The Caffeine in coffee is also a thermogenic and a neural potentiator, hence high levels of caffeine are termed doping by the IOC.
Coffee has also been implicated in reducing bone density, and reducing heart disease.
It reduces insulin sensitivity too, which possibly negates its efficacy as a weight-loss aid with carb-based diets.
Coffee is also cool with a muffin, and if I feed my ex-girlfriend enough she gets really “happy”, “hyperactive” and “playful”, and if I give her a whole lot, she will even start to vibrate.