You have just repeated my statement and it’s not the answer to my question. I wanted to know the exact reason why one person with high SHBG is entirely asymthomatic and others with the same lab results are suicidal. I even tested my CAG repeats and they are normal (21) but Im still hypogonadal with all of the psyhiatric symptomps without exogoneus test (anxiety, depression, panic attacs)
So you are asking my why one guy with crappy free t feels normal and other terrible?
My brother for example has lower t than Ive ever had but feels much better than me pre trt especially emotionally and psychologically. He considers TRt in the future but no need for now.
Everyone needs different amount of free testosterone to feel good - energy, libido, mood, motivation and so on.
But what’s the scientifical explanation of it? We have god damn space shuttles and we can’t answer to this question?
@trevor_5 There is none except the simple and logical fact everyone is unique. There are theories though. Too many things in medicine dont have enough scientific data. We are still too primitive in understanding our bodies and do what we can with the knowledge we have
Some doctors think the endocrine disrupts plug the test receptors in different people to different extend. But before you ask there is not yet enough research to backup this
Just accept we dont know all answers
Everyone is unique? You mean he can’t just plug the values into a calculator?
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You still dont get the point from my log right. I know MY values and how much I need to feel good. So yes, I can plug my values into calculator and Im doing exactly that for my case. Try to think more deeply about this stuff
Think more deeply? Hilarious! Like I said… you are always good for a laugh. 
Yep you dont seem to put much mental effort in understanding what is written or maybe I need to use more simple words when explaining to you?
Yup, that’s the problem. I don’t understand. Let me get out my calculator so I can figure it out.
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Next time I can use one word sentences to be easier
Please dumb it down for me. Maybe you can start by explaining how 'estro’gen is an 'andro’gen?
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The truth is, we simply do not have a great understanding of the human brain. Part of the difficulty is in measuring and getting tissue samples in controlled experiments. So the science of understanding the brain lags behind the rest of the body.
However, I see two reasons why some feel different with the same level of Free T entering the brain:
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The first explanation is the one vonko is pointing to is that we are all different and need different levels of Free T in the brain to feel right. Some ideas might be differences in either the number or activity of T receptors. Another might be different levels of 5α-reductase enzyme in libido centers of the brain. Another I recently read in a different post is the level of aromatase enzyme in libido centers, pointing to the importance of estradiol in libido. There are no doubt other ‘scientific’ explanations.
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Another is that some guys might simply not remember what it’s like to have a strong(er) libido and claim to feel normal, but in actuality could feel better with TRT. The frog in the pot of boiling water analogy comes to mind. Throw a frog into a pot of boiling water and it feels the heat right away. However, pot the frog in a pot of cold water and slowly bring it to a boil, and the frog adjusts to the temperature until it’s too late.
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It would be reasonable to consider that testosterone has nothing to do with the problem in many of them, but it cranking up the androgen levels makes them feel better in spite of the undiagnosed issue.
This theory has way less evidence backup than the androgen resistance theory
Interesting world you live in. Let me know if you decide to join the real one.
So Hardartery…
Are you saying that guys with highs shbg and low free T but with normal total t levels actually feel shitty not because of their low free t levels but some other reason?
Does everyone need the same amount of calories to maintain equilibrium?
Does everyone need the same amount of alcohol to get drunk?
Can everyone tolerate the same amount of chilli in a curry?
Can everyone tolerate the same amount of pollen?
Does everyone shake after 2 strong coffees?
I could go on…
I’m saying, there should not be a rush to jump to TRT. It may be that no other cause can or will be found, so you are left with treating the symptoms, but if high SHBG is the indicator and the other androgen numbers are normal, or high normal, then you should wonder why. We are lacking in explanations for it, but that doesn’t meant that there isn’t a serious underlying issue not being addressed. Fact is, it may not be currently possible to diagnose the problem, in which case a large TRT dose may be the only relief - but it’s always better to fix the actual underlying issue when possible than to treat symptoms. Systemlord was tooth and nail TRT, when his problems were not that at all and quite serious. He had different symptoms and a low SHBG, but I think everyone is a little quick to get on the bandwagon without doing their due diligence first.
So you are trying to push theory without any backup as truth and call me wrong? What pills are you taking? @dbossa what do you think about your buddy’s theory?
How retarded are you, exactly? Are you expecting a study showing SHBG as a correlation to something? Or a demonstration of causation? Advocating a thorough investigation of the cause for elevated SHBG before deciding on a treatment is hardly forwarding a controversial theory lacking support. It is certainly better than your approach, which seems to be simply applying a different colour band-aid to your wound every few weeks.
I realize that you are simply looking for myposts and trying to take pot shots. You should realize that you aren’t very good at it and are simply demonstrating repeatedly how stupid you are.