole? I would try pergolide for its strong D1 agonism, in hopes it’d be less sedating, but apparently it caused heart problems in humans and was taken off the market.
It’s funny I remember confidence being shit when I crashed my E2, and I’ve been adding in CDG lately, which pre-TRT caused issues for me. Gonna drop that too I suppose.
You’re either in the middle of a protocol or your injection frequency is not appropriate. Men who change dosing often will continue to feel unstable indefinitely. I don’t feel functations after 6 weeks on the same dosage.
Every day, and just ramping up to 200mg from 150mg. The confidence has slowly slipped the further along I’ve gotten.
Again it could be psychological, I’ve had a lot going on in my life and I don’t expect TRT to magically fix it all. But some has wavered on its own which is a little odd.
Even if hormone levels are not the cause of your psychological problems, TRT can help you cope with these psychological problems, anyone with low testosterone will have some mental issues to varying degrees.
You just need to find the perfect balance of dosing and injection frequencies that show the best results. You should be prepared and know it may take longer than a year to figure out because it took me 2 years to learn what protocols I do best on.
Yea I know. I refused to believe it at first, but even after 3 months I started feeling a LOT better than I had before (honeymoon period being the exception).
I have noticed I have more control over emotions lately. But there’s also more assertiveness which is challenging to keep in control.
Did you ever try pramipexole?
@bigmistake2 Man, dont touch that…there is not escape from it. Its highly addictive.
Excuse me I dont remember, but have you tried cabergoline? From my research its the safest and most purified dopamine agonist. I take it several months now and I’m trying to increase the dose. I noticed benefits from it so far, but due to my extreme sensitivity I was able to take only a very microscopic dose. Now I try to increase it to put the prolactin not only in range but in optimal values.
I have - remember our conversations about it?
The hardest part right now is the limited number of options I see.
@bigmistake2 I got some memories, but excuse me man, my memory has been in decline the last years.
If caber does not work for you(can you remember me what dosage you tried?) the only other safe dopamine agonist is bromocriptine. And the one you mentioned above is the worst, used for very heavy cases only.
Have you made a consultation with Defy medical? The pay a lot of attention on the prolactin and have very deep knowledge in managing it.
Hey man, all good!
Bromocriptine was a nightmare for me. Caber was remotely tolerable.
I’m gonna wait and see this endo in a few weeks and see where my actual prolactin is. If it’s actually elevated then maybe I’ll try caber again. I wanted to try .25mg/week but it’s so damn hard to split the pills that small. I tried .5mg/week last and it felt like it was sucking the life out of me. I was at a music festival with my girlfriend and some friends and spent a LOT of time in the hotel as a result.
I’m also curious…my grandma takes L-DOPA for Parkinson’s, and my research points to it being more tolerable than the DA’s. I wonder why they don’t try that for prolactinoma? When I was experimenting with mucina puriens, at least I felt better. I should’ve asked Dr Saya during our last consultation, but it’s hard to remember all these things in the moment.
So you could not stick with the caber because of the side effects?
Partially that, and partially because it wasn’t improving my PRL levels
P5P is a good and not-insane way to treat high prolactin. Using DAs to do it is playing with fire. I’d exhaust all other options before messing with those.
I tried P5P…did nothing, verified by blood test
How much did you use and for how long?
P5P? I want to say 50mg/day for 2-3 weeks. It also made me REALLY horny and REALLY angry.
Plain old B6 does the same thing.
The studies I read showed P5P at closer to 200mg is effective for lowering prolactin but like everything else 2-3 weeks isn’t long enough to have much of an impact.