Anyone have any experiance with myostatin blockers. Atomic dogs latest article mentioned them, but now looking around it seems they’ve been around a while and never caught on. scam???
Biotest made one, and everyone here seems to have so much faith in Biotest, did they just make a mistake???
ive been wondering this same thing
Actualy, Biotest ran a myostatin product for a while,a long time ago, but it didn’t pan out as hoped.
Not that it can’t be done, but gene manipulation a that level is very tricky, and may not reach the public for a long time.
Here is some info I found:
Myostatin is a gene that limits muscle growth. This protein is a member of a superfamily of molecules called transforming growth factors beta (TGF-b). It is also called growth and differentiation factor 8 (GDF-8). Scientists have discovered that a mutation in the myostatin gene is responsible for increased muscle mass, also known as ‘double muscling’, in animals. A mutation in this gene has similarly been found to account for unusually large muscle mass in humans. Scientists hope that myostatin inhibitors may be able to treat diseases such as muscular dystrophy, which waste human muscle. In addition, there is some concern about the possibility of abuse of myostatin inhibitors by athletes.
Myostatin (formerly known as Growth and Differentiation Factor 8) is a growth factor that limits muscle tissue growth, i.e. higher concentrations of myostatin in the body cause the individual to have less developed muscles. The myostatin protein is produced in skeletal muscle cells, circulates in the blood and acts on muscle tissue, apparently by slowing down the development of muscle stem cells. The precise mechanism remains unknown.
Myostatin and the associated gene were discovered in 1997 by geneticists McPherron and Se-Jin Lee, who also produced a strain of mutant mice that lack the gene and are about twice as strong as normal mice. The gene has been sequenced in humans, mice, zebrafish and several other animals, showing few differences among species. Lee found in 1997 that the strong Belgian Blue and Piedmontese cattle strains have a defective myostatin gene; these strains have been produced through breeding.
In 2001, Lee created mice with intact myostatin gene and large muscle mass by inserting mutations that boosted the production of various myostatin blocking substances.
In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother, a former sprinter, has a mutation in one copy of the gene.
Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy. The idea is to introduce substances that block myostatin. In 2002, researchers at the University of Pennsylvania showed that monoclonal antibody specific to myostatin improves the condition of mice with muscular dystrophy, presumably by blocking myostatin’s action.
In 2005, Lee showed that a two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%). It is thought that binding of myostatin to the soluble activin receptor prevents it from interacting with the cell-bound receptors.
It remains unclear whether long term treatment of muscular dystropy with myostatin inhibitors is beneficial: the depletion of muscle stem cells could worsen the disease later on.
As of 2005, no myostatin inhibiting drugs for humans are on the market, but an antibody genetically engineered to neutralize myostatin was developed by New Jersey pharmaceutical company Wyeth. The inhibor is called MYO-029 and is currently undergoing human testing[1]. Some athletes, eager to get their hands on such drugs, turn to the internet, where fake “myostatin blockers” are being sold.
Myostatin is a member of the TGF-beta superfamily of proteins. Human Myostatin consists of two identical subunits, each consisting of 110 amino acid residues. Its total molecular weight is 25.0 kDa. It can be produced in genetically engineered E. coli and is available for sale. Johns Hopkins University owns the patents on myostatin.
( Answers - The Most Trusted Place for Answering Life's Questions )
They tried MyoStat CSP3 a few years back, but it just didn’t live up to the expectations. Only time will tell if they ever find a way to improve on their original ideas…
As the last poster saider, gene therapy is complicated stuff especially when you’re talking about an oral supplement.
[quote]CC wrote:
They tried MyoStat CSP3 a few years back, but it just didn’t live up to the expectations. Only time will tell if they ever find a way to improve on their original ideas…
As the last poster saider, gene therapy is complicated stuff especially when you’re talking about an oral supplement.[/quote]
Dumb question, but are there any foods or things that are on the market that cause a downregulation of mystatin production?
Stay tuned, when Biotest releases " Anaconda", you may have your answer.
Yes, they have been teasing us with ‘Anaconda’ for some time now.
[quote]scotty144 wrote:
Yes, they have been teasing us with ‘Anaconda’ for some time now.[/quote]
Could this be Biotest’s first injectable to date?
[quote]itsthetimman wrote:
scotty144 wrote:
Yes, they have been teasing us with ‘Anaconda’ for some time now.
Could this be Biotest’s first injectable to date?[/quote]
no
[quote]BarneyFife wrote:
Dumb question, but are there any foods or things that are on the market that cause a downregulation of mystatin production?[/quote]
Think about it, if Biotest’s CSP3 couldn’t bind the myostatin protien effectively, what possible food out there can do it? There probably are food that contains properties that can exert this kind of effect, but how much would you have to eat? I say don’t even waste your time.
It was such great idea to cancel out the protien instead of manipulate the gene, too bad it didn’t pan out.
[quote]SLERG wrote:
Stay tuned, when Biotest releases " Anaconda", you may have your answer.[/quote]
So, is Anaconda going to have something to do with myostatin?
Or are you just speculating?
[quote]T Ham wrote:
SLERG wrote:
Stay tuned, when Biotest releases " Anaconda", you may have your answer.
So, is Anaconda going to have something to do with myostatin?
Or are you just speculating?[/quote]
Anaconda is not designed to do this.
http://www.T-Nation.com/readTopic.do?id=462004
http://www.T-Nation.com/readTopic.do?id=461393
http://www.T-Nation.com/readTopic.do?id=824825&pageNo=0
tim’s most recent comments on myostat are on the bottom. Your question actually made me curious so I did a bit of research on Biotest’s myostat involvement.
[quote]Mod Brian wrote:
T Ham wrote:
SLERG wrote:
Stay tuned, when Biotest releases " Anaconda", you may have your answer.
So, is Anaconda going to have something to do with myostatin?
Or are you just speculating?
Anaconda is not designed to do this.[/quote]
So what is it designed to do? (worth a shot)
[quote]Reef wrote:
Mod Brian wrote:
T Ham wrote:
SLERG wrote:
Stay tuned, when Biotest releases " Anaconda", you may have your answer.
So, is Anaconda going to have something to do with myostatin?
Or are you just speculating?
Anaconda is not designed to do this.
So what is it designed to do? (worth a shot)[/quote]
I heard that it could save you 15% on your car insurance.
[quote]allNatural wrote:
itsthetimman wrote:
scotty144 wrote:
Yes, they have been teasing us with ‘Anaconda’ for some time now.
Could this be Biotest’s first injectable to date?
no[/quote]
dude, comeon, obviously it was a joke…lame
You can still buy MyoStat if you look hard enough. I heard about the product and researched it on the web and eventually ran into a few sites still selling it.
As far as Anaconda goes, the ONLY people that have given any information out as to what it is are the forum posters. To the best of my knowledge TC said something like “A new supp to revil mag10 gains” and everyone started throwing out their own ideas.
I really think that this Myostatin issue is a potential goldmine for anyone that can make it work, not only for the bodybuilding people, but for people with any type of need for an increase in muscle mass will benefit as well.
Its my guess that whoever does solve it, will have to deal with the drug companies and all of that BS anyways. As far as Anaconda goes, its going to be real hard to create a muscle building product without being able to manipulate steroid molecules, and at the same time keep it “legit”, with government.
[quote]SLERG wrote:
I really think that this Myostatin issue is a potential goldmine for anyone that can make it work, not only for the bodybuilding people, but for people with any type of need for an increase in muscle mass will benefit as well.[/quote]
Ha, ya think?!
People have been scrambling to unlock the secrets to manipulating this gene ever since it was discovered. So far, whoever developed this AVCR2B seem to be the only ones who have even come close. That stuff (ACVR2B) has been in the trial stages for awhile now; this isn’t the first time it’s been mentioned around here: