I was actually going to post this because I misread lipogenesis as lipolysis and was confused by the authors conclusion. It makes much more sense when read correctly.
Consuming Fructose-sweetened Beverages Increases Body Adiposity in Mice
Hella J?rgens*, Wiltrud Haass*, Tamara R. Casta?eda, Annette Sch?rmann, Corinna Koebnick, Frank Dombrowski, B?rbel Otto?, Andrea R. Nawrocki**, Philipp E. Scherer**, Jochen Spranger, Michael Ristow, Hans-Georg Joost, Peter J. Havel and Matthias H. Tsch?p,
- These authors contributed equally to this work.
German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany;
Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio;
Department of Pathology, Otto-von-Guericke-University, Magdeburg, Germany;
? Department of Gastroenterology, Innenstadt University Hospital, Munich, Germany;
** Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York;
Charit? University Medicine, Berlin, Germany; and
Department of Nutrition, University of California, Davis, California.
Address correspondence to Hella S. J?rgens, Department of Pharmacology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114?116, 14558 Nuthetal, Germany. E-mail: juergens@mail.dife.de
Objective: The marked increase in the prevalence of obesity in the United States has recently been attributed to the increased fructose consumption. To determine if and how fructose might promote obesity in an animal model, we measured body composition, energy intake, energy expenditure, substrate oxidation, and several endocrine parameters related to energy homeostasis in mice consuming fructose.
Research Methods and Procedures: We compared the effects of ad libitum access to fructose (15% solution in water), sucrose (10%, popular soft drink), and artificial sweetener (0% calories, popular diet soft drink) on adipogenesis and energy metabolism in mice.
Results: Exposure to fructose water increased adiposity, whereas increased fat mass after consumption of soft drinks or diet soft drinks did not reach statistical significance (n = 9 each group). Total intake of energy was unaltered, because mice proportionally reduced their caloric intake from chow. There was a trend toward reduced energy expenditure and increased respiratory quotient, albeit not significant, in the fructose group. Furthermore, fructose produced a hepatic lipid accumulation with a characteristic pericentral pattern.
Discussion: These data are compatible with the conclusion that a high intake of fructose selectively enhances adipogenesis, possibly through a shift of substrate use to lipogenesis.
Key Words: fructose ? soft drink ? energy balance ? energy expenditure ? rodent
This would tend to lend credence to the theory that lots of fructose during the load would tend to fill liver glycogen stores and let you run on that, enhancing fat deposition and encouraging sugar burning.
Now wether this means I would dissaude you from eating fruits entirely, I’m not so sure. I would definitely avoid the HFCS during the load and pretty much all the time forever.
-Conor