Mental symptoms taking a long time to resolve?

I suffered from low T for several years and have been on TRT for 7 months now. My biggest symptoms were fatigue, low mood and severe brain fog.

I’ve been trying to get dialed in, changing my dose or frequency every 6-8 weeks to try to find something that works.

Fatigue and low mood have mostly resolved, but the brain fog is persistent.

My latest prescription is 120mg once per week (I tried more frequent dosing before and felt much worse). This puts me around 5-600 at trough.

Has anyone had taken a long time (many months) to fix their brain fog? I keep reading about people seeing relief in only a few weeks and it seems so different from my experience.

It’s only been 7 months, and you’ve been changing things every 6-8 weeks. You’re not giving yourself any time to actually adjust/adapt to the medicine.

I didn’t have brain fog, but I definitely had damaged cognition, and though it started changing pretty rapidly, it took several months, if not over a year, before I was really thinking like how I used to. And that was while keeping the dosage the same the entire time.

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Interesting, thank you. I had understood that 6-8 weeks was a reasonable amount of time before tweaking the protocol, but I’ll stick with my current dose for longer this time and see what happens.

Disclaimer: These are my experiences and opinions only.

I started out at 120 mg weekly. At the 10 week mark, my free T was double upper “normal” so Provider backed me off to 100 mg weekly (I do 50 mg twice weekly) and that’s where I remain 1 year later.

What @T3hPwnisher said, you have to be both patient and consistent. If labs look good, sometimes it’s the waiting game.

Now, about 1.5 month ago, I did start supplementing with 25 mg DHEA after doing some reading about other TRT protocols and experiences.

I was feeling an odd, very atypical dip in mood that was prolonged and not attributable to much else if anything. General mild depression really.

I’m in the medical field so I don’t often operate on “hunches” (who am I kidding?! We ALL do, frequently!), but 5 weeks later, symptoms resolved and feel very steady despite lots of work/life stressors.

I’m not saying “do what I did”. Quite often people attribute any and ALL feelings/symptoms to their T levels. This may not even be related or loosely so.

I’m hoping you have done a deeper dive on your general health with a medical professional. Best wishes.

Thank you. Yes, I spent years doing dozens of tests before settling on low T as the probable cause of my issues. Everything always came back perfect, except T.

Nice. Its a Gordian knot sometimes isn’t it. It was a semi-educated guess on my part to try the DHEA and by all measures, seems beneficial.

Again, not saying try the same, but it has premise. I’m sure you’ll get plenty more experienced recommendations here.