Metformin For Cycle Support

Pharma / TRT
1

I have decided to run my first cycle. The plan:

  • Bump my TRT dose of test cyp from 200mg weekly to 300 for 12 weeks

  • 300mg mast per week for 12 weeks

  • 20mg per day of Anavar for 6 weeks.

For support I will be taking:

  • TUDCA / Milk Thistle
  • NAC
  • CoQ10
  • Fish Oil
  • Nattokinase

It’s my understanding that metformin exhibits a protective effect on blood vessels, can drop ldl and increase hdl, decrease blood pressure, decrease systemic inflammation including on the liver and kidneys et cetera, all good things for side effects of the compounds I’ll be using.

I’m also aware metformin can bind to and reduce free testosterone which would be counterintuitive, as well as create a risk for lactic acidosis or enhanced soreness to a lesser degree, which would be terrible given the expected pumps.

Can it be supportive for all the reasons listed or is it more likely to be overpowered by the drugs anyways and just wind up weakening my cycle/presenting side effects?

I’m not looking for extreme change, just chemical help knocking out the last few pounds I want to lose while maintaining or even gaining some muscle in a deficit and want to mitigate as many sides as possible.

Thanks.

2

Pump the Immodium, it (Metformin) will make you poop like the Christmas goose.

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3

Lol, sounds festive

4

Not the advice your looking for but I would up the test 500mg/wk. I think you will be underwhelmed going from 200-300 imo.

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5

My doc wanted me to take it years ago. “It might cause Diarrhea,” he said. Taking the que, I waited until a three day weekend to start. By Monday I could have had a colonoscopy. I flushed them… No pun, OK maybe.

6

Lol, maybe some Metamucil too then

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7

Nevermind. I answered my own question. Not sure why this didn’t pop up on earlier searches. Not with Anavar.

Metformin - LiverTox - NCBI Bookshelf.

8

Goals?

I’m not sure about the Mast, hence the goals question. I guess the other question is where you are right now in terms of fitness.

9

Ultimately dropping down to ~210 and then rebuilding to a PL competitive weight of 225 as a walk around weight, competing at 220. I want to beat some masterclass records in Texas over the next few years.

Short term goal is the weight loss portion while maintaining strength.

I chose both var and mast for this purpose, with the increase in test to allow more estrogen conversion as mast will negate it.

I recently started a log tracking these goals but need to get in the habit of updating it. I’m still torn on metformin, specifically for protective elements it provides in application as a compound for cycle support. There is conflicting research on liver impact.

10

I think that with only 20mg of Anavar you won’t need liver support. The TUDCA is likely more than enough.

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11

Interesting. Do you have reference for this?

12

I’ve found a number of similar studies to this one. Unfortunately, they are all based on diabetic, often obese and generally unhealthy people so it’s hard to say how much crossover there would be.

Interestingly this study shows an increase in free test, but with the same subject pool limitations.

https://onlinelibrary.wiley.com/doi/10.1111/andr.13318#:~:text=During%20the%20treatment%20with%20metformin,in%20SHBG%20or%20total%20testosterone.

More conflicting info, but the larger body of info I’m finding shows a reduction.

13

Thank you, I hope you’re right.

To clarify, I’m primarily interested in cardio protective aspects of metformin given the mast, but not at the expense taxing my liver beyond anavar’s impact, and as I saw that metformin could stress the liver my concern would be a potential compounding effect.

Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK‐dependent mechanisms - PMC.

14

I misunderstood, my bad.

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