Josht9210's TRT Log - Depersonalization, Panic Disorder, Agoraphobia, Etc

Fabulous . Looks like the body couldn’t handle the ester or the other ingredients of the T. After all it’s bio identical, but not made by the body. Maybe one day they will Figure out why and we can just sum it up to a side effect of injections .)

I’ll give coming off a test run, perhaps talk to my doctors about my psychological issues and give things another try.

I came off, worse decision of my life. If you think what you’ve been going through now is bad, you could end up in hell. I do not exaggerate when I say I have PTSD from coming off of test cold-turkey. My nervous system was shattered, I almost quit my job, my marriage suffered. I was essentially rendered non-functional. I slept maybe 1-2 two hours a night for months, panic attacks multiple times a day, constant high heart rate, OCD manifested in nightmarish ways I didn’t think were possible.

Find another way man, it’s not worth it. My nervous system is still recovering and I came off in February 2018.

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It takes time for the cream to work. You have built up injections and you need to be patient. Allow yourself 3-4 weeks to let most of the injections out your system and keep using the cream.

Try the cream and hopefully it works for you like it did JP above. I was the one who suggested it to him and I’m hoping it works for you, but it doesn’t happen day1 . You have to let the other T out Of the system.

Keep taking the other stuff it does help whether you feel it or not.

You really need to speak to a doctor like Eric Serrano or an expert in holistic natural health like anthony llabres . That’s who I’d go to and they will look at your situation in a way nobody here can.

I just don’t get how T can make you so bar shit craxy after using it for so long. Not a Stab at you, but I just don’t get it because it’s not having that mechanism. Yes aggressiveness and people can get real angry on it, but that person already has rage and anger issues for it to happen.

Let me add.

The cream is so much better because you can take 2 clicks in the morning and by the next day majority of it’s left your system. This means you can switch to 1 click or 3 on the fly if you have issues.

Usually someone with your issues will want to stay on a min of 1 click am of 50mg per click and start there. After 2-3 weeks your issues should be much less or hopefully gone. If it’s going good you take 1 more click in am or add one to the night time.

Make sure you are using good quality cream. If it’s not from a reputable pharmacy you can have issues. You want to find one that tests it’s batches. Empower does not, but MedQuest does. It’s worth the switch. Empower usually has good cream, but that one bottle that doesn’t work makes for hell until you figure out what’s wrong.

Hang in there man. This has helped many guys. I can’t tell you how many emails and messages I’ve gotten from guys that experienced anxiety on injections. They all switched to the cream and all but one succeeded. The one who did not was taking an ai . When he got off the ai he was able to live life without anxiety.

I have no clue why t has affected me this way, I’m not an angry or violent person, very shy and timid. However I do know t majorly affects the amygdala which is the fight or flight part of the brain which clearly I have a malfunction of. Also seem to have issues with my hypothalamus. Theres more to messing with hormones than meets the eyes, definitely effects many processes in the brain.

As for the cream, I may just back off of everything for a bit to see how I feel.

Thanks for the kind words.

No, we don’t know that. Thats discussed very controversially in the scientific literature. For example re-evaluation of the NHANES III data using the CDCs standardized method revealed a mean T level of young, lean and healthy men of 624 ng/dL Samples were taken between 1988 - 1991 and that’s 3 decades ago. Essentially the same mean T level of the same group of men is measured nowadays - so this data suggests no decline in T levels happened within the last 3 decades.

The 25th percentile of young, lean and healthy men in 1990 was 516 and the 75th percentile was 751 ng/dL. If he brings his levels to 600 to 800 that corresponds to being in the upper part of the population with regards to T compared to young, lean and healthy men 3 decades ago.

We are still very early into the science of what’s causing different emotional/behavioral states. One interesting theory how T potentially impacts emotion is by interfering with the synthesis of neuroactive steroids. Basically T either directly modulates GABA receptor activation or it modulates synthesis of other neurosteroids which in turn modulates GABA receptor activation. There is some good data that demonstrates that GABA receptor modulation is at the center of the so called steroid rage type of behavior.
Some people just seem to be very sensitive to T messing with these neurosteroid pathways.

Essentially the only way to limit this effect is to reduce the T dose.

A maybe interesting option for you might be myo inositol. In the 90s a number of studies were done to investigate into the potential application of this substance for the treatment of anxiety disorders, ocd and depression. Essentially a couple grams of inositol were as effective as eg fluoxetine (an SSRI) and superior to placebo. Maybe worth a try.

I’m glad you chimes in. I was thinking the same on the first part but you always say it better :slight_smile:

I have done tons of research of its effects on gaba, it only seems to promote it in certain parts of the brain, specifically the bnsf. I have tried to keep my neurosteroids in balance via prenenolone, hcg etc. My levels are almost my natty levels with 80mg per week.

Just because someone says it better doesn’t make it true.

He’s an intelligent man and he puts allot of thought into this.

The world is a toxic place and men’s hormones have been dropping at an alarming rate for decades.

When I was 20 something I had labs taken and my total t was 1k plus. I was 23? I am trying to hunt down that doctor and get my records released. When I do it will be shared here.

There is a reason why the total lab range max was 1500 and it’s been dropping since then.

To say we don’t know is like saying trump is a gentlemen and a scholar and we could learn how to treat woman by watching him.

You clearly aren’t reading the studies he’s posted where they go into detail about basically recalibrating different labs equipment to now work off of the same standard.

It’s like if the length of what we call an inch has been changed to put everyone on the same standard. Remeasure old results with a “new” ruler and numerically it will be different but that doesn’t mean something is actually longer or shorter. Same thing here. Different standard for how to measure samples will give a different result and need a new range to match up with it.

If you measured a sample 20 years ago and it said TT was 1200 then you measure the exact same sample today with recalibrated equipment and it says TT is 900, that doesn’t mean TT has actually decreased, obviously. It’s all about how the measurements are done

That’s not to say there hasn’t been some decline and that isn’t to say EDC’s aren’t a real issue. I think it’s a combination of all of these things in reality but it’s getting old hearing the same ol Nichols doctrine in every post.

If what @johann77 has posted is wrong then prove it. Show something that refutes what he’s saying beyond the same ol

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I spoke to a man who is an expert in analyzing these studies . He teaches And has spent his career creating studies and deciphering studies. He is a hormone doctor. When he heard what he said he laughed and said that just doesn’t make sense. He didn’t even give it much thought and carried on. He has read every single study on TRT (humanly possible) and knows exactly what the cited study was. I’ll trust his words not some forum guru who has not clarified his qualifications.

When I posted his response everyone went with the guy above. Why? Who the hell knows.

Continue believing that 6bg/dL in 2009 is now 3ng/dL in 2020. I’ll listen to the experts not just someone who speaks and Writes well.

That’s like saying today a gallon of gas is a little bit less but it’s still a gallon. Because we are having better equipment.

A measurement is just that. It doesn’t change. The only thing that changes is how much can be measured. So if it’s more accurate and 10 ng/dL is measured in 2019, that same vial might be measured again and it shows 8. But 10 is not 8.

How does that matter when we know for a fact that we see being harmed by toxins and other shit in the world today. The endocrine society said so on their site. Books are being written and it’s obvious more and more men have this low hormone issue.

No normal is not 600. What’s normal is what removes symptoms.

https://www.karger.com/Article/Fulltext/339123

I used to teach biochemistry and genetic classes at the university, so lets try together to solve this puzzle for you. Just be open minded.

Lets take the example from the below link. Its T3, but its representative for T or E2 or any other analyte.

Take a look at the graph (D). You see T3 levels on the x axis (mean and standard deviation) and different assays at the y axis. The exact same samples were measured with 12 different assays (A to M).

Compare for example the results from assay K with the results from assay N. Both assays have compare precision (comparable standard deviation) but results of assay K are on average 25% higher than results from assay N.

Question of the day: How can the results be so different?

You may find the video helpful to answer the question

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