Found this link on another site. Imagine the implications…
http://www.acceleronpharma.com/content/products/ace-031.jsp
I’d post my thoughts but T-Nation is devouring all my posts today. Once bitten and all that…
That would be epic. I would totally take that if at some point I wanted to be Ronnie Coleman size.
Can’t wait.
That would be amazing, if their just starting clinical trials thought…could be a bit of a wait.
Good thing I got a few years yet.
thanks but this is years old - try searching for myostatin…
I wonder if there is any negative feedback from using such drugs. This would create an environment post-cycle in which it would be impossible to retain muscle mass. Not sure if that’s something most people would want to mess around with, especially since there is likely an interconnected network of other substances in the body (think HPTA function).
I find it a bit contradictory that the people on this site would be for such a drug.
One pill, few side effects, and little to no work involved and poof you have the musculature of that bull.
What’s the point? If it becomes that easy for ANYBODY to gain muscle, there will be nothing left to set people like ourselves apart from your everyday lazy American.
This is the type of issue that really combines ethics with drug use.
[quote]tedro wrote:
I find it a bit contradictory that the people on this site would be for such a drug.
One pill, few side effects, and little to no work involved and poof you have the musculature of that bull.
What’s the point? If it becomes that easy for ANYBODY to gain muscle, there will be nothing left to set people like ourselves apart from your everyday lazy American.
This is the type of issue that really combines ethics with drug use.[/quote]
Yeah, the Guidos would really think they’re hot shit then.
The lack of physical or mental effort necessary to be muscular and lean would certainly lead to a revolution of what being muscular means, or at least what sort of image it portrays to others. However, the drug doesn’t inhibit myostatin expression, it only acts as a receptor competitor. I guess a person could take a TON of it to have the myostatin gene inhibition results, but it would likely not lead to wildly unnatural muscle mass as many people probably imagine.
The mechanism of action would also suggest a method of negative feedback regulation, so unless use was perpetual, and potentially increasingly dosed, the muscle mass would be very transient. Just my thoughts, but I don’t think it’ll be the holy grail as most would think.
[quote]tedro wrote:
I find it a bit contradictory that the people on this site would be for such a drug.
One pill, few side effects, and little to no work involved and poof you have the musculature of that bull.
What’s the point? If it becomes that easy for ANYBODY to gain muscle, there will be nothing left to set people like ourselves apart from your everyday lazy American.
This is the type of issue that really combines ethics with drug use.[/quote]
You thought sort of mirrors the one I was too afraid to post in the wake of yesterdays great T-Nation technical chaos.
I would kind of hope this drug doesn’t ever end up coming out, just because, if it works as intended, then being a big guy that put in the years and years of effort and study to get where he was would no longer be seen as anything special. Can you imagine some of the guys that come on this site having access to it?
However, miracle drugs are usually just myths and rumor. There are very, very few that ever actually come to be.
EDIT
Schwarz, your post wasn’t up when I posted. Looks like you said what I was thinking, but in a much more elegantly technical and well spoken way, thanks.
Nice posts tedro, cortes, schwarzy. I do agree. But come on, I’d like to experiment too :). That’s why I’m a biochem geek. When it comes down to it though, I don’t see this being the killer miracle we might fear it being. Too many things going on, and there’s a world of difference between conserving mass and becoming a freaky big dude.
Howdy,
Check out a drug named MYO-029. Stage 2 trials ended sometime in January 08 I think. Wyeth pharmaceuticals did randomized studies with MS sufferers. All of the results have so far been really hush-hush. The rumor on the MS boards is that the studies have been submitted to JAMA (or the “Journal”)for peer review. Some of the few people who have stepped forward as trial participants, have had mixed reviews. Only 2 that I can find. One has said that he was able to walk (possible troll on Wired). The other has said he felt no noticable effects. Since the study was randomized and double blind (I hope), neither of these people would know if they were recieving the drug.
Sorry for the double post. . .
This class or type of drug brings up many questions that I am curious to see the results of. For one, a drug that can increase muscle mass by claims of 40% (in mice), can’t be good for the body. I would imagine that it would cause a fair amount of stress for all systems.
Speaking of stress, what about the organism’s tendons and ligaments? I can’t imagine that they would be able to build up as fast as the muscle tissue. Obviously this would increase a risk of injury.
MYO-029 is basically a molecule designed to “mop-up” the myostatin in an organism’s system. It mimics the natural receptors on an organism’s body, causing both to link, and then pass from the system. In theory, leaving the body virtually myostation free. The question that arises from this knowledge is: What happens when an organism stops ingesting the drug? Does the equal and opposite effect happen?
Good thread start, man. I find this subject matter to be fascinating. I am eagerly awaiting the results of this study. Drugs like this, if they truly work (with a minimum of side effects), can and will change the face of the lifting world. It’s almost like watching the first steroids being made.
I couldn’t say for certain if I would try this substance. I have not done a cycle yet. I would be curious about that, before thinking about some thing like MYO-029.
Sorry for the long post. I’m kinda a GEEK for this sort of thing.
Peace,
[quote]bushidobadboy wrote:
Nice info D3HT09 and some valid points about tendon health, etc.
I’m also wondering whether the myostatin block would affect cardiac muscle and smooth muscle. If so, them cardiomegally and intestinomegally (is that a word?) will be on the menu.
But christ, can you imagine what might be achieved in say 6 months by an advanced lifter with a spot on diet, steroids, insulin, GH, IGF1 and a myostatin blocker…?!? Potentially quite frightening. Or exciting, depending on which way you view it 
Bushy[/quote]
My thoughts exactly. Experience would dictate the level. Yes you could develop muscles and loose the fat, but that still doesn’t mean you would be the biggest, baddest, most symmetrical individual.
Plus the cardiac and intestinal effects are yet to be seen. I don’t count my fingers on that drug reaching its intended goal. I am far more worried at the implications of the human genome project. Why develop a drug, when they can alter the genetic make-up of your future generations???
Something to think about:(
I want to look like that cow
[quote]bushidobadboy wrote:
I’m also wondering whether the myostatin block would affect cardiac muscle and smooth muscle. If so, them cardiomegally and intestinomegally (is that a word?) will be on the menu.
But christ, can you imagine what might be achieved in say 6 months by an advanced lifter with a spot on diet, steroids, insulin, GH, IGF1 and a myostatin blocker…?!? Potentially quite frightning. Or exciting, depending on which way you view it
Bushy[/quote]
Good Points. I think that an entirely new level of build could
potentially be achieved with this type of drug. I am currently checking other MS sites and boards to see what the latest is on these studies. When you really think about it, these unfortunate people will be on the forefront of new tech like this. The only way that I see new meds like this being developed, and subsequently pushed through, would be for muscle wasting diseases. Here in the states, the FDA does not seem to give a damn about lifters, or anyone truly interested in better health. FDA only seems to be interested in helping those who are already suffering with disease.
MS sufferers (and also AIDS/ HIV sufferers, etc.), are in a way, kindred spirits. We all have the same goal of muscle hypertrophy. Unfortunately, lifters are still under a stigma in society, for some to consider freaks of nature (I would like to be MORE of a freak, my self). As lifters, we cannot still get access (legally)to many of the training aids available. I am hoping that studies on medications will continue to run, and be pushed through, for the benefit of those who will need it to survive. I will be waiting for the inevitable “Trickle Down Effect”, some time later.
I will be watching MYO-029, with rapt anticipation. If I find anything good out there for info, I will place it into this thread. Lots of potential for amazing stuff here. . .
On a separate note, if there are currently any MS sufferers, etc on this board, please speak up. I have seen some people on the MS boards making suggestions to look at the lifting boards (as we are also experienced in alternative means for muscle hypertrophy). I think that we could have a lot in common here. I will also make some suggestions on the MS boards as well. Maybe we could get some entirely different info from the “other side of the hypertrophy coin”. Something to think about.
Peace,