Why would there be one? Everyone’s situation is different and even your own life will var. The fast is that “optimal” doesn’t really exist, at least not in terms of a single exact approach being absolutely nailing the PERFECT workout that will stay perfect.
The most you can do is having something that can be, and stay good to very good. And there is actually a range of effective approaches that will fit that category.
And when it comes to hypertrophy, the fact that as long as your sets reach a point where your reps become very hard (slowing down even if you try to push hard). it will work. You can get hypertrophy from 6, 8, 10, 15, 20, 30 and more reps. You can get it with slow eccentrics, normal reps, stato-dynamic reps, loaded stretching, etc.
One thing that I believe in, and that seems to be supported by science, is that using two different approaches is more effective than a single one. And I’d go as far as to say that the more different both methods are (while still being in the effective zone) the more effective it wil be.
For example, when I work with athletes, I use my omni-contraction training system in which the athletes train 3 days a week: day 1 is eccentric emphasis, day 2 is stato-dynamic or isometric emphasis and day 3 is “normal” lifting. That’s three days, not two, but you get the idea.
The most important thing when only training twice a week (or once) is the volume to frequency management.
I’ll say that that higher the frequency is, the lower should the daily volume be. And vice versa. Therefore, when lifting twice per week the daily volume will need to be higher than if you lift 3, 4 or 5 times a week.
But it can become complex to determine the idea daily volume. That is likely the crux of the problem.
Research indicates a weekly volume per muscle of 10 to 20 work sets. So if you are training twice a week, using a whole-body approach, this would come down to 5 to 10 sets per muscle/session. One caveat that makes volume calculation difficult is the fact that many exercises involve more than one muscle group to various levels.
For example, you may classify the bench press as a “chest” exercise. But it also significantly hit the triceps and anterior deltoids. Enough, IMHO, to count a set of bench press as one set for chest, one set for triceps and one set for deltoids.
But some exercises might not be as clear cut… take an horizontal row (seated row or barbell row), they are primarily an upper back exercise with some biceps and brachialis involvement. But not enough for one set of row to count as one set for biceps. But it still counts for something… maybe it takes two sets of rows to count as one set for biceps.
However, the same is not true for vertical pulling (chin-ups, lat pulldowns) which have a higher biceps activation than horizontal rowing (especially if done with a supinated grip). In which case, a set of supinated chin-up or supinated lat pulldown would count as one set for back and once set for biceps.
See how it can quickly become complex.