Im curious, on average, are most guys HCT elevated while on trt and is that normal and have your docs all allowed you to continue without modifying dose etc? Just trying to see how common of a thing this is
Mine actually hasnāt changed since starting and Iāve been on a few months now. Ok, it went up 0.1%. But thatās it for me.
1500 TT and 40 FT
I wish i knew how to convert that to canadian units so i could understand.
Itās over the high end of ānormalā for both by say 25% if that helps at all. Doc said from an HCT perspective I could def handle a higher dose but if Iām feeling better then no need to increase.
So my numbers were even less than yours , tt upper middle range and ft was over by 20% or so yet my rbc and hct was mildly elevated. I wonder if this has anything to do with low shbg? Or is this just the way some guys metabolize the drug and it causes this effect? Another possibility is the frequency of shots was too extreme? I was doing eodā¦just trying to find a reason as to why you are in the clear and im not.
For sure tho if and when i start up again i will resduce dosage instead or 20mg eod perhaps 8 ed subq or shallow imā¦
Talking about studies there are not any studies showing T causes strokes and failure. If anything they have observational studies and studies which draw conclusions based on unhealthy males and they never even discuss the details of the causes. Just that so many men have a x percent increase in rates of death due to cv issues. Read deeper into the study and realize many of these studies are based on men with diabetes or older men 60-70. I saw one observational study based on issue that. Men who had diabetes and these men had more CV events on TRT yet they never acknowledged āprobably not trt and instead their obesity and life styleā.
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Da man and the wizard of hormone lamd
Excellent vid thanks a lot for that. Im going to attempt to show my doc this and hope he wont brush it off or refuse to watch it.
Good luck, but donāt get your hopes up. Confirmational bias at its best.
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Ya, unfortunately, doctors are notorious for that due to their inflated egos and know it all type attitudes.
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Switch doctors. There are plenty to pick from, at least in Ontario.
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Yup what he said!
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If you know any endos/urologists in the GTA (greater toronto area) pls let me know and i will ask for a referral to them
I dont disagree with you, I just want to provide a different perspective.
My personal take is that the risk - if existent at all (!) - is very low. In fact, I actually believe that TRT if done properly protects from cardiovascular events and reduces the overall martality rate in comparison to non treated hypogonadic patients. Thats also the reason why I decided to go on TRT. The risk to benefit ratio just speaks for TRT.
The problem only arises when one wants to provide general guidance for many people as it is the case for drug developers, health agencies or medical societies. In this case the absence of evidence doesnt not mean that there is evidence for the absence. Its purely a question of the level of evidence. Science is pretty strict when it comes to the unambigous demonstration of evidence thats shows no association.
There is quite a big dispute between experts whether TRT is associated with an increased risk or not; the data is just controversial, its ambiguous.
I did a PhD in biochemistry, a postdoc in molecular medicine and have >15 years experience in R&D and drug discovery, but I dont feel qualified to judge or discredit the work done by experts in this field.
The latest review article published in Nature Cardiology, one of the highest ranking journals in this area, concludes (its not freely available):
'Key points
ā¢Population studies suggest that low serum levels of endogenous testosterone are a risk factor for cardiovascular events, although these studies cannot establish causality or exclude reverse causality, and some of these associations might result from residual confounding.
ā¢Although many retrospective studies show no association, some retrospective studies of prescription databases have shown a higher risk of cardiovascular events in men receiving testosterone, with the risk increasing early after treatment initiation.
ā¢Meta-analyses of randomized, controlled trials of testosterone replacement therapy report conflicting findings, probably because the included trials lacked power or the duration was too short to assess cardiovascular events.
ā¢The TRAVERSE trial, the first trial of testosterone therapy that is adequately powered to assess cardiovascular events, began in 2018, and its findings might take a decade to become available.
ā¢Until the results of the TRAVERSE trial are available, clinicians should individualize testosterone treatment after having an informed discussion with their patients about the risks and benefits of testosterone replacement therapy.ā
For me its all about transparency, scientific rigour and discussing data in a non-biased way.
Its perfectly fair to make statements like āIn my personal opinionā¦ā or āMy interpretation isā¦ā but some people here just blast out statements like āTRT does not have any risksā¦ā or ālong term TRT does not havy any impact for fertilityā¦ā.
The arguments brought foward make sense although also here some studies demonstrated a lower incidence of thrombotic events of people living at high altitudes and some show higher rates. Again itās ambiguous.
By the way, Dr Rouzier didnāt publish a single article in a peer reviewed scientific/medical journal. He is not actively involved in any medical research about TRT whatsoever.
Yeah, he is not employed by a university or in cahoots with a pharmaceutical company. Besides, he is too busy to do research. He has, however, read a lot of research papers and disseminates the information to many doctors.
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What would you recommend hcg and Novla at what dose?