I actually have McCardle’s disease that MSM listed under the Genetic Causes. I have had some serious bouts in the hospital before I knew what it was and how it affected me.
After numerous tests the doctors told me to quit working out or doing anything active as it can cause deterioration of the muscle which would ultimately lead to rhabdomyalasys.
I’ve since been back in the gym with great results… I can’t do anything high rep however. My point is that although the doctors are great… they still don’t always know what they are talking about. I’m doing fine and hopefully with any luck your son’s dad will recover partially or fully. Wish you the best.
[quote]MsM wrote:
Makavali wrote:
Otep wrote:
I wonder-
If it’s possible for crazy random shit to happen to us and totally screw up life, is there a flip-side? Can wonders and miracles come right out of the blue, smack you in the face and yell ‘I’m HERE!’
It happens. And when it does - it’s great.
It sure does!
Thank you, Nate.
After not receiving any updates yet, I began to do my own research in an effort to understand this condition better. Much to my surprise, it is not just compression of an area that can cause rhabdomyolysis.
In fact, anything which causes ATP depletion can contribute. Muscle exertion is one of the most common causes. From what I’ve seen, it is mostly an occurrence with marathon runners but I could see this being a possibility for a population of weight lifters on this site too (the powerlifters come to mind). Based on how many people here haven’t heard of that, I’ll say that I think those risks are minimal but just so you know, it’s a possibility.
Other causes:
Medications and Toxic Substances That Increase the Risk of Rhabdomyolysis
Direct myotoxicity
HMG-CoA reductase inhibitors, especially in combination with fibrate-derived lipid-lowering agents such as niacin (nicotinic acid; Nicolar)
Cyclosporine (Sandimmune)
Itraconazole (Sporanox)
Erythromycin
Colchicine
Zidovudine (Retrovir)
Corticosteroids
Indirect muscle damage
Alcohol
Central nervous system depressants
Cocaine
Amphetamine
Ecstasy (MDMA)
LSD
Neuromuscular blocking agents
Traumatic, Heat-Related, Ischemic and Exertional Causes of Rhabdomyolysis
Traumatic causes
Lightning strike
Immobilization
Extensive third-degree burn
Crush injury
Heat-related causes
Heatstroke
Malignant hyperthermia
Neuroleptic malignant syndrome
Ischemic causes
Ischemic limb injury
Exertional causes
Marathon running
Physical overexertion in untrained athletes
Pathologic muscle exertion
Heat dissipation impairment
Physical overexertion in persons with sickle cell disease
Infectious, Inflammatory, Metabolic and Endocrinologic Causes of Rhabdomyolysis
Infectious causes
Viruses: influenza virus B, parainfluenza virus, adenovirus, coxsackievirus, echovirus, herpes simplex virus, cytomegalovirus, Epstein-Barr virus, human immunodeficiency virus
Bacteria: Streptococcus, Salmonella, Legionella, Staphyloccus and Listeria species
Inflammatory causes
Polymyositis
Dermatomyositis
Capillary leak syndrome
Snake bites (mostly in South America, Asia and Africa)
Metabolic and endocrinologic causes
Electrolyte imbalances: hyponatremia, hypernatremia, hypokalemia, hypophosphatemia, hypocalcemia
Hypothyroidism
Thyrotoxicosis
Diabetic ketoacidosis
Nonketotic hyperosmolar syndrome
Genetic Causes of Rhabdomyolysis
Lipid metabolism
Carnitine palmitoyltransferase deficiency
Carnitine deficiency
Short-chain and long-chain acyl-coenzyme A dehydrogenase deficiency
Carbohydrate metabolism
Myophosphorylase deficiency (McArdle’s disease)
Phosphorylase kinase deficiency
Phosphofructokinase deficiency
Phosphoglycerate mutase deficiency
Lactate dehydrogenase deficiency (characteristic elevation of creatine kinase level with normal lactate dehydrogenase level)
Purine metabolism
Myoadenylate deaminase deficiency
Duchenne’s muscular dystrophy
Clinical Features of Rhabdomyolysis
Local features
Muscle pain
Tenderness
Swelling
Bruising
Weakness
Systemic features
Tea-colored urine
Fever
Malaise
Nausea
Emesis
Confusion
Agitation
Delirium
Anuria
Complications of Rhabdomyolysis
Early complications
Hyperkalemia
Hypocalcemia
Hepatic inflammation
Cardiac arrhythmia
Cardiac arrest
Late complications
Acute renal failure
Disseminated intravascular coagulation
Early or late complication
Compartment syndrome
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